Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus

Pharmaceutical Research

Volumn 13, Issue 4, 1996, Pages 523-527

  Ooie, Tsuyoshi ^a,b   Suzuki, Hiroshi ^a   Terasaki, Tetsuya ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anion transport system; Blood CSF barrier; Cerebrospinal fluid; Choroid plexus; Quinolone antibiotics

Indexed keywords

4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4 CHLOROMERCURIBENZOIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CHLOROMERCURIBENZENESULFONIC ACID; FLEROXACIN; OUABAIN; PENICILLIN G; PROBENECID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ROTENONE;

ACTIVE TRANSPORT; ANIMAL TISSUE; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CEREBROSPINAL FLUID; CHOROID PLEXUS; COMPETITIVE INHIBITION; DRUG ACCUMULATION; DRUG TRANSPORT; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; 4-ACETAMIDO-4'-ISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID; 4-CHLOROMERCURIBENZENESULFONATE; ANIMALS; ANTI-INFECTIVE AGENTS; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT, ACTIVE; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CHOROID PLEXUS; ENZYME INHIBITORS; FLEROXACIN; ION TRANSPORT; ISOTOPE LABELING; MALE; OUABAIN; PENICILLIN G; PENICILLINS; PROBENECID; RATS; RATS, WISTAR; RENAL AGENTS; ROTENONE; SULFHYDRYL REAGENTS; UNCOUPLING AGENTS;

EID: 0029922224     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016081618149     Document Type: Article

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