Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 5, 1998, Pages 1573-1579

  Späth Schwalbe, Ernst ^a,f   Hansen, Kirsten ^b   Schmidt, Frauke ^b   Schrezenmeier, Hubert ^c   Marshall, Lisa ^b   Burger, Klaus ^d   Fehm, Horst L ^b   Born, Jan ^b,e  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d Sandoz Pharma Ltd   (Germany)

^e UNIVERSITY OF BAMBERG   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CORTICOTROPIN; CYTOKINE; GAMMA INTERFERON; GROWTH HORMONE; HYDROCORTISONE; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; THYROTROPIN;

ACUTE PHASE RESPONSE; ADULT; ARTICLE; BODY TEMPERATURE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFECT; ENDOCRINE FUNCTION; GROWTH HORMONE RELEASE; HEART RATE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS ADRENAL SYSTEM; MALE; MOOD; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REM SLEEP; SLEEP; SLEEP TIME; SLOW WAVE SLEEP; SUBCUTANEOUS DRUG ADMINISTRATION; THYROTROPIN RELEASE;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ADULT; AFFECT; C-REACTIVE PROTEIN; CENTRAL NERVOUS SYSTEM; CIRCADIAN RHYTHM; DOUBLE-BLIND METHOD; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; MALE; PITUITARY GLAND; RECOMBINANT PROTEINS; SLEEP; THYROTROPIN;

EID: 0031724942     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.5.1573     Document Type: Article

References (47)

