메뉴 건너뛰기




Volumn 1, Issue 4, 2001, Pages 342-352

Scoring a bull's-eye against cancer genome targets

Author keywords

Deacetylation targets; Genetics; Histone acetylation; Human and cancer genome sequences; Kinase targets; Mechanism based drugs; Molecular Medicine; New molecular targets; Pharmacology

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; HISTONE DEACETYLASE; PHOSPHOTRANSFERASE;

EID: 0035431318     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(01)00060-1     Document Type: Review
Times cited : (37)

References (74)
  • 1
    • 77953616231 scopus 로고    scopus 로고
    • V.T. De Vita, S. Hellman, & S.A. Rosenberg. Philadelphia: Lippincott. The latest ediition of the standard oncology reference book (the oncology bible!).
    • De Vita V.T., Hellman S., Rosenberg S.A. Cancer: Principles and Practice of Oncology. edn 6 :2001;Lippincott, Philadelphia. The latest ediition of the standard oncology reference book (the oncology bible!).
    • (2001) Cancer: Principles and Practice of Oncology Edn 6
  • 2
    • 0032931825 scopus 로고    scopus 로고
    • Essential drugs for cancer therapy: A World Health Organisation consultation
    • A critical survey of the utility of cancer drugs.
    • Sikora K., Advani S., Koroltchouk V., Magrath I., Levy L., Pinedo H., Schwartsmann G., Tattesall M., Yan S. Essential drugs for cancer therapy: a World Health Organisation consultation. Ann Oncol. 10:1999;385-390. A critical survey of the utility of cancer drugs.
    • (1999) Ann Oncol , vol.10 , pp. 385-390
    • Sikora, K.1    Advani, S.2    Koroltchouk, V.3    Magrath, I.4    Levy, L.5    Pinedo, H.6    Schwartsmann, G.7    Tattesall, M.8    Yan, S.9
  • 3
    • 0033402254 scopus 로고    scopus 로고
    • Millennium review. Discovering novel chemotherapeutic drugs for the third millennium
    • A lengthy review of the development of anticancer agents acting on new molecular targets.
    • Garret M.D., Workman P. Millennium review. Discovering novel chemotherapeutic drugs for the third millennium. Eur J Cancer. 35:1999;2010-2030. A lengthy review of the development of anticancer agents acting on new molecular targets.
    • (1999) Eur J Cancer , vol.35 , pp. 2010-2030
    • Garret, M.D.1    Workman, P.2
  • 4
    • 0034087224 scopus 로고    scopus 로고
    • Towards genomic cancer pharmacology: Innovative drugs for the new millennium
    • A concise editorial on post-genomic cancer drug development, focusing on the improved understanding of the molecular causation of various cancers and the implementation of high-throughput technologies to increase the speed and efficiency and drug development.
    • Workman P. Towards genomic cancer pharmacology: innovative drugs for the new millennium. Curr Opin Oncol Endocrine Metab Invest Drugs. 2:2000;21-25. A concise editorial on post-genomic cancer drug development, focusing on the improved understanding of the molecular causation of various cancers and the implementation of high-throughput technologies to increase the speed and efficiency and drug development.
    • (2000) Curr Opin Oncol Endocrine Metab Invest Drugs , vol.2 , pp. 21-25
    • Workman, P.1
  • 5
    • 0034677755 scopus 로고    scopus 로고
    • Mechanism-based target identification and drug discovery in cancer research
    • A timely review of new mechanism-based cancer drugs acting on novel molecular targets. Focuses on breast cancer as a paradigm.
    • Gibbs J.B. Mechanism-based target identification and drug discovery in cancer research. Science. 287:2000;1969-1973. A timely review of new mechanism-based cancer drugs acting on novel molecular targets. Focuses on breast cancer as a paradigm.
    • (2000) Science , vol.287 , pp. 1969-1973
    • Gibbs, J.B.1
  • 6
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome.
    • International Human Genome Sequencing Consortium. Landmark publication by the international public consortium, of the working draft of the human genome sequence. The availability of the genome sequence is revolutionising biology and medicine
    • International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 2001, 409:860-921. Landmark publication by the international public consortium, of the working draft of the human genome sequence. The availability of the genome sequence is revolutionising biology and medicine.
    • (2001) Nature , vol.409 , pp. 860-921
  • 8
    • 0003606583 scopus 로고    scopus 로고
    • London: Weidenfield and Nicolson; (Also published in the USA under the title Cracking the Genome: Inside the Race to Unlock Human DNA by The Free Press.). A description of the science, personalities and politics behind the sequencing of the human genome. Gives several examples of how the sequence benefits cancer research, including the discovery of new cancer genes and drug targets. Excellent reading at 35 000 feet
    • Davies K: The Sequence: Inside the Race for the Human Genome. London: Weidenfield and Nicolson; 2001. (Also published in the USA under the title Cracking the Genome: Inside the Race to Unlock Human DNA by The Free Press.). A description of the science, personalities and politics behind the sequencing of the human genome. Gives several examples of how the sequence benefits cancer research, including the discovery of new cancer genes and drug targets. Excellent reading at 35 000 feet.
    • (2001) The Sequence: Inside the Race for the Human Genome
    • Davies, K.1
  • 9
    • 0034614598 scopus 로고    scopus 로고
    • Genomic biology
    • An excellent review that illustrates how the practice of biology is revolutionised by genomics.
    • Brent R. Genomic biology. Cell. 100:2000;169-183. An excellent review that illustrates how the practice of biology is revolutionised by genomics.
    • (2000) Cell , vol.100 , pp. 169-183
    • Brent, R.1
  • 10
    • 0035865078 scopus 로고    scopus 로고
    • Human disease genes
    • A commentary on the implications of the discovery of human disease genes, which accompanied the publication of the human genome sequence.
    • Jiminez-Sanchez G., Childs B., Valle D. Human disease genes. Nature. 409:2001;853-855. A commentary on the implications of the discovery of human disease genes, which accompanied the publication of the human genome sequence.
    • (2001) Nature , vol.409 , pp. 853-855
    • Jiminez-Sanchez, G.1    Childs, B.2    Valle, D.3
  • 11
    • 0035865397 scopus 로고    scopus 로고
    • Our genome unveiled
    • General commentary on the human genome sequence.
    • Baltimore D. Our genome unveiled. Nature. 409:2001;814-815. General commentary on the human genome sequence.
    • (2001) Nature , vol.409 , pp. 814-815
    • Baltimore, D.1
  • 12
    • 0039379481 scopus 로고    scopus 로고
    • Editorial: The human genome, in proportion
    • A note of caution, setting the potential value of the genome sequence in the context of factors affecting human health world-wide and also the costs of healthcare
    • Editorial: The human genome, in proportion. Lancet 2001, 35: 74-89. A note of caution, setting the potential value of the genome sequence in the context of factors affecting human health world-wide and also the costs of healthcare.
    • (2001) Lancet , vol.35 , pp. 74-89
  • 13
    • 17744393015 scopus 로고    scopus 로고
    • Editorial: A cold dose of medicine
    • Another cautionary note, emphasising the need for greater understanding of proteomics and metabolic pathways, together with the challenge of moving from genes to drugs
    • Editorial: A cold dose of medicine. Nat Biotechnol 2001, 19: 181. Another cautionary note, emphasising the need for greater understanding of proteomics and metabolic pathways, together with the challenge of moving from genes to drugs.
    • (2001) Nat Biotechnol , vol.19 , pp. 181
  • 14
    • 0035865465 scopus 로고    scopus 로고
    • Cancer and genomics
    • An early look at the potential for discovery of new cancer genes using the published working draft of the human genome sequence and the available cancer genome sequences. This illustrates the need for high-quality genome-wide sequencing of the genomes of cancer cells and tissues.
    • Futreal P.A., Ksprzyk A., Birney E., Mullikin J.C., Wooster R., Stratton M.R. Cancer and genomics. Nature. 409:2001;850-855. An early look at the potential for discovery of new cancer genes using the published working draft of the human genome sequence and the available cancer genome sequences. This illustrates the need for high-quality genome-wide sequencing of the genomes of cancer cells and tissues.
    • (2001) Nature , vol.409 , pp. 850-855
    • Futreal, P.A.1    Ksprzyk, A.2    Birney, E.3    Mullikin, J.C.4    Wooster, R.5    Stratton, M.R.6
  • 15
    • 0035069825 scopus 로고    scopus 로고
    • Editorial: All hands on deck at dawn
    • A commentary on the Oncogenomics Conference. (Tucson, Arizona 25-27 January 2001). Held just before the publication of the draft human genome sequence, the meeting provided a preview of the highlights and an opportunity to discuss the implications for cancer research and therapy
    • Editorial: All hands on deck at dawn. Nat Genet 2001, 27:347-349. A commentary on the Oncogenomics Conference. (Tucson, Arizona 25-27 January 2001). Held just before the publication of the draft human genome sequence, the meeting provided a preview of the highlights and an opportunity to discuss the implications for cancer research and therapy.
    • (2001) Nat Genet , vol.27 , pp. 347-349
  • 16
    • 0035105588 scopus 로고    scopus 로고
    • Gazing into a crystal ball - Cancer therapy in the post-genome era
    • A thoughtful commentary that predicts that genome sequencing, the discovery of cancer genes and the elucidation of the molecular pathogenesis of cancer will lead to an age of individually tailored drugs - but it will take time for this to impact on routine cancer therapy.
    • Ratain M.J., Relling M.V. Gazing into a crystal ball - cancer therapy in the post-genome era. Nat Med. 7:2001;283-285. A thoughtful commentary that predicts that genome sequencing, the discovery of cancer genes and the elucidation of the molecular pathogenesis of cancer will lead to an age of individually tailored drugs - but it will take time for this to impact on routine cancer therapy.
    • (2001) Nat Med , vol.7 , pp. 283-285
    • Ratain, M.J.1    Relling, M.V.2
  • 17
    • 0035931968 scopus 로고    scopus 로고
    • Genome-wide views of cancer
    • This editorial discusses issues around the impact of genomics on cancer diagnosis and therapy, with particular reference to DNA microarrays in general and the transcriptional signatures of mutant BRCA1 and BRCA2 in particular.
    • Golub T.R. Genome-wide views of cancer. New Engl J Med. 344:2001;601-602. This editorial discusses issues around the impact of genomics on cancer diagnosis and therapy, with particular reference to DNA microarrays in general and the transcriptional signatures of mutant BRCA1 and BRCA2 in particular.
    • (2001) New Engl J Med , vol.344 , pp. 601-602
    • Golub, T.R.1
  • 18
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • One of the first published studies determining global gene expression profiles in human tumours, in this case for breast cancer.
    • Perou C.M., Serlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., Pollack J.R., Ross D.T., Johnsen H., Akslen L.A., et al. Molecular portraits of human breast tumours. Nature. 406:2000;747-752. One of the first published studies determining global gene expression profiles in human tumours, in this case for breast cancer.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Serlie, T.2    Eisen, M.B.3    Van De Rijn, M.4    Jeffrey, S.S.5    Rees, C.A.6    Pollack, J.R.7    Ross, D.T.8    Johnsen, H.9    Akslen, L.A.10
  • 19
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Another early determination of gene expression profiles in human cancer. This example, in lymphoma, illustrates the ability to discover and predict subclasses within that tumour type.
    • Golub T.R., Slonim D.K., Tamayo P., Huard C., Gaasenbeek M., Mesirov J.P., Coller H., Loh M.L., Downing J.R., Caligiuri M.A., et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 286:1999;531-537. Another early determination of gene expression profiles in human cancer. This example, in lymphoma, illustrates the ability to discover and predict subclasses within that tumour type.
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3    Huard, C.4    Gaasenbeek, M.5    Mesirov, J.P.6    Coller, H.7    Loh, M.L.8    Downing, J.R.9    Caligiuri, M.A.10
  • 20
    • 0033399457 scopus 로고    scopus 로고
    • Gene expression profiling in drug discovery
    • A valuable review illustrating the power of gene expression profiling - a technique that will impact on all phases of target and drug discovery.
    • Stratowa C., Wilgenbus K.K. Gene expression profiling in drug discovery. Curr Opin Mol Ther. 1:1999;671-679. A valuable review illustrating the power of gene expression profiling - a technique that will impact on all phases of target and drug discovery.
    • (1999) Curr Opin Mol Ther , vol.1 , pp. 671-679
    • Stratowa, C.1    Wilgenbus, K.K.2
  • 21
    • 0034050902 scopus 로고    scopus 로고
    • Systematic variation in gene expression patterns in human cancer cell lines
    • Characterisation of gene expression patterns using DNA microarrays in the US National Cancer Institute's panel of 60 human tumour cell lines
    • Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, et al.: Systematic variation in gene expression patterns in human cancer cell lines, Nat Genet, 24:227-235. Characterisation of gene expression patterns using DNA microarrays in the US National Cancer Institute's panel of 60 human tumour cell lines.
    • Nat Genet , vol.24 , pp. 227-235
    • Ross, D.T.1    Scherf, U.2    Eisen, M.B.3    Perou, C.M.4    Rees, C.5    Spellman, P.6    Iyer, V.7    Jeffrey, S.S.8    Van De Rijn, M.9    Waltham, M.10
  • 22
    • 0034050902 scopus 로고    scopus 로고
    • A gene expression database for the molecular pharmacology of cancer
    • Describes the use of informatics programmes to mine the gene expression database (from [21•]) and determine correlations with sensitivity to >10 000 compounds in the 60 cell line panel.
    • Scherf U., Ross D.T., Waltham M., Smith L.H., Lee J.K., Tanabe L., Kohn K.W., Reinhold W.C., Myers T.G., Andrews D.T., et al. A gene expression database for the molecular pharmacology of cancer. Nat Genet. 24:2000;227-235. Describes the use of informatics programmes to mine the gene expression database (from [21•]) and determine correlations with sensitivity to >10 000 compounds in the 60 cell line panel.
    • (2000) Nat Genet , vol.24 , pp. 227-235
    • Scherf, U.1    Ross, D.T.2    Waltham, M.3    Smith, L.H.4    Lee, J.K.5    Tanabe, L.6    Kohn, K.W.7    Reinhold, W.C.8    Myers, T.G.9    Andrews, D.T.10
  • 23
    • 0035912171 scopus 로고    scopus 로고
    • When the chips are down
    • An important news feature that points out inaccuracies in gene identity on microarrays.
    • Knight J. When the chips are down. Nature. 410:2001;860-861. An important news feature that points out inaccuracies in gene identity on microarrays.
    • (2001) Nature , vol.410 , pp. 860-861
    • Knight, J.1
  • 24
    • 0033891762 scopus 로고    scopus 로고
    • Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray
    • One of the first papers to use microarrays to determine global gene expresion changes in response to drug treatment - in this case for the cytotoxic agent doxorubicin.
    • Kudoh K., Ramanna M., Ravatn R., Elkahloun A.G., Bittner E.L., Meltzer P.S., Trent J.M., Dalton W.S., Chin K.V. Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray. Cancer Res. 60:2000;4161-4166. One of the first papers to use microarrays to determine global gene expresion changes in response to drug treatment - in this case for the cytotoxic agent doxorubicin.
    • (2000) Cancer Res , vol.60 , pp. 4161-4166
    • Kudoh, K.1    Ramanna, M.2    Ravatn, R.3    Elkahloun, A.G.4    Bittner, E.L.5    Meltzer, P.S.6    Trent, J.M.7    Dalton, W.S.8    Chin, K.V.9
  • 25
    • 0034710542 scopus 로고    scopus 로고
    • Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxy geldanamycin, an inhibitor of the Hsp90 molecular chaperone
    • Another of the first papers to use microarrays to determine global gene expression changes in response to drug treatment - here the agent is the Hsp90 molecular chaperone inhibitor 17AAG. This study identified genes that may be useful in predicting sensitivity to the drug, as well as pharmacodynamic response markers.
    • Clarke P.A., Hostein I., Banerji U., Di Stefano F., Maloney A., Walton M., Judson I., Workman P. Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxy geldanamycin, an inhibitor of the Hsp90 molecular chaperone. Oncogene. 19:2000;4125-4133. Another of the first papers to use microarrays to determine global gene expression changes in response to drug treatment - here the agent is the Hsp90 molecular chaperone inhibitor 17AAG. This study identified genes that may be useful in predicting sensitivity to the drug, as well as pharmacodynamic response markers.
    • (2000) Oncogene , vol.19 , pp. 4125-4133
    • Clarke, P.A.1    Hostein, I.2    Banerji, U.3    Di Stefano, F.4    Maloney, A.5    Walton, M.6    Judson, I.7    Workman, P.8
  • 26
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Creating cancerous human epithelial cells in the laboratory by deregulating the function of four critical genes: Harvey Ras, p53, Rb and the telomerase catalytic subunit hTERT.
    • Hahn W.C., Counter C.M., Lundberg A.S., Bijersbergen R.L., Brooks M.W., Weinberg R.A. Creation of human tumour cells with defined genetic elements. Nature. 400:1999;464-468. Creating cancerous human epithelial cells in the laboratory by deregulating the function of four critical genes: Harvey Ras, p53, Rb and the telomerase catalytic subunit hTERT.
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1    Counter, C.M.2    Lundberg, A.S.3    Bijersbergen, R.L.4    Brooks, M.W.5    Weinberg, R.A.6
  • 27
    • 0027401607 scopus 로고
    • The multistep nature of cancer
    • Vogelstein B., Kinzler K. The multistep nature of cancer. Trends Genet. 9:1993;138-141.
