Drosophila single-minded represses gene transcription by activating the expression of repressive factors

Developmental Biology

Volumn 232, Issue 1, 2001, Pages 157-175

  Estes, Patricia ^a   Mosher, Jack ^a   Crews, Stephen T ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

bHLH PAS; CNS midline; Neuroectoderm; Single minded; Tango; Ventral nervous system defective

Indexed keywords

ARTICLE; BINDING SITE; DNA BINDING; DROSOPHILA; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSCRIPTION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; TRANSCRIPTION REGULATION;

DROSOPHILA;

EID: 0035313324     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0174     Document Type: Article

References (65)

1. PCR-ligation-PCR mutagenesis: A protocol for creating gene fusions and mutations
2. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
3. Molecular and genetic characterization of the Drosophila tartan gene
4. Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5
5. Single-minded and Down syndrome
6. Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis
7. Control of cell lineage-specific development and transcription by bHLH-PAS proteins
8. Remembrance of things PAS: Regulation of development by bHLH-PAS proteins
9. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product
10. Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development
11. msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm
12. Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: An animal model of Down's syndrome
13. Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis
14. The Spineless-Aristapedia and Tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila
15. Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS
16. Expression patterns of two murine homologs of Drosophila Single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
17. Transcriptional activation domains of the single-minded bHLH protein are required for CNS midline cell development
18. EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm
19. The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm
20. Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: Basis of binding specificity
21. Synergistic activation and repression of transcription by Drosophila homeobox proteins
22. dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo
23. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo
24. The midline glia of Drosophila: A molecular genetic model for the developmental functions of glia
25. vnd, a gene required for early neurogenesis of Drosophila, encodes a homeodomain protein
26. Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene
27. Specification of the Drosophila CNS midline cell lineage: Direct control of single-minded transcription by dorsal/ventral patterning genes
28. Influence of Drosophila ventral epidermal development by the CNS midline cells and spitz class genes
29. Drosophila NK-homeobox genes
30. Functional interactions between bHLH/PAS, Sox, and POU transcription factors regulate Drosophila CNS midline gene expression
31. Dorsoventral patterning in the Drosophila central nervous system: The vnd homeobox gene specifies ventral column identity
32. Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos
33. Single-minded - Two genes, three chromosomes
34. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
35. Different transcriptional properties of mSim-1 and mSim-2
36. The murine Sim-2 gene product inhibits transcription by active repression and functional interference
37. Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome
38. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells
39. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
40. Discrete enhancer elements mediate selective responsiveness of Enhancer of split complex genes to common transcription activators
41. Transcriptional regulation of breathless FGF receptor gene by binding of TRACHEALESS/dARNT heterodimers to three central midline elements in Drosophila developing trachea
42. The same dorsal binding site mediates both activation and repression in a context-dependent manner
43. Characterization and cloning of fasciclin III: A glycoprotein expressed on a subset of neurons and axon pathways in Drosophila
44. Two murine homologs of the Drosophila Single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein
45. MatInd and MatInspector - New fast and versatile tools for detection of consensus matches in nucleotide sequence data
46. Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog
47. Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator
48. Genetic transformation of Drosophila with transposable element vectors
49. Neuroblast pattern formation: Regulatory DNA that confers the vnd/NK-2 homeobox gene pattern on a reporter gene in transgenic lines of Drosophila
50. The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Amt and controls CNS midline and tracheal development
51. Molecular genetics of the single-minded locus: A gene involved in the development of the Drosophila nervous system
52. Vectors for Drosophila P-element-mediated transformation and tissue culture transfection
53. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
54. Convergence of Dorsal, Dpp, and Egfr signaling pathways subdivides the Drosophila neuroectoderm into three dorsal-ventral columns
55. Regulation of bHLH-PAS protein subcellular localization during Drosophila embryogenesis
56. Distinct expression patterns of different Enhancer of split bHLH genes during embryogenesis of Drosophila melanogaster
57. Dorsoventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity
58. CNS midline enhancers of the Drosophila slit and Toll genes
59. Control of CNS midline transcription by asymmetric E-box-like elements: Similarity to xenobiotic responsive regulation
60. GCG: The Wisconsin Package of sequence analysis programs
61. Alternate functions of the single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm
62. Interaction between the bHLH-PAS protein trachealess and the POU-domain protein drifter, specifies tracheal cell fates
63. The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins