Modulation of PECAM-1 (CD31) expression in human endothelial cells: Effect of IFNγ and IL-10

Journal of Vascular Research

Volumn 36, Issue 2, 1999, Pages 106-113

  Buján, Julia ^a   Gimeno, Maria José ^a   Prieto, Alfredo ^a   Pascual, Gemma ^a   Bellón, Juan Manuel ^a   Alvarez Mon, Melchor ^a,b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

Author keywords

Endothelial cells; IFN ; IL 10; PECAM 1

Indexed keywords

CD31 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10;

ANTIGEN EXPRESSION; ARTICLE; CELL INTERACTION; CELL STRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION;

ANTIGENS, CD31; BLOTTING, WESTERN; CELL DIVISION; ENDOTHELIUM, VASCULAR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-10; MICROSCOPY, ELECTRON, SCANNING; STAINING AND LABELING; UMBILICAL VEINS;

EID: 0032946918     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000025632     Document Type: Article

References (25)

1. Springer TA: Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 1995;57:827-872.
2. Mantovani A, Bussolino F, Dejana E: Cytokine regulation of endothelial cell function. FASEB J 1992;6:2591-2599.
3. Pober JS, Cotran RS: Cytokines and endothelial cell biology. Physiol Rev 1990;70:427-451.
4. De Beaux AC, Maingay JP, Ross JA, Fearon KC, Carter DC: Interleukin-4 and interleukin-10 increase endotoxin-stimulated human umbilical vein endothelial cell interleukin-8 release. J Interferon Cytokine Res 1995;15:441-445.
5. Davies MG, Hagen PO: The vascular endothelium: A new horizon. Ann Surg 1993;218:593-609.
6. Pober JS, Gimbrone MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA: Overlapping patterns of activation of human endothelial cells by interleukin1, tumor necrosis factor and immune interferon. J Immunol 1986;137:1893-1896.
7. Furie MB, McHugh DD: Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor-alpha. J Immunol 1989;143:3309-3317.
8. Billiau A, Diskmans R: Interferon gamma: Mechanism of action and therapeutic potential. Biochem Pharmacol 1990;40:1433-1439.
9. Stewart RJ, Kashxur TS; Marsden PA: Vascular endothelial platelet endothelial adhesion molecule-1 (PECAM-1) expression is decreased by TNF-alpha and IFN-gamma. Evidence for cytokine-induced destabilization of messenger ribonucleic acid transcripts in bovine endothelial cells. J Immunol 1996;156: 1221-1228.
10. Defilippi P, Truffa G, Stefanuto G, Altruda F, Silengo L, Garone G: Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor (integrin beta 3) in human endothelial cells. J Biol Chem 1991;266:7638-7645.
11. De Waal-Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE: Interleukin 10 (IL10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL10 produced by monocytes. J Exp Med 1991;174:1209-1220.
12. Muller WA, Berman ME, Newman PJ, Delisse HM, Albelda SM: A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31). J Exp Med 1992;175: 1401-1404.
13. Delisser HM, Chilkotowsky J, Yan HC, Daise ML, Buch CA, Albelda SM: Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD 31) result in changes in ligand binding properties, J Cell Biol 1994;124:195-203.
14. Fawcett J, Buckley C, Holness CL, Bird IN, Spragg JH, Saunders J, Harris A, Simmons DL: Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts. J Cell Biol 1995;128:1229-1241.
15. Piali L, Hammel P, Uherek C, Bachmann F, Gisler RH, Dunon D, Imhof BA: CD31/PECAM-1 is ligand for avb3 integrin involved in adhesion of leukocytes to endothelium. J Cell Biol 1995;130:451-460.
16. Rival Y, Del Maschio A, Rabiet MJ, Dejana E, Duperray A: Inhibition of platelet endothelial cell adhesion molecule-1 synthesis and leukocyte transmigration in endothelial cells by the combined action of TNF alpha and IFN gamma. J Immunol 1996;157:1233-1241.
17. Jaffe EA, Nachman RL, Becker CG, Minick CR: Culture of human endothelial cells derived from umbilical cord veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973;52:2745-2756.
18. Garcia-Honduvilla N, Buján J, Lizarbe MA, Bellón JM, Olmo N, Hernando A: Adhesion and stability of fibronectin on PTFE before and after seeding with normal and synchronized endothelial cells: In vitro study. Artif Organs 1994;19:144-153.
19. Prieto A, Reyes E, Garcia-Suárez J, Carrión F, Hernández-Fuentes MP, Cháfer J, Alvarez-Mon M: A low blood lymphocyte count is associated with an expansion of activated cytotoxic lymphocytes in patients with B-cell chronic lymphocyte leukaemia. Eur J Haematol 1997; 58:89-100.
20. Ferrero E, Ferrero ME, Ruggero P, Zocchi MR: The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function. FEBS Lett 1995;373:323-326.
21. DeLisser HM, Christofidou-Solomidou M, Strieter RM, Burdick MD, Robinson CS, Wexler RS, Kerr JS, Garlanda C, Merwin JR, Madri JA, Albelda SM: Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol 1997;15:671-677.
22. Goldberger A, Middleton KA, Oliver JA, Paddock C, Yan HC, DeLisser HM, Albelda SM, Newman PJ: Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form. J Biol Chem 1994;269:17183-17191.
23. Romer LH, McLean NV, Yan HC, Daise M, Sun J, DeLisser HM: IFN gamma and TNF alpha induce redistribution of PECAM-1 (CD31) on human endothelial cells. J Immunol 1995;154:6582-6592.
24. De Waal-Malefyt R, Figdor CG, Huijbens R, Mohan-Peterson S, Bennett B, Culpepper J, Dang W, Zurawski G. De Vries JE: Effects of IL13 on phenotype, cytokine production, and cytotoxic function of human monocytes. J Immunol 1993;151:6370-6381.
25. Buján J, Bellón JM, Gimeno MJ, Garcia-Honduvilla N, Pareja JA, Alvarez-Mon M: High concentrations of interleukin 10 cause damage to vascular endothelium. Angiología 1996;6: 257-264.