    • (1993) Trends Genet , vol.9 , pp. 138-141
    • Vogelstein, B.1    Kinzler, K.2
  • 28
    • 0035895513 scopus 로고    scopus 로고
    • What if there are only 30 000 human genes?
    • An interesting discussion of the predicted human gene count.
    • Claverie J.M. What if there are only 30 000 human genes? Science. 291:2001;1255-1257. An interesting discussion of the predicted human gene count.
    • (2001) Science , vol.291 , pp. 1255-1257
    • Claverie, J.M.1
  • 29
    • 0035106880 scopus 로고    scopus 로고
    • Piecing together the significance of splice
    • A commentary on significance of splice variants.
    • Sorek R., Amitai M. Piecing together the significance of splice. Nat Biotechnol. 19:2001;196. A commentary on significance of splice variants.
    • (2001) Nat Biotechnol , vol.19 , pp. 196
    • Sorek, R.1    Amitai, M.2
  • 30
    • 0030274647 scopus 로고    scopus 로고
    • Genomic sciences and the medicine of tomorrow
    • Drews J. Genomic sciences and the medicine of tomorrow. Nat Biotechnol. 14:1996;1518-1519.
    • (1996) Nat Biotechnol , vol.14 , pp. 1518-1519
    • Drews, J.1
  • 31
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • An update on the classic commentary [30].
    • Drews J. Drug discovery: a historical perspective. Science. 287:2000;1960-1964. An update on the classic commentary [30].
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 32
    • 0035286796 scopus 로고    scopus 로고
    • The end of the beginning for genomic medicine
    • An interesting commentary that suggests that the number of new drug targets may exceed the original estimate of 6-10 000 despite the reduction in the predicted human gene count.
    • Bailey D., Zanders E., Dean P. The end of the beginning for genomic medicine. Nat Biotechnol. 19:2001;207-209. An interesting commentary that suggests that the number of new drug targets may exceed the original estimate of 6-10 000 despite the reduction in the predicted human gene count.
    • (2001) Nat Biotechnol , vol.19 , pp. 207-209
    • Bailey, D.1    Zanders, E.2    Dean, P.3
  • 33
    • 0033287914 scopus 로고    scopus 로고
    • Combinatorial chemistry as a tool for drug discovery
    • A review of combinatorial chemistry that is relatively accessible for bioscientists.
    • Floyd C., Le Blanc C., Whittaker M. Combinatorial chemistry as a tool for drug discovery. Prog Med Chem. 36:1999;91-167. A review of combinatorial chemistry that is relatively accessible for bioscientists.
    • (1999) Prog Med Chem , vol.36 , pp. 91-167
    • Floyd, C.1    Le Blanc, C.2    Whittaker, M.3
  • 34
    • 0033683359 scopus 로고    scopus 로고
    • Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry
    • A more detailed review of technical developments in combinatorial chemistry.
    • Gullier F., Orain D., Bradley M. Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry. Chem Rev. 100:2000;2091-2157. A more detailed review of technical developments in combinatorial chemistry.
    • (2000) Chem Rev , vol.100 , pp. 2091-2157
    • Gullier, F.1    Orain, D.2    Bradley, M.3
  • 35
    • 0034678033 scopus 로고    scopus 로고
    • Target-oriented and diversity-oriented organic synthesis in drug discovery
    • Describes approaches for planning, by retrosynthetic analysis, both diversity-oriented synthetic libraries and more focused target-oriented libraries for drug discovery.
    • Schreiber S.L. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. 287:2000;1964-1969. Describes approaches for planning, by retrosynthetic analysis, both diversity-oriented synthetic libraries and more focused target-oriented libraries for drug discovery.
    • (2000) Science , vol.287 , pp. 1964-1969
    • Schreiber, S.L.1
  • 36
    • 0035132538 scopus 로고    scopus 로고
    • Characterisation of the antitumour effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
    • An example of a farnesyl transferase inhibitor, these results suggest that antitumour activity may be due, in part, to effects on host-tumour interactions.
    • End D.W., Smets G., Todd A.V., Applegate T.L., Fuery C.J., Angibaud P., Venet M., Sanz G., Poignet H., Skrzat S., et al. Characterisation of the antitumour effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61:2000;131-137. An example of a farnesyl transferase inhibitor, these results suggest that antitumour activity may be due, in part, to effects on host-tumour interactions.
    • (2000) Cancer Res , vol.61 , pp. 131-137
    • End, D.W.1    Smets, G.2    Todd, A.V.3    Applegate, T.L.4    Fuery, C.J.5    Angibaud, P.6    Venet, M.7    Sanz, G.8    Poignet, H.9    Skrzat, S.10
  • 37
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • A review of farnesyl transferase inhibitors.
    • Rowinsky E.K., Windle J.J., Von Hoff D.D. Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J Clin Oncol. 17:1999;3631-3652. A review of farnesyl transferase inhibitors.
    • (1999) J Clin Oncol , vol.17 , pp. 3631-3652
    • Rowinsky, E.K.1    Windle, J.J.2    Von Hoff, D.D.3
  • 38
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • An up-to-date and readable review of p53.
    • Vogelstein B., Lane D., Levine A.J. Surfing the p53 network. Nature. 408:2000;307-312. An up-to-date and readable review of p53.
    • (2000) Nature , vol.408 , pp. 307-312
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 39
    • 0033831080 scopus 로고    scopus 로고
    • A controlled trial of intratumoral Onyx-O15, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
    • This paper describes progress in the clinical development of the Onyx adenovirus which selectively replicates in, and kills, tumour cells that lack p53 function.
    • Khuri F.R., Nemunaitis J., Ganly I., Arseneau J., Tannock I.F., Romel L., Gore M., Ironside J., MacDougall R.H., Heise C., et al. A controlled trial of intratumoral Onyx-O15, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med. 6:2000;879-885. This paper describes progress in the clinical development of the Onyx adenovirus which selectively replicates in, and kills, tumour cells that lack p53 function.
