Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 1, 1999, Pages 51-57

  Murata, Mitsuo ^a,b   Tamai, Ikumi ^a,c   Kato, Hiroshi ^a   Nagata, Osamu ^b   Kato, Hideo ^b   Tsuji, Akira ^a,c  

^a KANAZAWA UNIVERSITY   (Japan)

^b Abbott Japan Co Ltd   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; 4 ACETAMIDO 4' ISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 4 AMINOHIPPURIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 AMINO 7 (7 AMINO 5 AZASPIRO[2.4]HEPT 5 YL) 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHYL 4 OXO 3 QUINOLINECARBOXYLIC ACID; CYCLOSPORIN A; ENOXACIN; GLYCOPROTEIN P; GREPAFLOXACIN; LACTIC ACID; LEVOFLOXACIN; LOMEFLOXACIN; NALIDIXIC ACID; NICOTINIC ACID; NORFLOXACIN; OFLOXACIN; PROBENECID; QUINIDINE; SPARFLOXACIN; TETRYLAMMONIUM; TOSUFLOXACIN; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; TISSUE DISTRIBUTION;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMALS; ANTI-INFECTIVE AGENTS; BICARBONATES; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARIES; CATTLE; CELLS, CULTURED; DRUG RESISTANCE, MULTIPLE; ENDOTHELIUM, VASCULAR; FLUOROQUINOLONES; HUMANS; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; PERMEABILITY; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 0032968064     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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