EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm

Development

Volumn 122, Issue 11, 1996, Pages 3355-3362

  Gabay, Limor ^a   Scholz, Henrike ^b   Golembo, Myriam ^a   Klaes, Andrea ^b   Shilo, Ben Zion ^a   Klämbt, Christian ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cell fate; Drosophila; EGF receptor; Pointed; Spitz group; Ventral nervous system defective; Yan

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; DROSOPHILA; ECTODERM; EMBRYO; EMBRYO AXIS; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION;

ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ECTODERM; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; MORPHOGENESIS; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0029904093     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Beitel, G., Tuck, S., Greenwald, I. S. and Horvitz, R. H. (1996). The C. elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Genes Dev. 9, 3149-3162.
2. Bier, E., Jan, L. Y. and Jan, Y. N. (1990). rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev 4, 190-203.
3. Brunner, D., Ducker, K., Oellers. N., Hafen, E., Scholz, H. and Klämbt, C. (1994). The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370, 386-389.
4. Chang, Z., Price, B. D., Bockheim, S., Boedigheimer, M. J., Smith, R. and Laughon, A. (1993). Molecular and genetic characterization of the Drosophila tartan gene. Dev. Biol. 160, 315-332.
5. Diaz-Benjumea, F. J. and Hafen, E. (1994). The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120, 569-578.
6. Finkelstein, R., Smouse, D., Capaci, T. M., Spradling, A. C. and Perrimon, N. (1990). The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev. 4, 1516-1527.
7. Freeman, M., Klambt, C., Goodman, C. S. and Rubin, G. M. (1992). The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell 69, 963-975.
8. Golembo, M., Schweitzer, R., Freeman, M. and Shilo, B.-Z. (1996a). Argos transcription is induced by the Drosophila EGF receptor pathway, to form an inhibitory feedback loop. Development 122, 223-230.
9. Golembo, M., Raz, E. and Shilo, B. Z. (1996b). The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122, 3363-3370.
10. González-Reyes, A., Elliot, H. and St. Johnston, D. (1995). Polarization of both major body axes in Drosophila by gurken-torpedo signalling. Nature 375, 654-658.
11. Jiang, J. and Levine, M. (1993). Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell 72, 741-52.
12. Jimenez, F., Martin, M. L., Velasco, L., Chu, H., Sierra, J., Rosen, D. R. and White, K. (1995). vnd, a gene required for early neurogenesis of Drosophila. encodes a homeodomain protein. EMBO J. 14, 3487-3495.
13. Jürgens, G., Wieschaus, E., Nüsslein-Volhard, C. and Kluding, H. (1984) Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. II. Zygotic loci on the third chromosome. Roux's Arch. Dev. Biol. 193, 283-295.
14. Kim, S. H. and Crews, S. T. (1993). Influence of Drosophila ventral epidermal development by the CNS midline cells and spitz class genes. Development 118, 893-901.
15. Klaes, A., Menne, T., Stollewerk, A., Scholz, H. and Klämbt, C. (1994). The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS. Cell 78, 149-160.
16. Klämbt, C. (1993). The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117, 163-176.
17. Klämbt, C., Jacobs, J. R. and Goodman, C. S. (1991). The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance. Cell 64, 801-815.
18. Kolodkin, A. L., Pickup, A. T., Lin, D. M., Goodman, C. S. and Banerjee, U. (1994). Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila. Development 120, 1731-1745.
19. Lai, Z. C. and Rubin, G. M. (1992). Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70, 609-620.
20. Liaw, G.-J., Rudolph, K. M., Huang, J.-D., Dubnicoff, T., Courey, A. and Lengyel, J. A. (1995). The torso response element binds GAGA and NTF- 1/Elf-1, and regulates tailless by relief of repression. Genes Dev. 9, 3163-3176.
21. Margolis, J. and Spradling, A. (1995). Identification and behavior of epithelial stem cells in the Drosophila ovary. Development 121, 3797-3807.
22. Mayer, U. and Nüsslein-Volhard, C. (1988). A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev. 2, 1496-1511.
23. Mellerick, D. M. and Nirnberg, M. (1995). Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos. Dev. Biol. 171, 306-316.
24. Nüsslein-Volhard, C., Wieschaus, E. and Kluding, H. (1984). Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193, 267-282.
25. O'Neill, E. M., Rebay, I., Tjian, R. and Rubin, G. M. (1994). The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147.
26. Patel, N. H., Snow, P. M. and Goodman, C. S. (1987). Characterization and cloning of fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila. Cell 48, 975-988.
27. Raz, E. and Shilo, B. Z. (1992). Dissection of the faint little ball (flb) phenolype: determination of the development of the Drosophila central nervous system by early interactions in the ectoderm. Development 114, 113-123.
28. Raz, E. and Shila, B. Z. (1993). Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER. the EOF receptor homolog. Genes Dev. 7, 1937-1948.
29. Rebay, I. and Rubin, G. M. (1995). Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81, 857-866.
30. Rogge, R., Green, P. J., Urano, J., Horn-Saban, S., Mlodzik, M., Shilo, B.-Z., Hartenstein, V. and Banerjee, U. (1995). The role of van in mediating the choice between cell division and differentiation. Development 121, 3947-3958.
31. Roth, S., Neuman-Silberberg, F. S., Barcelo, G. and Schüpbach, T. (1995). cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. Cell 81, 967-978.
32. Rutledge, B. J., Zhang, K., Bier, E., Jan, Y. N. and Perrimon, N. (1992). The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev. 6, 1503-1517.
33. Scholz, H., Deatrick, J., Klaes, A. and Klämbt, C. (1993). Genetic dissection of pointed, a Drosophila gene encoding two ETS-related proteins. Genetics 135, 455-468.
34. Schweitzer, R., Howes, R., Smith, R., Shilo, B. Z. and Freeman, M. (1995a). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376, 699-702.
35. Schweitzer, R., Shaharabany, M., Seger, R. and Shilo, B. Z. (1995b). Secreted spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9, 1518-1529.
36. St Johnston, D. and Nüsslein-Volhard, C. (1992). The origin of pattern and polarity in the Drosophila embryo. Cell 68, 201-219.
37. Sturtevant, M. A., Roark, M. and Bier, E. (1993). The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev. 7, 961-973.
38. Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
39. Tei, H., Nihonmatsu, I., Yokokura, T., Ueda, R., Sano, Y., Okuda, T., Sato, K., Hirata, K., Fujita, S. C. and Yamamoto, D. (1992). pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor. Proc. Natl. Acad. Sci. USA 89, 6856-6860.
40. Wieschaus, E., Perrimon, N. and Finkelstein, R. (1992). orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila. Development 115, 801-811.
41. Wu, Y. and Han, M. (1994). Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes Dev. 8, 147-159.
42. Zak, N. B., Wides, R. J., Schejter, E. D., Raz, E. and Shilo, B. Z. (1990). Localization of the DER/flb protein in embryos: implications on the faint little ball lethal phenotype. Development 109, 865-874.
43. Zhang, K., Chaillet, J. R., Perkins, L. A., Halazonetis, T. D. and Perrimon, N. (1990). Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc. Natl. Acad. Sci. USA 87, 6281-6285.