    • (2000) Nat Med , vol.6 , pp. 879-885
    • Khuri, F.R.1    Nemunaitis, J.2    Ganly, I.3    Arseneau, J.4    Tannock, I.F.5    Romel, L.6    Gore, M.7    Ironside, J.8    MacDougall, R.H.9    Heise, C.10
  • 40
    • 0033543728 scopus 로고    scopus 로고
    • A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
    • Discovery through screening, of a small molecule (pifithrin-α), that inhibits p53-dependent gene expression and protects against the side-effects of DNA-damaging agents.
    • Komarov P.G., Komarov E.A., Kondratov R.V., Christov-Tselkov K., Coon J.S., Chemov M.V., Gudkov A.V. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 285:1999;1733-1737. Discovery through screening, of a small molecule (pifithrin-α), that inhibits p53-dependent gene expression and protects against the side-effects of DNA-damaging agents.
    • (1999) Science , vol.285 , pp. 1733-1737
    • Komarov, P.G.1    Komarov, E.A.2    Kondratov, R.V.3    Christov-Tselkov, K.4    Coon, J.S.5    Chemov, M.V.6    Gudkov, A.V.7
  • 41
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • Another approach to cancer therapy based on p53. Here, screening was used to discover small molecules that stabilize mutant p53 in the wild-type, functionally active conformation. These agents show antitumour activity in cancer models in vivo.
    • Foster B.A., Coffey H.A., Morin M.J., Rastinejad F. Pharmacological rescue of mutant p53 conformation and function. Science. 286:1999;2507-2510. Another approach to cancer therapy based on p53. Here, screening was used to discover small molecules that stabilize mutant p53 in the wild-type, functionally active conformation. These agents show antitumour activity in cancer models in vivo.
    • (1999) Science , vol.286 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3    Rastinejad, F.4
  • 42
    • 0033179183 scopus 로고    scopus 로고
    • Recognising molecules with drug- like properties
    • Designing 'drug-like' behaviour into a lead series is a major hurdle in drug discovery. This review summarises the development of tools to enrich chemical libraries for these desirable properties.
    • Walters W.P., Ajay, Murcko M.A. Recognising molecules with drug- like properties. Curr Opin Chem Biol. 3:1999;384-387. Designing 'drug-like' behaviour into a lead series is a major hurdle in drug discovery. This review summarises the development of tools to enrich chemical libraries for these desirable properties.
    • (1999) Curr Opin Chem Biol , vol.3 , pp. 384-387
    • Walters, W.P.1    Ajay2    Murcko, M.A.3
  • 43
    • 0040564565 scopus 로고    scopus 로고
    • Cassette dosing pharmacokinetics for 107 analogue of the trisubstituted purine CDK2 inhibitor Roscovitine
    • This abstract exemplifies the value of using cassette dosing to select anticancer compounds with good pharmacokinetic properties.
    • Raynaud F.I., Goddard P., Fischer P., McClue S., Workman P. Cassette dosing pharmacokinetics for 107 analogue of the trisubstituted purine CDK2 inhibitor Roscovitine. Proc Am Assoc Cancer Res. 42:2001;382. This abstract exemplifies the value of using cassette dosing to select anticancer compounds with good pharmacokinetic properties.
    • (2001) Proc Am Assoc Cancer Res , vol.42 , pp. 382
    • Raynaud, F.I.1    Goddard, P.2    Fischer, P.3    McClue, S.4    Workman, P.5
  • 44
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • A superb and highly readable review of the molecular causes of cancer.
    • Hanahan D., Weinberg A. The hallmarks of cancer. Cell. 100:2000;57-70. A superb and highly readable review of the molecular causes of cancer.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, A.2
  • 45
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitski A., Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science. 267:1995;1782-1788.
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitski, A.1    Gazit, A.2
  • 46
    • 0029850505 scopus 로고    scopus 로고
    • In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022
    • McLeod A.L., Brunton V.G., Eckhardt N., Lear M.J., Robins D.J. In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022. Br J Cancer. 74:1996;1714-1718.
    • (1996) Br J Cancer , vol.74 , pp. 1714-1718
    • McLeod, A.L.1    Brunton, V.G.2    Eckhardt, N.3    Lear, M.J.4    Robins, D.J.5
  • 48
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • A much anticipated Phase 1 study report describing the exciting results obtained with the Bcr-Abl kinase inhibitor Glivec® in chronic myeloid leukaemia. Provides proof of principle for the development of anticancer drugs based on a specific molecular abnormality that drives the particular cancer.
    • Druker B.J., Talpaz M., Rest D.J., Peng B., Buchdunger E., Ford J.M., Lydon N.B., Kantarjian H., Capdeville R., Ohno-Jones S., Sawyers C.L. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. New Engl J Med. 344:2001;1031-1037. A much anticipated Phase 1 study report describing the exciting results obtained with the Bcr-Abl kinase inhibitor Glivec® in chronic myeloid leukaemia. Provides proof of principle for the development of anticancer drugs based on a specific molecular abnormality that drives the particular cancer.
    • (2001) New Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Rest, D.J.3    Peng, B.4    Buchdunger, E.5    Ford, J.M.6    Lydon, N.B.7    Kantarjian, H.8    Capdeville, R.9    Ohno-Jones, S.10    Sawyers, C.L.11
  • 49
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Confirmation that Glivec® is well tolerated and active in chronic myeloid leukemia, including the blast crisis phase, and also in Philadelphia chromosome positive acute lymphocytic leukaemia.
    • Druker B.J., Sawyers C.L., Kantarjian H., Resta D.J., Reese S.F., Ford J.M., Capdeville R., Talpaz M. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. New Engl J Med. 344:2001;1038-1042. Confirmation that Glivec® is well tolerated and active in chronic myeloid leukemia, including the blast crisis phase, and also in Philadelphia chromosome positive acute lymphocytic leukaemia.
    • (2001) New Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5    Ford, J.M.6    Capdeville, R.7    Talpaz, M.8
  • 50
    • 0034665713 scopus 로고    scopus 로고
    • Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase
    • A structural explanation for the inhibition of the Abl tyrosine kinase by Glivec®.
    • Schinder T., Bornmann W., Pellicena P., Miller W.T., Clarkson B., Kuriyan J. Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science. 289:2000;1938-1941. A structural explanation for the inhibition of the Abl tyrosine kinase by Glivec®.
    • (2000) Science , vol.289 , pp. 1938-1941
    • Schinder, T.1    Bornmann, W.2    Pellicena, P.3    Miller, W.T.4    Clarkson, B.5    Kuriyan, J.6
  • 51
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibtior ST1571 in a patient with a metastatic gastrointestinal stromal tumor
    • Demonstration of the potential for Glivec® activity in GIST tumours that have activated c-kit tyrosine kinase.
    • Joensuu H., Roberts P.J., Sarlomo-Rikala M., Andersson L.C., Tervahartiala P., Tuveson D., Silberman S.L., Capdeville R., Dimitrijevic S., Druker B.J., Demetri G.D. Effect of the tyrosine kinase inhibtior ST1571 in a patient with a metastatic gastrointestinal stromal tumor. New Engl J Med. 344:2001;1052-1056. Demonstration of the potential for Glivec® activity in GIST tumours that have activated c-kit tyrosine kinase.
    • (2001) New Engl J Med , vol.344 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3    Andersson, L.C.4    Tervahartiala, P.5    Tuveson, D.6    Silberman, S.L.7    Capdeville, R.8    Dimitrijevic, S.9    Druker, B.J.10    Demetri, G.D.11
  • 52
    • 0033763084 scopus 로고    scopus 로고
    • ZD1839 ('Iressa') as an anticancer agent
    • Iressa is showing promising clinical activity as an inhibitor of the EGF receptor tyrosine kinase.
    • Baselga J., Averbuch S.D. ZD1839 ('Iressa') as an anticancer agent. Drugs. 60:2000;33-40. Iressa is showing promising clinical activity as an inhibitor of the EGF receptor tyrosine kinase.
    • (2000) Drugs , vol.60 , pp. 33-40
    • Baselga, J.1    Averbuch, S.D.2
  • 53
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • This paper shows a survival advantage for the use of the anti-erbB2 antibody Herceptin® when used as part of combination chemotherapy for the treatment of metastatic breast cancer.
    • Slamon D., Leyland-Jones B., Shak S., Fuchs H., Paton V., Bajamonde A., Fleming T., Eiermann W., Wolter J., Pegram M., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. New Engl J Med. 344:2001;783-792. This paper shows a survival advantage for the use of the anti-erbB2 antibody Herceptin® when used as part of combination chemotherapy for the treatment of metastatic breast cancer.
    • (2001) New Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.1    Leyland-Jones, B.2    Shak, S.3    Fuchs, H.4    Paton, V.5    Bajamonde, A.6    Fleming, T.7    Eiermann, W.8    Wolter, J.9    Pegram, M.10
  • 54
    • 0034033642 scopus 로고    scopus 로고
    • Inhibitors of cyclin-dependent kinases as therapeutic agents for the treatment of cancer
    • An up-to-date review of the discovery of cyclin-dependent kinase targets and inhibitors acting on these.
    • Fry D.W., Garrett M.D. Inhibitors of cyclin-dependent kinases as therapeutic agents for the treatment of cancer. Curr Opin Oncol Endocrine Metab Invest Drugs. 2:2000;40-59. An up-to-date review of the discovery of cyclin-dependent kinase targets and inhibitors acting on these.
    • (2000) Curr Opin Oncol Endocrine Metab Invest Drugs , vol.2 , pp. 40-59
    • Fry, D.W.1    Garrett, M.D.2
  • 55
    • 0033856462 scopus 로고    scopus 로고
    • PI3-kinase inhibition: A target for drug development?
    • A commentary that explores the potential of PI3Ks as drug targets.
    • Stein R.C., Waterfield M.D. PI3-kinase inhibition: a target for drug development? Mol Med Today. 6:2000;347-357. A commentary that explores the potential of PI3Ks as drug targets.
    • (2000) Mol Med Today , vol.6 , pp. 347-357
    • Stein, R.C.1    Waterfield, M.D.2
  • 56
    • 0033579175 scopus 로고    scopus 로고
    • DT-diaphorase expression and tumour cell sensitivity to 17-allylamino,17-demethoxygeldanamycin, an inhibitor of heat shock protein 90
    • Demonstration of the antitumour activity of the Hsp90 inhibitor 17AAG against human tumour xenografts, and the role of DT-diaphorase in tumour sensitivity to this inhibition.
    • Kelland L.R., Sharp S.Y., Rogers P.M., Myers T.G., Workman P. DT-diaphorase expression and tumour cell sensitivity to 17-allylamino,17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst. 91:1999;1940-1949. Demonstration of the antitumour activity of the Hsp90 inhibitor 17AAG against human tumour xenografts, and the role of DT-diaphorase in tumour sensitivity to this inhibition.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1940-1949
    • Kelland, L.R.1    Sharp, S.Y.2    Rogers, P.M.3    Myers, T.G.4    Workman, P.5
  • 57
    • 0035872442 scopus 로고    scopus 로고
    • Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis
    • Hostein I., Robertson D., Di Stefano F., Workman P., Clarke P.A. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 61:2001;4003-4009.
    • (2001) Cancer Res , vol.61 , pp. 4003-4009
    • Hostein, I.1    Robertson, D.2    Di Stefano, F.3    Workman, P.4    Clarke, P.A.5
  • 58
    • 0033000990 scopus 로고    scopus 로고
    • Histone acetylases and deacetylases in cell proliferation
    • A review of the key role played by mammalian HATs and HDACs in the control of gene transcription and cell proliferation, also highlighting their potentially causative role in cancer.
    • Kouzarides T. Histone acetylases and deacetylases in cell proliferation. Curr Opin Genet Dev. 9:1999;40-48. A review of the key role played by mammalian HATs and HDACs in the control of gene transcription and cell proliferation, also highlighting their potentially causative role in cancer.
    • (1999) Curr Opin Genet Dev , vol.9 , pp. 40-48
    • Kouzarides, T.1
  • 59
    • 0034654011 scopus 로고    scopus 로고
    • Acetylation: A regulatory modification to rival phosphorylation?
    • A timely review proposing the analogy between acetylation and phosphorylation as ubiquitous methods of controlling cellular events. In rivalling kinases and phosphatases in this regard, HATs and HDACs are poised to become the next important class of drug targets in cancer and other therapeutic areas.
    • Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation? EMBO J. 19:2000;1176-1179. A timely review proposing the analogy between acetylation and phosphorylation as ubiquitous methods of controlling cellular events. In rivalling kinases and phosphatases in this regard, HATs and HDACs are poised to become the next important class of drug targets in cancer and other therapeutic areas.
    • (2000) EMBO J , vol.19 , pp. 1176-1179
    • Kouzarides, T.1
  • 60
    • 0034104047 scopus 로고    scopus 로고
    • Mutations truncating EP300 acetylase in human cancers
    • Truncating mutations in the gene encoding the HAT p300 were detected in 6 out of 193 epithelial cancers (6%). Such evidence for genetic deregulation of HATs and HDACs contributes to their validation as potential drug targets.
    • Gayther S.A., Batley S.J., Linger L., Bannister A., Thorpe K., Suet-Feung C., Diago Y., Russell P., Wilson A., Sowter H.M., et al. Mutations truncating EP300 acetylase in human cancers. Nat Genet. 24:2000;300-303. Truncating mutations in the gene encoding the HAT p300 were detected in 6 out of 193 epithelial cancers (6%). Such evidence for genetic deregulation of HATs and HDACs contributes to their validation as potential drug targets.
    • (2000) Nat Genet , vol.24 , pp. 300-303
    • Gayther, S.A.1    Batley, S.J.2    Linger, L.3    Bannister, A.4    Thorpe, K.5    Suet-Feung, C.6    Diago, Y.7    Russell, P.8    Wilson, A.9    Sowter, H.M.10
  • 61
    • 0033551152 scopus 로고    scopus 로고
    • A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumour activity against human tumours
    • Exemplifies the ability to design synthetic, small-molecule inhibitors of HDACs which have excellent pharmacokinetic properties and show good antitumour activity and therapeutic indices in cancer models.
    • Saito A., Yamashita T., Mariko Y., Nosaka Y., Tsuchiya K., Ando T., Suziki T., Tsuruo T., Nakashini O. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumour activity against human tumours. Proc Natl Acad Sci USA. 96:1999;4592-4597. Exemplifies the ability to design synthetic, small-molecule inhibitors of HDACs which have excellent pharmacokinetic properties and show good antitumour activity and therapeutic indices in cancer models.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4592-4597
    • Saito, A.1    Yamashita, T.2    Mariko, Y.3    Nosaka, Y.4    Tsuchiya, K.5    Ando, T.6    Suziki, T.7    Tsuruo, T.8    Nakashini, O.9
  • 62
    • 0033714888 scopus 로고    scopus 로고
    • HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF
    • The feasibility of discovering selective HAT inhibitors is exemplified using peptide-acetyl coenzyme A conjugates.
    • Lau O.D., Kundu T.K., Soccio R.E., Ait-Si-Ali S., Khalil E.M., Vassilev A., Wolffe A.P., Moran E. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell. 5:2000;589-595. The feasibility of discovering selective HAT inhibitors is exemplified using peptide-acetyl coenzyme A conjugates.
    • (2000) Mol Cell , vol.5 , pp. 589-595
    • Lau, O.D.1    Kundu, T.K.2    Soccio, R.E.3    Ait-Si-Ali, S.4    Khalil, E.M.5    Vassilev, A.6    Wolffe, A.P.7    Moran, E.8
  • 63
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • This review develops the concept - known as the histone code - that a range of covalent modifications on the tail domains of histone proteins act in a sequential and combinatorial manner to regulate chromatin structure and gene transcription, thereby controlling cell fate.
    • Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature. 403:2000;41-45. This review develops the concept - known as the histone code - that a range of covalent modifications on the tail domains of histone proteins act in a sequential and combinatorial manner to regulate chromatin structure and gene transcription, thereby controlling cell fate.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 64
    • 0034730745 scopus 로고    scopus 로고
    • Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila
    • II250, is shown to ubiquitinate histone H1 in a way that is essential for orderly gene expression in Drosophila.
    • II250, is shown to ubiquitinate histone H1 in a way that is essential for orderly gene expression in Drosophila.
    • (2000) Science , vol.289 , pp. 2357-2360
    • Pham, A.D.1    Sauer, F.2
  • 65
    • 0034730298 scopus 로고    scopus 로고
    • New insights into an old modification
    • A commentary on the paper by Pharm and Sauer [64•], setting it in the context of the histone code.
    • Mizzen C.A., Allis D. New insights into an old modification. Science. 289:2000;2290-2291. A commentary on the paper by Pharm and Sauer [64•], setting it in the context of the histone code.
    • (2000) Science , vol.289 , pp. 2290-2291
    • Mizzen, C.A.1    Allis, D.2
  • 66
    • 0035048449 scopus 로고    scopus 로고
    • Histone deacetylases induce angiogenesis by negative regulation of tumour suppressor genes
    • This paper reports that HDACs are induced by tumour hypoxia, leading to downregulation of the tumour supressor genes p53 and VHL. An HDAC inhibitor upregulated these genes and downregulated hypoxia-inducible factor 1α (HIF-1α) and VEGF, resulting in inhibition of angiogenesis. The results indicate that HDAC inhibitors may be anti-angiogenic as well as antiproliferative.
