메뉴 건너뛰기




Volumn 160, Issue 8, 1998, Pages 4004-4009

An antagonistic IL-4 mutant prevents type I allergy in the mouse: Inhibition of the IL-4/IL-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G3; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

EID: 0032522641     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (117)

References (36)
  • 1
    • 0025764757 scopus 로고
    • Interleukin-4: A prototypic immunoregulatory lymphokine
    • Paul, W. E. 1991. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77:1859.
    • (1991) Blood , vol.77 , pp. 1859
    • Paul, W.E.1
  • 2
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
    • (1996) Immunol. Today , vol.17 , pp. 138
    • Mosmann, T.R.1    Sad, S.2
  • 4
    • 0028176655 scopus 로고
    • Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
    • Zurawski, G., and J. E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today 15:19.
    • (1994) Immunol. Today , vol.15 , pp. 19
    • Zurawski, G.1    De Vries, J.E.2
  • 5
    • 0028126979 scopus 로고
    • Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency
    • Tony, H.-P., B.-J. Shen, P. Reusch, and W. Sebald. 1994. Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency. Eur. J. Biochem. 225:659.
    • (1994) Eur. J. Biochem. , vol.225 , pp. 659
    • Tony, H.-P.1    Shen, B.-J.2    Reusch, P.3    Sebald, W.4
  • 6
    • 0028909292 scopus 로고
    • Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor
    • Smerz-Bertling, C., and A. Duschl. 1995. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J. Biol. Chem. 270:966.
    • (1995) J. Biol. Chem. , vol.270 , pp. 966
    • Smerz-Bertling, C.1    Duschl, A.2
  • 7
    • 0026731478 scopus 로고
    • Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement
    • Kruse, N., H. P. Tony, and W. Sebald. 1992. Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement. EMBO J. 11:3237.
    • (1992) EMBO J. , vol.11 , pp. 3237
    • Kruse, N.1    Tony, H.P.2    Sebald, W.3
  • 8
    • 0027451432 scopus 로고
    • Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation
    • Kruse, N., B. J. Shen, S. Arnold, H. P. Tony, T. Müller, and W. Sebald. 1993. Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation. EMBO J. 12:5121.
    • (1993) EMBO J. , vol.12 , pp. 5121
    • Kruse, N.1    Shen, B.J.2    Arnold, S.3    Tony, H.P.4    Müller, T.5    Sebald, W.6
  • 9
    • 0027274890 scopus 로고
    • Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction
    • Zurawski, S. M., F. Vega, B. Huyghe, and G. Zurawski. 1993. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12:2663.
    • (1993) EMBO J. , vol.12 , pp. 2663
    • Zurawski, S.M.1    Vega, F.2    Huyghe, B.3    Zurawski, G.4
  • 10
    • 0027435159 scopus 로고
    • An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: Support for a common component shared by IL-4 and IL-13 receptors
    • Aversa, G., J. Punnonen, B. G. Cocks, R. de Waal Malefyt, F. Vega, S. M. Zurawski, G. Zurawski, and J. E. de Vries. 1993. An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors. J. Exp. Med. 178:2213.
    • (1993) J. Exp. Med. , vol.178 , pp. 2213
    • Aversa, G.1    Punnonen, J.2    Cocks, B.G.3    De Waal Malefyt, R.4    Vega, F.5    Zurawski, S.M.6    Zurawski, G.7    De Vries, J.E.8
  • 12
    • 0029088324 scopus 로고
    • Modulation of cell-bound and soluble CD23, spontaneous and ongoing IgE synthesis of human peripheral blood mononuclear cells by soluble IL-4 receptors and the partial antagonistic IL-4 mutant protein IL-4 (Y124D)
    • König, B., A. Fischer, and W. König. 1995. Modulation of cell-bound and soluble CD23, spontaneous and ongoing IgE synthesis of human peripheral blood mononuclear cells by soluble IL-4 receptors and the partial antagonistic IL-4 mutant protein IL-4 (Y124D). Immunology 85:604.