1. Kishimoto T. 1489 The biology of interleukin-6, Blood. 74:1-10.
2. Hirano T, Akira S, Taga T, Kishimoto T. 1990 Biological and clinical aspects of interleukin 6. Immunol Today. 11:443-449.
3. Van Snick J. 1990 Interleukin-6: an overview. Annu Rev Immunol. 8:253-278.
4. Akira S, Hirano T, Taga T, Kishimoto T. 1990 Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J. 4:2860-2867.
5. Krueger JM, Obal F, Opp M, Toth L, Johannsen L, Cady AB. 1990 Somnogenic cytokines and models concerning their effects on sleep. Yale J Biol Med. 63:157-172.
6. Krueger JM, Majde JA. 1995 Cytokines and sleep. Int Arch Allergy Immunol. 106:97-100.
7. Baumann H, Gauldie J. 1994 The acute phase response. Immunol Today. 15:74-80.
8. Weber J, Yang JC, Topalian SL, et al. 1993 Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies. J Clin Oncol. 11:499-506.
9. Van Gameren MM, Willemse PHB, Mulder NH, et al. 1994 Effects of recombinant human interleukin-6 in cancer patients: a phase I-II study. Blood. 84:1434-1441.
10. Schrezenmeier H, Späth-Schwalbe E, Drechsler S, et al. 1993 Phase I trials of interleukin-6 in patients with advanced renal cell carcinoma and patients with aplastic anemia: effects of longterm application and differences of hemopoietic responses to IL-6 in patients with normal hemopoiesis vs. patients with aplastic anemia. Blood. 82:368a (Abstract).
11. Gordon MS, Nemunaitis J, Hoffman R, et al. 1995 A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia, Blood. 85:3066-3076.
12. Heney D, Lewis IJ, Evans SW, Banks R, Bailey CC, Whicher JT. 1992 Interleukin-6 and its relationship to C-reactive protein and fever in children with febrile neutropenia. J Infect Dis. 165:886-902.
13. Engel A, Kern WV, Mürdter G, Kern P. 1994 Kinetics and correlation with body temperature of circulating interleukin-6, interleukin-8, tumor necrosis factor alpha and interleukin-1 beta in patients with fever and neutropenia. Infection. 22:160-168.
14. Janke W, Debus G. 1978 Die Eigenschaftswörterliste EWL. Eine mehrdimensionale Methode zur Beschreibung von Aspekten des Befindens. Verlag für Psychologie, Hogrefe, Göttingen, Germany.
15. Rechtschaffen A, Kales A. 1968 A manual of standardized terminology, techniques and scoring system for sleep of human subjects. Washington DC: US Government Printing Office, NIH publication 204.
16. Dixon WJ. 1990 BMDP statistical software. Los Angeles: University of California Press.
17. Greenhouse SW, Geisser S. 1959 On methods in the analysis of profile data. Psychometrica. 24:95-112.
18. Späth-Schwalbe E, Born J, Schrezenmeier H, et al. 1994 Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man. J Clin Endocrinol Metab. 79:1212-1214.
19. Mastorakos G, Chrousos GP, Weber JS. 1993 Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. J Clin Endocrinol Metab. 77:1690-1694.
20. Naito Y, Fukata J, Tamai S, et al. 1991 Biphasic changes in the hypothalamic-pituitary-adrenal function during early recovery period after major abdominal surgery. J Clin Endocrinol Metab. 73:111-117.
21. Naito Y, Tamai S, Shingu K, et al. 1992 Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology. 77:426-431.
22. Salas MA, Evans SW, Levell MJ, Whicher JT. 1990 Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin Exp Immunol. 79:470-473.
23. Päth G, Bomstein SR, Späth-Schwalbe E, Scherbaum WA. 1996 Direct effects of interleukin-6 on human adrenal cells. Endocr Res. 22:867-873.
24. Weber MM, Michl P, Auernhammer CJ, Engelhardt D. 1997 Interleukin-3 and interleukin-6 stimulate cortisol secretion from adult human adrenocortical cells. Endocrinology. 138:2207-2210.
25. Allan JS, Czeisler CA. 1994 Persistence of the circadian thyrotropin rhythm under constant conditions and after light-induced shifts of circadian phase. J Clin Endocrinol Metab. 79:508-512.
26. Stouthard JML, Van der Poll T, Endert E, et al. 1994 Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans. J Clin Endocrinol Metab. 79:1342-1346.
27. Späth-Schwalbe E, Schrezenmeier H, Bornstein SR, Burger K, Porzsolt F, Born J. 1996 Endocrine effects of recombinant interleukin-6 in man. Neuroendocrinology. 63:237-243.
28. Kakucska I, Romero LI, Clark BD, et al. 1994 Suppression of thyrotropinreleasing hormone gene expression by interleukin-1-beta in the rat: implications for nonthyroidal illness. Neuroendocrinology. 59:129-137.
29. Kakucska I, Qi Y, Lechan RM. 1995 Changes in adrenal status affect hypothalamic thyrotropin-releasing hormone gene expression in parallel with corticotropin-releasing hormone. Endocrinology. 136:2795-2802.
30. Van Haasteren GAC, Van der Meer MJM, Hermus ARMM, et al. 1994 Different effects of continuous infusion of interleukin-1 and interleukin-6 on the hypothalamic-hypophysial-thyroid axis. Endocrinology. 135:1336-1345.
31. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM. 1993 Association between serum interleukin-6 and serum 3,5,3′-triiodothyronine in nonthyroidal illness. J Clin Endocrinol Metab. 77:1695-1699.
32. Romijn JA, Wiersinga WM. 1990 Decreased nocturnal surge of thyrotropin in nonthyroidal illness. J Clin Endocrinol Metab. 70:35-40.
33. Reincke M, Heppner C, Petzke F, et al. 1994 Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin-6 concentrations in african trypanosomiasis. Neuro Immuno Modulation. 1:14-22.
34. Vgontzas AN, Papanicolau DA, Bixler EO, Kales A, Tyson K, Chrousos GP. 1997 Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab. 82:1313-1316.
35. Opp M, Obal F, Cady AB, Johannsen L, Krueger JM. 1989 Interleukin-6 is pyrogenic but not somnogenic. Physiol Behav. 45:1069-1072.
36. Born J, Späth-Schwalbe E, Schwakenhofer H, Kern W, Fehm HL. 1989 Influences of corticotropin-releasing hormone, adrenocorticotropin, and cortisol on sleep in normal man. J Clin Endocrinol Metab. 68:904-911.
37. Pollmaecher T, Schreiber W, Gudewill S, et al. 1993 Influence of endotoxin on nocturnal sleep in humans. Am J Physiol. 264:R1077-R1083.
38. Nakazawa Y, Kotorii T, Horikawa S, Kororii M, Ohshima M, Hasuzawa H. 1979 Individual variations in the effects of flurazepam, corazepam, L-dopa and thyrotropin-releasing hormone on REM sleep in man. Psychopharmacology. 60:203-206.
39. Kales A, Heuser G, Jacobson A, et al. 1967 All night sleep studies in hypothyroid patients before treatment. J Clin Endocrinol Metab. 27:1593-1599.
40. Home JA, Reid AJ. 1985 Night-time sleep EEG changes following body heating in a warm bath. Electroencephalogr Clin Neurophysiol. 60:154-157.
41. Horne JA, Moore VJ. 1985 Sleep effects of exercise with and without additional body cooling. Electroencephalogr Clin Neurophysiol. 60:33-38.
42. Cajochen C, Dijk DJ, Borbély AA. 1992 Dynamics of EEG slow wave activity and core body temperature in human sleep after exposure to bright light. Sleep. 15:337-343.
43. Watkins LR, Maier SF, Goehler LE. 1995 Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Sci. 57:1011-1026.
44. Bluthé RM, Pawlowski M, Suarez S, et al. 1994 Synergy between tumor necrosis factor-α and interleukin-1 in the induction of sickness behaviour in mice. Psychoneuroendocrinology. 19:197-207.
45. Dantzer R, Bluthé RM, Kent S, Goodall G. 1993 Behavioral effects of cytokines: an insight into mechanisms of sickness behaviour. In: De Souza EB, ed. Neurobiology of cytokines. Part B. San Diego: Academic Press; 130-150.
46. Plihal W, Krug R, Pietrowsky R, Fehm HL, Born J. 1996 Corticosteroid receptor mediated effects on mood in humans. Psychoneuroendocrinology. 21:515-522.
47. Born J, Bathelt B, Pietrowsky R, Pauschinger P, Fehm HL. 1990 Influences of peripheral adrenocorticotropin 1-39 (ACTH) and human corticotropin releasing hormone (h-CRH) on human auditory evoked potentials (AEP). Psychopharmacology. 101:34-38.