A Novel Role for Murine IL-4 in Vivo: Induction of MUC5AC Gene Expression and Mucin Hypersecretion

American Journal of Respiratory Cell and Molecular Biology

Volumn 16, Issue 4, 1997, Pages 471-478

  Temann, U Angela ^b   Prasad, Bhagi ^b   Gallup, Marianne W ^b   Basbaum, Carol ^b   Ho, Samuel B ^b   Flavell, Richard A ^b   Rankin, John A ^a  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MURINAE; MUS MUSCULUS;

ALCIAN BLUE; INTERLEUKIN 4; MUCIN;

ANIMAL; ARTICLE; ELECTRON MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; LUNG; LUNG LAVAGE; METABOLISM; MOUSE; PERIODIC ACID SCHIFF STAIN; PHYSIOLOGY; SECRETION; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ALCIAN BLUE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; GENE EXPRESSION REGULATION; INTERLEUKIN-4; LUNG; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MUCINS; PERIODIC ACID-SCHIFF REACTION;

EID: 0031110215     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.16.4.9115759     Document Type: Article

References (44)

1. Aikawaa, T., S. Shimura, S. Hidetada, M. Ebina, and T. Takishima. 1992. Marked globet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest 101:916-921.
2. Larivee, P., S. J. Levine, R. D. Rieves, and J. H. Shelhamer. 1994. Airway inflammation and mucus hypersecretion. In Airway Secretion: Physiological Bases for the Control of Mucus Hypersecretion. S. Shimura and T. Takishima, editors. Marcel Dekker, New York, 469-511.
3. Lopez-Vidriero, M. T., and L. Reid. 1978. Chemical markers of mucous and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases. Am. Rev. Respir. Dis. 117: 465-477.
4. Lundgren, J. D., and J. H. Shelhamer. 1990. Pathogenesis of airway mucus hypersecretion. J. Allergy Clin. Immunol. 85:399-417.
5. Steiger, D. J., J. Hotchkiss, L. Bajaj, J. Harkema, and C. Basbaum. 1995. Concurrent increases in the storage and release of mucin-like molecules by rat airway epithelial cells in response to bacterial endotoxin. Am. J. Respir. Cell Mol. Biol. 12:307-314.
6. Jany, B., M. Gallup, T. Tsuda, and C. Basbaum. 1991. Mucin gene expression in rat airways following infection and irritation. Biochem. Biophys. Res. Comm. 181:1-8.
7. Larivee, P., S. J. Levine, A. Martinez, T. Wu, C. Logun, and J. H. Shelhamer. 1994. Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes. Am. J. Respir. Cell Mol. Biol. 11:199-205.
8. Sperber, K., P. Chanez, J. Bousquet, S. Santindra, and Z. Marom. 1995. Detection of a novel macrophage-derived mucus secretagogue (MMs-68) in bronchoalveolar lavage fluid of patients with asthma. J. Allergy Clin. Immunol. 95:868-876.
9. Kim, K. C., K. Wasano, R. M. Niles, J. E. Schuster, P. J. Stone, and J. S. Brody. 1987. Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc. Natl. Acad. Sci. USA 84:9304-9308.
10. Nadel, J. A. 1992. Role of mast cell and neutrophil proteases in airway secretion. Am. Rev. Respir. Dis. 144:S48-S51.
11. Sommerhoff, C. P., J. A. Nadel, C. B. Basbaum, and G. H. Caughey. 1990. Neutrophil elastase and cathespin G stimulate secretion from cultured bovine airway gland serous cells. J. Clin. Invest. 85:682-689.
12. Lundgren, J. D., R. T. Davey, B. Lundgren, J. Mullol, Z. Marom, C. Logun, J. Baraniuk, M. A. Kaliner, and J. H. Shelhamer. 1991. Eosinophil cationic protein stimulates and major basic protein inhibits airway mucus secretion. J. Allergy Clin. Immunol. 87:689-698.
13. Cohan, V. L., A. L. Scott, and C. A. Dinarello. 1991. Interleukin-1 is a mucus secretagogue. Cell. Immunol. 136:425-434.
14. Arnold, J. W., G. R. Klimpel, and D. W. Niesel. 1993. Tumor necrosis factor (TNF-alpha) regulates intestinal mucus production during salmonellosis. Cell. Immunol. 151:336-344.
15. Howard, M., J. Farrar, M. Hilfiker, B. Johnson, K. Takatsu, T. Hamaoka, and W. E. Paul. 1982. Identification of a T-cell derived B-cell growth factor distinct from interleukin 2. J. Exp. Med. 155:914-923.
16. Paul, W. E. 1991. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77:1859-1870.
17. Geha, R. S. 1992. Atopic allergy and other hypersensitivities. Curr. Opin. Immunol. 4:779-781.
18. Rankin, J. A., D. E. Picarella, G. Geba, U.-A. Temann, B. Prasad, B. DiCosmo, A. Tarallo, B. Stripp, J. Whitsett, and R. A. Flavell. 1996. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA 93:7821-7825.
19. Ohmori, H., A. F. Dohrmann, M. Gallup, T. Tsuda, H. Kai, J. R. Gum, Jr., Y. S. Kim, and C. B. Basbaum. 1994. Molecular cloning of the amino-terminal region of a rat MUC-2 mucin gene homologue. J. Biol. Chem. 269: 17833-17840.
20. Shekels, L. L., C. Lyftogt, M. Kieliszewski, J. D. Filie, C. A. Kozak, and S. B. Ho. 1995. Mouse gastric mucin: cloning and chromosomal localization. Biochem. J. 311:775-785.
21. Gunning, P., P. Ponte, H. Okayama, J. Engel, H. Blau, and L. Kedes. 1983. Isolation and characterization of full-length cDNA clones for human α- and γ-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol. Cell. Biol. 3:787-795.
22. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72:248-254.
23. Pon, D. J., C. J. Van Staden, and I. W. Rodger. 1994. Hypertrophic and hyperplastic changes of mucus-secreting epithelial cells in rat airways: assessment using a novel, rapid, and simple technique. Am. J. Respir. Cell Mol. Biol. 10:625-634.
24. Plopper, C. G. 1983. Comparative morphologic features of bronchiolar epithelial cells: the clara cell. Am. Rev. Respir. Dis. 128:S37-S41.
25. Wood, K. A., E. Becker-Dunn, and K. Bottomly. 1985. Distinct functional phenotypes of cloned Ia-restricted helper T cells. J. Exp. Med. 162:188-201.
26. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T-cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
27. Wodnar-Filipowicz, A., C. Heusser, and C. Moroni. 1989. Production of the hematopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 339:150-157.
28. Plaut, M., J. H. Pierce, C. P. Watson, J. Hanley-Hyde, R. P. Nordan, and W. E. Paul. 1989. Mast cell lines produce lymphokines in response to cross linkage of FcERI or to calcium ionophores. Nature 339:64-67.
29. Ben-Sason, S. Z., G. Le Gros, D. H. Conrad, F. D. Finkelman, and W. E. Paul. 1989. Cross-linking Fc receptors stimulates splenic non-B, non-T cells to secrete interleukin-4 and other lymphokines. Proc. Natl. Acad. Sci. USA 98:1421-1425.
30. Seder, R. A., W. E. Paul, A. M. Dvorak, S. J. Sharkis, A. Kagey-Sobotka, Y. Niv, F. D. Finkelman, S. A. Barbieri, S. J. Galli, and M. Plaut. 1991. Mouse splenic and bone marrow cell populations that express high-affinity FcE receptors and produce interleukin-4 are highly enriched in basophils. Proc. Natl. Acad. Sci. USA 88:2835-2839.
31. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298-304.
32. Robinson, D. S., S. Ying, A. M. Bentley, O. Meng, J. North, S. R. Durham, A. B. Kay, and Q. Hamid. 1993. Relationships among numbers of bronchoalveolar lavage cells expressing mRNA for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J. Allergy Clin. Immunol. 92:397-403.
33. + T lymphocytes in atopic patients. J. Immunol. 144:4651-4656.
34. Parronchi, P., D. Macchia, M. P. Piccinni, C. Simonelli, E. Maggi, M. Ricci, A. A. Ansari, and S. Romagnani. 1991. Allergen and bacterial antigen specific T cell clones established from atopic donors show a differerent profile of cytokine production. Proc. Natl. Acad. Sci. USA 88:4538-4542.
35. Levine, S. J., P. Larivee, C. Logun, W. Angus, F. P. Ognibene, and J. H. Shelhamer. 1995. Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 12:192-204.
36. Ho, S. B., G. A. Niehans, C. Lyftogt, P.-S. Yan, D. L. Cherwitz, E. T. Gum, R. Dahiya, and Y. S. Kim. 1993. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res. 53:641-651.
37. Porchet, N., N. Van Cong, J. Dufosse, J. P. Audie, V. Guyonney-Duperate, M. S. Gross, C. Denis, P. Degand, A. Bernheim, and J. P. Aubert. 1991. Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Bochem. Biophys. Res. Commun. 175:414-422.
38. Toribara, N. W., A. M. Roberton, S. B. Ho, W.-L. Kuo, E. Gum, J. W. Hicks, J. R. Gum, J. C. Byrd, B. Siddiki, and Y. S. Kim. 1993. Human gastric mucin: identification of a unique species by expression cloning. J. Biol. Chem. 268:5879-5885.
39. Ho, S. B., A. M. Roberton, L. L. Shekels, C. T. Lyftogt, G. A. Niehans, and N. W. Toribara. 1995. Expression cloning of gastric mucin cDNA and localization of mucin gene expression. Gastroenterology 109:735-747.
40. Bobek, L. A., H. Tsai, A. R. Biesbrock, and M. J. Levine. 1993. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). J. Biol. Chem. 268: 20563-20569.
41. DiCosmo, B. F., G. P. Geba, D. Picarella, J. A. Elias, J. A. Rankin, B. R. Stripp, J. A. Whitsett, and R. A. Flavell. 1994. Airway epithelial cell expression of interleukin-6 in transgenic mice: uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest. 94:2028-2034.
42. Rankin, J. A., U.-A. Temann, B. Prasad, D. Picarella, A. Tarallo, B. DiCosmo, and R. A. Flavell. 1995. Overexpression of IL-5 in the lungs of transgenic mice. Am. J. Respir. Crit. Care Med. 151:827A. (Abstr.)
43. Donnelly, R., M. Fenton, J. Kaufman, J. Gerrad, and T. Gerrad. 1991. IL-1 expression in human monocytes is transcriptionally and post-transcriptionally regulated by IL-4. J. Immunol. 146:3431-3436.
44. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 stat. Science 265:1701-1706.