    • (1995) Immunology , vol.85 , pp. 604
    • König, B.1    Fischer, A.2    König, W.3
  • 14
    • 0029014158 scopus 로고
    • Inhibition of human IgE synthesis in vitro and in SCID-hu mice by an interleukin-4 receptor antagonist
    • Carballido, J. M., G. Aversa, D. Schols, J. Punnonen, and J. E. de Vries. 1995. Inhibition of human IgE synthesis in vitro and in SCID-hu mice by an interleukin-4 receptor antagonist. Int. Arch. Allergy Immunol. 107:304.
    • (1995) Int. Arch. Allergy Immunol. , vol.107 , pp. 304
    • Carballido, J.M.1    Aversa, G.2    Schols, D.3    Punnonen, J.4    De Vries, J.E.5
  • 15
    • 0029968650 scopus 로고    scopus 로고
    • Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common γ chain
    • Schnyder, B., S. Lugli, N. Feng, H. Etter, R. A. Lutz, B. Ryffel, K. Sugamura, H. Wunderli-Allenspach, and R. Moser. 1996. Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common γ chain. Blood 87:4286.
    • (1996) Blood , vol.87 , pp. 4286
    • Schnyder, B.1    Lugli, S.2    Feng, N.3    Etter, H.4    Lutz, R.A.5    Ryffel, B.6    Sugamura, K.7    Wunderli-Allenspach, H.8    Moser, R.9
  • 17
    • 15844404868 scopus 로고    scopus 로고
    • Interleukin-13 (IL-13) induces IL-I receptor antagonist gene expression and protein synthesis in peripheral blood mononuclear cells: Inhibition by an IL-4 mutant protein
    • Vannier, E., R. de Waal Malefyt, A. Salazar-Montes, J. E. de Vries, and C. A. Dinarello. 1996. Interleukin-13 (IL-13) induces IL-I receptor antagonist gene expression and protein synthesis in peripheral blood mononuclear cells: inhibition by an IL-4 mutant protein. Blood 8:3307.
    • (1996) Blood , vol.8 , pp. 3307
    • Vannier, E.1    De Waal Malefyt, R.2    Salazar-Montes, A.3    De Vries, J.E.4    Dinarello, C.A.5
  • 18
    • 0030950732 scopus 로고    scopus 로고
    • Interleukin-4 receptor complexes containing or lacking the γc chain are inhibited by an overlapping set of antagonistic interleukin-4 mutant proteins
    • Schnarr, B., J. Ezernieks, W. Sebald, and A. Duschl. 1997. Interleukin-4 receptor complexes containing or lacking the γc chain are inhibited by an overlapping set of antagonistic interleukin-4 mutant proteins. Int. Immunol. 9:861.
    • (1997) Int. Immunol. , vol.9 , pp. 861
    • Schnarr, B.1    Ezernieks, J.2    Sebald, W.3    Duschl, A.4
  • 19
    • 0031019987 scopus 로고    scopus 로고
    • A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction
    • Grunewald, S. M., S. Kunzmann, B. Schnarr, J. Ezernieks, W. Sebald, and A. Duschl. 1997. A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction. J. Biol. Chem. 272:1480.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1480
    • Grunewald, S.M.1    Kunzmann, S.2    Schnarr, B.3    Ezernieks, J.4    Sebald, W.5    Duschl, A.6
  • 20
    • 15444343191 scopus 로고    scopus 로고
    • Mouse macrophage development in the absence of the common γ chain: Defining receptor complexes responsible for IL-4 and IL-13 signaling
    • Andersson, A., S. M. Grunewald, A. Duschl, A. Fischer, and J. P. DiSanto. 1997. Mouse macrophage development in the absence of the common γ chain: defining receptor complexes responsible for IL-4 and IL-13 signaling. Eur. J. Immunol. 27:1762.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1762
    • Andersson, A.1    Grunewald, S.M.2    Duschl, A.3    Fischer, A.4    Disanto, J.P.5
  • 22
    • 0026719193 scopus 로고
    • Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway rcsponsiveness in the mouse
    • Renz, H., H. R. Smith, J. E. Henson, B. S. Ray, C. G. Irvin, and E. W. Gelfand. 1992. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway rcsponsiveness in the mouse. J. Allergy Clin. Immunol. 89:1127.
