Expression of transporter associated with antigen processing-1 in the endocrine cells of human pancreatic islets: Effect of cytokines and evidence of hyperexpression in IDDM

Diabetes

Volumn 45, Issue 6, 1996, Pages 779-788

  Vives Pi, Marta ^a   Armengol, Maria Pilar ^a   Alcalde, Laura ^a   Costa, Manuela ^a   Somoza, Nuria ^a   Vargas, Francesca ^a   Jaraquemada, Dolores ^a   Pujol Borrell, Ricardo ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; MEMBRANE PROTEIN; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; INSULIN DEPENDENT DIABETES MELLITUS; NORTHERN BLOTTING; PANCREAS ISLET CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPPRESSOR CELL;

EID: 0029887188     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.6.779     Document Type: Article

References (44)

1. Bottazzo GF, Foulis AK, Bosi E, Todd I, Pujol-Borrell R: Pancreatic β-cell damage: in search of novel pathogenetic factors. Diabetes Care 11 (Suppl. 1):24-28, 1988
2. Miyazaki A, Nonaka K, Tarui S: Lymphocyte subsets in islets and spleen of the NOD mouse. In Insulitis and Type I Diabetes. Tarui SI, Tochino I, Nonaka K, Eds. Tokyo, Academic, 1986, p. 83-90
3. Bottazzo GF, Dean BM, McNally GM, McKay EH, Swift PGF, Gamble DR: In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313:353-360, 1985
4. Hanninen A, Jalkanen S, Salmi M, Toikkanen M, Nikolakaros G, Simell O: Macrophages, T cell receptor usage and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 90:1901-1910, 1992
5. Somoza N, Vargas F, Roura-Mir C, Vives-Pi M, Fernández-Figueras M, Ariza A, Gomis R, Bragado R, Martí M, Jaraquemada D, Pujol-Borrell R: Pancreas in recent onset insulin-dependent diabetes mellitus. J Immunol 153:1360-1377, 1994
6. Neefjes JJ, Schumacher TNM, Ploegh HL: Assembly and intracellular transport of major histocompatibility complex molecules. Curr Opin Cell Biol 3:601-609, 1991
7. Goldberg AL, Rock KL: Proteolysis, proteasomes and antigen presentation. Nature 357:375-379, 1992
8. Kleumeer MJ, Kelly A, Geuze HJ, Slot JW, Townsend A, Trowsdale J: Location of MHC-encoded transporters in the endoplasmic reticulum and cis-golgi. Nature 357:342-344, 1992
9. Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Plous D, DeMars R: A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. Nature 348:744-747, 1990
10. Shepherd JC, Schumacher TNM, Ashton-Rickardt PG, Imaeda S, Ploegh HL, Janeway CA, Tonegawa S: TAP-1 dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 74:577-684, 1993
11. Spies T, DeMars R: Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature 351:323-324, 1991
12. Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S: TAP-1 mutant mice deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell 71:1205-1214, 1992
13. Todd JA, Bell JI, McDevitt HO: HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329:599-604, 1987
14. Davies JL, Kawaguchi Y, Bennet ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA: A genome wide search for human type 1 diabetes susceptibility genes. Nature 371:130-136, 1994
15. Trowsdale J, Hanson I, Mockridge I, Beck S, Towsend A, Kelly A: Sequences encoded in the class II region of the MHC related to the ABC superfamily of transporters. Nature 348:741-743, 1990
16. Faustman D, Li X, Lin HY, Fu Y, Eisenbarth G, Avruch J, Guo J: Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science 254:1756-1761, 1991
17. Li F, Guo J, Fu Y, Yan G, Faustman D: Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse. Proc Natl Acad Sci USA 91:11128-11132, 1994
18. Gaskins HR, Monaco JJ, Leiter EH: Expression of intra-MHC transporter (Ham) genes and Class I antigens in diabetes-susceptible NOD mice. Science 256:1826-1828, 1992
19. Jackson DG, Capra JD: TAP1 alleles in insulin dependent diabetes-mellitus: a newly defined centromeric boundary of disease susceptibility. Proc Natl Acad Sci USA 90:11079-11083, 1993
20. Ronningen KS, Undlien DE, Ploski R, Maouni N, Konrad RJ, Jensen E, Hornes E, Reijonen H, Colonna M, Monos DS, Strominger JL, Thorsby E: Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus. Eur J Immunol 23:1050-1056, 1993
21. Van Endert PM, Liblau RS, Patel SD, Fugger L, Lopez T, Pociot F, Nerup J: Major histocompatibility complex-encoded antigen processing gene polymorphism. Diabetes 43:110-117, 1994
22. Ploski R, Undlien DE, Vinje O, Forre O, Thorsby E, Ronningen KS: Polymorphism of human major histocompatibility complex-encoded transporter associated with antigen processing (TAP) genes and susceptibility to juvenile rheumatoid arthritis. Hum Immunol 39:54-60, 1994
23. Middleton D, Megaw G, Cullen C, Hawkins S, Darke C, Savage DA: TAP1 and TAP2 polymorphism in multiple sclerosis patients. Hum Immunol 40:131-134, 1994
24. Djilali-Saiah I, Caillat-Zucman S, Schmitz J, Chaves-Vieira MJ, Bach JF: Polymorphism of antigen processing (TAP, LMP) and HLA class II genes in celiac disease. Hum Immunol 40:8-16, 1994
25. Huang X, Yuan J, Goddardd A, Foulis A, James RFA, Lernmark A, Pujol-Borrell R, Rabinovitch A, Somoza N, Stewart TA: Interferon expression in the pancreata of patients with type I diabetes. Diabetes 44:658-604, 1995
26. Bottazzo GF, Florin-Christensen A, Doniach D: Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet ii:1279-1283, 1974
27. Vives M, Sarri Y, Conget I, Somoza N, Alcalde L, Armengol P, Fernández J, Lorenzo C, Martí M, Soldevila G, Usac EF, Mañalich M, Gomis R, Pujol-Borrell R: Human islet function after automated isolation and bovine serum albumin gradient purification. Transplantation 53:243-245, 1992
28. Lake SP, Basset PD, Larkins A, Revell J, Walczak K, Chamberlain J, Rumford GM, London NJM, Veicht PS, Bell PRF, James RFL: Large scale purification of human islets utilizing discontinuous albumin gradient on IBM 2991 cell separator. Diabetes 38:143-145, 1989
29. 28a. Vargas F, Vives-Pi M, Somoza N, Alcalde L, Armengol P, Martí M, Serradell L, Costa M, Fernández-Llamazares J, Sanmartí A, Pujol-Borrell R: Advantages in using the COBE cell separator and metrizamide gradients for human islet purification. Transplantation. In press
30. Latif ZA, Noel J, Alejandro R: A simple method for staining fresh and cultured islets. Transplantation 45:827-829, 1988
31. Soldevila G, Buscema M, Marini V, Sutton R, James R, Bloom SR, Robertson RP, Mirakian R, Pujol-Borrell R, Bottazzo GF: Transfection with SV40 gene of human pancreatic endocrine cells. J Autoimmunity 4:381-396, 1991
32. Vives M, Soldevila G, Alcalde L, Lorenzo C, Somoza N, Pujol-Borrell R: Adhesion molecules in human islet beta cells: de novo induction of ICAM-1 but not LFA-3. Diabetes 40:1382-1390, 1992
33. Spies T, Cerundolo V, Colonna M, Cresswell P, Towsend A, DeMars R: Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer. Nature 355:644-646, 1992
34. Vives-Pi M, Somoza N, Vargas F, Armengol P, Sarri Y, Wu JY, Pujol-Borrell R: Expression of glutamic acid decarboxylase (GAD) in the alpha, beta and delta cells of normal and diabetic pancreases: implications for the pathogenesis of type I diabetes. Clin Exp Immunol 92:391-396, 1992
35. Vives M, Somoza N, Soldevila G, Gomis R, Lucas A, Sanmartí A, Pujol-Borrell R: Reevaluation of autoantibodies to islet cell membrane in IDDM. Diabetes 41:1624-1631, 1992
36. Chomczinsky P, Sacchi N: Single step of RNA isolation by guanidinium thiocianate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
37. Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann M: Hypothesis: role of aberrant HLA-DR expression and antigen presentation in the induction of endocrine autoimmunity. Lancet ii:1115-1119, 1983
38. Epperson DE, Arnold D, Spies T, Cresswell P, Pober JS, Johnson DR: Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. J Immunol 149:3297-3301, 1992
39. Foulis AK, Farquharson MA: Aberrant expression of HLA DR antigens in insulin-containing beta cells in recent-onset type 1 diabetes mellitus. Diabetes 35:1215-1224, 1986
40. Akiyama K, Yokota K, Kagawa S, Shimbara N, Tamura T, Akioka H, Nothwang HG, Noda C, Tanaka K, Ichihara A: cDNA cloning and interferon-gamma down-regulation of proteosomal subunits X and Y. Science 265:1231-1234, 1994
41. Suh WK, Cohen-Doyle MF, Früh K, Wang K, Peterson PA, Williams DB: Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264:1322-1326, 1994
42. Foulis AK, Farquharson MA, Meager A: Immunoreactive alpha-interferon in insulin-secreting beta cells in type I diabetes mellitus. Lancet ii:1423-1427, 1986
43. Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM, Tonegawa S: Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651-663, 1994
44. Dyalll R, Vasovic LV, Molano A, Nikolic-Zugic J: CD4-independent in vivo priming of murine CTL by optimal MHC class I-restricted peptides derived from intracellular pathogens. Int Immunol 7:1205-1212, 1995