IRAK and TAK1 are required for IL-18-mediated signaling

European Journal of Immunology

Volumn 31, Issue 12, 2001, Pages 3747-3754

  Wald, David ^a   Commane, Mairead ^a   Stark, George R ^a   Li, Xiaoxia ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cytokine; Signal transduction; Transcription factor

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 18; INTERLEUKIN 2; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL ACTIVATION; CELL MUTANT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEATH; EMBRYO; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; NATURAL KILLER CELL; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION; TH1 CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARRIER PROTEINS; CELLS, CULTURED; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-18; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 0035667195     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200112)31:12<3747::AID-IMMU3747>3.0.CO;2-E     Document Type: Article

References (49)

1. IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
2. A proinflammatory role for IL-18 rheumatoid arthritis
3. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
4. Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice
5. Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
6. Defective NK cell activity and Th1 response in IL-18-deficient mice
7. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
8. Synergistic proliferation and activation of natural killer cells by interleukin 12 and interleukin 18
9. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice
10. Cloning of a new cytokine that induces IFN-gamma production by T cells
11. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
12. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
13. Cutting edge: Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
14. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
15. Effects of IL-1 receptor accessory protein on IL-1 binding
16. Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response
17. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
18. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
19. MyD88, an adapter protein involved in interleukin-1 signaling
20. IRAK: A kinase associated with the interleukin-1 receptor
21. TRAF6 is a signal transducer for interleukin-1
22. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
23. IRAK leads to activation of TAK1 MAPKKK by inducing TAB2 translocation in the IL-1 signaling pathway
24. The kinase TAK1 can activate the NIK-1 kappaB as well as the MAP kinase cascade in the IL-1 signaling pathway
25. The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
26. Identification and characterization of an IkappaB kinase
27. IKK-1 and IKK-2: Cytokine-activated IkappaB kinases essential for NF-kappaB activation
28. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/ReIA subunit
29. Phosphatidylinositol 3-kinase in interleukin-1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation
30. Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of ReIA/p65 on serine 529
31. Transcription factor ATF2 regulation by the JNK signal transduction pathway
32. Targeted disruption of the MyD88 gene results in loss of IL-1- And IL-18-mediated function
33. Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
34. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
35. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells
36. Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1
37. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
38. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
39. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
40. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
41. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells
42. Interleukin-1/Toll receptor family members: Receptor structure and signal transduction pathways
43. The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for pro-inflammatory interleukins and microbial products
44. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
45. Unresponsiveness of MyD88-deficient mice to endotoxin
46. IL-1-induced NFkappaB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)
47. Three NF-kappaB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression
48. Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines
49. Interferon-α-regulated nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator