Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity

Journal of Experimental Medicine

Volumn 185, Issue 7, 1997, Pages 1203-1210

  Yamamoto, Shingo ^a,b   Takeda, Yoshifumi ^b,c   Yamamoto, Masafumi ^a   Kurazono, Hisao ^a   Imaoka, Koichi ^a   Yamamoto, Miho ^a   Fujihashi, Kohtaro ^a   Noda, Masatoshi ^d   Kiyono, Hiroshi ^a,e   McGhee, Jerry R ^a  

^a University of Alabama at Birmingham   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^d CHIBA UNIVERSITY   (Japan)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHO CELL; CHOLERA; CONTROLLED STUDY; DIARRHEA; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; TOXICITY TESTING; TOXIN ANALYSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CHO CELLS; CHOLERA TOXIN; CRICETINAE; CYCLIC AMP; CYTOKINES; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; ILEUM; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MUCOUS MEMBRANE; MUTATION; POLY(ADP-RIBOSE) POLYMERASES; TH2 CELLS; TOXICITY TESTS;

EID: 0030902280     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.7.1203     Document Type: Article

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