Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS

Development

Volumn 127, Issue 21, 2000, Pages 4701-4709

  Epstein, D J ^a   Martinu, L ^a   Michaud, J L ^a   Losos, K M ^a   Fan, C M ^a   Joyner, A L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

BHLH PAS; Central nervous systems; Gene regulation; Mouse; Shh; Sim2

Indexed keywords

CIS ACTING ELEMENT; HELIX LOOP HELIX PROTEIN; MESSENGER RNA; REGULATOR PROTEIN; SONIC HEDGEHOG PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR POSTERIOR AXIS; ARTICLE; BRAIN REGION; CELL DIFFERENTIATION; CELL GROWTH; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DIENCEPHALON; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FOREBRAIN; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; MALE; MESENCEPHALON; MESODERM; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SECRETION; REGULATOR GENE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; TRANSGENE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BETA-GALACTOSIDASE; BODY PATTERNING; DIENCEPHALON; EMBRYONIC INDUCTION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEDGEHOG PROTEINS; HELIX-LOOP-HELIX MOTIFS; MESENCEPHALON; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROSENCEPHALON; PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; ERINACEIDAE; INVERTEBRATA; VERTEBRATA;

EID: 0033709839     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia
2. Comparison of early nerve cord development in insects and vertebrates
3. Ci: A complex transducer of the hedgehog signal
4. Characterization of npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system
5. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
6. Control of cell lineage-specific development and transcription by bHLH-PAS proteins
7. Remembrance of things PAS: Regulation of development by bHLH-PAS proteins
8. Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development
9. Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal plate
10. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development
11. Diminished Sonic Hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
12. Sonic hedgehog, a member of a family of putative signaling molecules is implicated in the regulation of CNS and limb polarity
13. Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS
14. Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis
15. Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
16. Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms
17. Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity
18. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
19. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome
20. Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube
21. A mouse model of greig cephalopolysyndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene
22. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- And mesoderm-derived tissues suggests multiple roles during postimplantation development
23. Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse
24. Overexpression of Id protein inhibits the muscle differentiation program: In vivo association of Id with E2A proteins
25. Influence of Drosophila ventral epidermal development by the CNS midline cells and spitz class genes
26. Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation
27. Requirement of 19K forms of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
28. Gli2 is required for induction of floor plate but not most ventral neurons in the mouse central nervous system
29. Production of targeted embryonic stem cell clones
30. Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
31. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
32. The murine Sim-2 gene product inhibits transcription by active repression and functional interference
33. Different transcriptional properties of mSim-1 and mSim-2
34. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells
35. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
36. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutatiion
37. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
38. Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein
39. Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)
40. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
41. Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
42. A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro
43. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination
44. The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo
45. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: Evidence for a transformation of the pallidum into the striatum
46. Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
47. The relationships between notochord and floor plate in vertebrate development revisited
48. Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)
49. Dorsoventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity
50. Control of CNS midline transcription by asymmetric E-box-like elements: Similarity to xenobiotic responsive regulation
51. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
52. Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
53. Slit branches out: A secreted protein mediates both attractive and repulsive axon guidance