    • (1992) J. Allergy Clin. Immunol. , vol.89 , pp. 1127
    • Renz, H.1    Smith, H.R.2    Henson, J.E.3    Ray, B.S.4    Irvin, C.G.5    Gelfand, E.W.6
  • 28
    • 0030040387 scopus 로고    scopus 로고
    • Prevention of the development of immediate hypersensitivity and airway hyperresponsiveness following in vivo treatment with soluble IL-4 receptor
    • Renz, H., K. Bradley, K. Enssle, J. E. Loader, and E. W. Gelfand. 1996. Prevention of the development of immediate hypersensitivity and airway hyperresponsiveness following in vivo treatment with soluble IL-4 receptor. Int. Arch. Allergy Immunol. 109:167.
    • (1996) Int. Arch. Allergy Immunol. , vol.109 , pp. 167
    • Renz, H.1    Bradley, K.2    Enssle, K.3    Loader, J.E.4    Gelfand, E.W.5
  • 29
    • 0027239843 scopus 로고
    • Anti-cytokine antibodies as carrier proteins: Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes
    • Finkelman, F. D., K. B. Madden, S. C. Morris, J. M. Holmes, N. Boiani, I. M. Katona, and C. R. Maliszewski. 1993. Anti-cytokine antibodies as carrier proteins: prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol. 151:1235.
    • (1993) J. Immunol. , vol.151 , pp. 1235
    • Finkelman, F.D.1    Madden, K.B.2    Morris, S.C.3    Holmes, J.M.4    Boiani, N.5    Katona, I.M.6    Maliszewski, C.R.7
  • 30
    • 0027372064 scopus 로고
    • Mechanism and regulation of immunoglobulin isotype switching
    • Coffman, R. L., D. A. Lebman, and P. Rothman. 1993. Mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54:229.
    • (1993) Adv. Immunol. , vol.54 , pp. 229
    • Coffman, R.L.1    Lebman, D.A.2    Rothman, P.3
  • 33
    • 0029087972 scopus 로고
    • IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotope switch: Switching to γ1, γ3, and γ4, but not γ2
    • Fujieda, S., K. Zhang, and A. Saxon. 1995. IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotope switch: switching to γ1, γ3, and γ4, but not γ2. J. Immunol. 155:2318.
    • (1995) J. Immunol. , vol.155 , pp. 2318
    • Fujieda, S.1    Zhang, K.2    Saxon, A.3
  • 35
    • 0019499019 scopus 로고
    • Induction of adjuvant-independent IgE responses in inbred mice: Primary, secondary, and persistent IgE responses to Ovalbumin and Ovomucoid
    • Holt, P. G., A. H. Rose, J. E. Batty, and K. J. Turner. 1981. Induction of adjuvant-independent IgE responses in inbred mice: primary, secondary, and persistent IgE responses to Ovalbumin and Ovomucoid. Int. Arch. Allergy Appl. Immunol. 65: 42.
    • (1981) Int. Arch. Allergy Appl. Immunol. , vol.65 , pp. 42
    • Holt, P.G.1    Rose, A.H.2    Batty, J.E.3    Turner, K.J.4
  • 36
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kühn, R., K. Rajewsky, and W. Müller. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707.
    • (1991) Science , vol.254 , pp. 707
    • Kühn, R.1    Rajewsky, K.2    Müller, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.