    • Kim M.S., Kwon H.J., Lee Y.M., Baek J.H., Jang J.E., Lee S.W., Moon E.J., Kim H.S., Lee S.K., Chung H.Y., et al. Histone deacetylases induce angiogenesis by negative regulation of tumour suppressor genes. Nat Med. 7:2001;437-443. This paper reports that HDACs are induced by tumour hypoxia, leading to downregulation of the tumour supressor genes p53 and VHL. An HDAC inhibitor upregulated these genes and downregulated hypoxia-inducible factor 1α (HIF-1α) and VEGF, resulting in inhibition of angiogenesis. The results indicate that HDAC inhibitors may be anti-angiogenic as well as antiproliferative.
    • (2001) Nat Med , vol.7 , pp. 437-443
    • Kim, M.S.1    Kwon, H.J.2    Lee, Y.M.3    Baek, J.H.4    Jang, J.E.5    Lee, S.W.6    Moon, E.J.7    Kim, H.S.8    Lee, S.K.9    Chung, H.Y.10
  • 67
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • An up-to-date commentary on angiogenesis and its therapeutic implications.
    • Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature. 407:2000;249-257. An up-to-date commentary on angiogenesis and its therapeutic implications.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 68
    • 0035283512 scopus 로고    scopus 로고
    • Telomerase inhibitors
    • A timely review of telomerase as a drug target and of progress with the discovery of telomerase inhibitors.
    • White L.K., Wright W.E., Shay J.W. Telomerase inhibitors. Trends Biotechnol. 19:2001;114-120. A timely review of telomerase as a drug target and of progress with the discovery of telomerase inhibitors.
    • (2001) Trends Biotechnol , vol.19 , pp. 114-120
    • White, L.K.1    Wright, W.E.2    Shay, J.W.3
  • 69
    • 0035942270 scopus 로고    scopus 로고
    • Structure-based design of selective and potent G-quadruplex-mediated telomerase inhibitors
    • An example of the discovery of telomerase inhibitors, in this case acting via G-quadruplex binding.
    • Read M., Harrison R.J., Romagnoli B., Tanious F.A., Gowan S.H., Reszka A.P., Wilson W.D., Kelland L.R., Neidle S. Structure-based design of selective and potent G-quadruplex-mediated telomerase inhibitors. Proc Natl Acad Sci USA. 98:2001;4844-4849. An example of the discovery of telomerase inhibitors, in this case acting via G-quadruplex binding.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4844-4849
    • Read, M.1    Harrison, R.J.2    Romagnoli, B.3    Tanious, F.A.4    Gowan, S.H.5    Reszka, A.P.6    Wilson, W.D.7    Kelland, L.R.8    Neidle, S.9
  • 70
    • 0034608786 scopus 로고    scopus 로고
    • Mitochondrion as a novel target of anticancer chemotherapy
    • A review of potential cancer drug targets in apoptotic signalling, with emphasis on mitochondrial involvement.
    • Constantini P., Jacotot E., Decaudin D., Kroemer G. Mitochondrion as a novel target of anticancer chemotherapy. J Natl Cancer Inst. 92:2000;1042-1053. A review of potential cancer drug targets in apoptotic signalling, with emphasis on mitochondrial involvement.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1042-1053
    • Constantini, P.1    Jacotot, E.2    Decaudin, D.3    Kroemer, G.4
  • 71
    • 0033941034 scopus 로고    scopus 로고
    • Innovation in the pharmaceutical industry
    • A strong critique of the ability of genomics and other new technologies to deliver innovative drugs.
    • Horrobin D.F. Innovation in the pharmaceutical industry. J R Soc Med. 93:2000;3412-3415. A strong critique of the ability of genomics and other new technologies to deliver innovative drugs.
    • (2000) J R Soc Med , vol.93 , pp. 3412-3415
    • Horrobin, D.F.1
  • 72
    • 0002793136 scopus 로고
    • Has R&D failed the pharmaceutical industry?
    • July/August
    • Brown P: Has R&D failed the pharmaceutical industry? Scrip Magazine 1994, July/August:3-4.
    • (1994) Scrip Magazine , pp. 3-4
    • Brown, P.1
  • 73
    • 0033523233 scopus 로고    scopus 로고
    • Anticancer agents targeting signalling molecules and cancer cell environment: Challenges for drug development
    • A commentary on current issues in cancer drug development, focusing on clinical trials of novel cytostatic agents.
    • Gelmon K.A., Eisenhauer E.A., Harris A.L., Ratain M.J., Workman P. Anticancer agents targeting signalling molecules and cancer cell environment: challenges for drug development. J Natl Cancer Inst. 19:1999;1281-1287. A commentary on current issues in cancer drug development, focusing on clinical trials of novel cytostatic agents.
    • (1999) J Natl Cancer Inst , vol.19 , pp. 1281-1287
    • Gelmon, K.A.1    Eisenhauer, E.A.2    Harris, A.L.3    Ratain, M.J.4    Workman, P.5
  • 74
    • 0033827119 scopus 로고    scopus 로고
    • Combinatorial chemoprevention of intestinal neoplasia
    • Demonstration of the value of combining an EGF receptor kinase inhibitor with a cyclooxygenase-2 (COX2) inhibitor in the chemoprevention of colorectal cancer.
    • Torrance C.J., Jackson P.E., Montgomery E., Kinzler K.W., Vogelstein B., Wissner A., Nunes M., Frost P., Discafan C. Combinatorial chemoprevention of intestinal neoplasia. Nat Med. 9:2000;1024-1028. Demonstration of the value of combining an EGF receptor kinase inhibitor with a cyclooxygenase-2 (COX2) inhibitor in the chemoprevention of colorectal cancer.
    • (2000) Nat Med , vol.9 , pp. 1024-1028
    • Torrance, C.J.1    Jackson, P.E.2    Montgomery, E.3    Kinzler, K.W.4    Vogelstein, B.5    Wissner, A.6    Nunes, M.7    Frost, P.8    Discafan, C.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.