Central noradrenergic system modulates plasma interleukin-6 production by peripheral interleukin-1

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 273, Issue 2 42-2, 1997, Pages

  Huang, Qin Heng ^a   Takaki, Atsushi ^a   Arimura, Akira ^a  

^a TULANE UNIVERSITY   (United States)

Author keywords

6 hydroxydopamine; Adrenalectomy; Adrenergic receptor antagonists; Autonomic nervous system; Central noradrenergic system; Interleukin 1; Spleen lymphocytes

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 6;

ADRENALECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; IMMUNOREGULATION; MALE; NONHUMAN; NORADRENALIN BRAIN LEVEL; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; SYMPATHETIC INNERVATION;

EID: 0030809678     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.273.2.r731     Document Type: Article

References (16)

1. Akira, S., T. Hirano, T. Taga, and T. Kishimoto. Biology of multifunctional cytokines: IL-6 and related molecule (IL-1 and TNF). FASEB J. 4: 2860-2867, 1990.
2. Akiyoshi, M., Y. Shimizu, and M. Saito. Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats. Biochem. Biophys. Res. Commun. 173: 1266-1270, 1990.
3. Banks, W. A., A. J. Kastin, and D. A. Durham. Bidirectional transport of interleukin-1a across the blood-brain barrier. Brain Res. Bull. 23: 433-437, 1989.
4. Chuluyan, H. E., D. Saphier, W. M. Rohn, and A. J. Dunn. Noradrenergic innervation of the hypothalamus participates in adrenocortical responses to interleukin-1. Neuroendocrinology 56: 106-111, 1992.
5. De Simoni, M. G., A. De Luigi, L. Gemma, M. Sironi, A. Manfridi, and P. Ghezzi. Modulation of systemic interleukin-6 induction by central interleukin-1. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R739-R742, 1993.
6. De Simoni, M. G., M. Sironi, A. De Luigi, A. Manfridi, A. Mantovani, and P. Ghezzi. Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6. J. Exp. Med. 171: 1773-1778, 1990.
7. Dunn, A. J. Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone. Life Sci. 43: 429-435, 1988.
8. Eliesson, A., K. J. Kovács, and P. E. Sawchenko. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 14: 897-913, 1994.
9. Felten, D. L. Direct innervation of lymphoid organs: substrate for neurotransmitter signaling of cells of the immune system. Neuropsychobiology 28: 110-112, 1993.
10. Felten, D. L., S. Y. Felten, D. L. Bellinger, S. L. Carlson, K. D. Ackerman, K. S. Madden, J. A. Olschowki, and S. Livnat. Noradrenergic sympathetic neural interactions with the immune system: structure and function. Immunol. Rev. 100: 225-260, 1987.
11. Felten, S. Y., J. Housel, and D. L. Felten. Use of in vivo dialysis for evaluation of splenic norepinephrine and serotonin (Abstract). Soc. Neurosci. Abstr. 12: 1065, 1986.
12. Fisher, L. A. Central actions of corticotropin-releasing factor on autonomic nervous activity and cardiovascular functioning. Ciba Found. Symp. 172: 243-253, 1993.
13. 3H]dopa in various regions of the brain. J. Neurochem. 13: 655-669, 1966.
14. Gool, J. V., H. V. Vugt, M. Helle, and L. A. Aarden. The relation among stress, adrenaline, interleukin-6 and acute phase protein synthesis in the rat. Clin. Immunol. Immunopathol. 57: 200-210, 1990.
15. Hack, C. E., E. R. De Groot, R. J. Felt-Bersma, J. H. Nuijens, R. J. Strack van Schijndel, A. J. Eerenberg-Belmer, L. G. Thijs, and L. A. Aarden. Increased plasma levels of interleukin-6 in sepsis. Blood 74: 1704-1710, 1989.
16. Johnston, E. O., T. C. Kamilaris, G. P. Chrousos, and P. W. Gold. Mechanisms of stress: a dynamic overview of hormonal and behavioral homeostasis. Neurosci. Biobehav. Rev. 16: 115-130, 1992.