DNA damage: Chk1 and Cdc25, more than meets the eye

Current Opinion in Genetics and Development

Volumn 11, Issue 1, 2001, Pages 78-82

  Walworth, N C ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE; PROTEIN CDC25; TYROSINE; UNCLASSIFIED DRUG;

CELL ACTIVITY; CELL CYCLE; CELL SURVIVAL; DNA DAMAGE; ENZYME ACTIVITY; EUKARYOTIC CELL; HUMAN; MITOSIS RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW;

EUKARYOTA;

EID: 0035253624     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00160-X     Document Type: Review

References (47)

1. Universal control mechanism regulating the onset of M-phase
2. Cyclin-dependent kinases: Engines, clocks, and microprocessors
3. cdc25+ functions as an inducer in the mitotic control of fission yeast
4. p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast
5. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
6. Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells
7. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
8. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
9. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
10. Sensing and responding to DNA damage
11. The G2-phase DNA-damage checkpoint
12. Characterization of Schizosaccharomyces pombe Hus1: A PCNA-related protein that associates with Rad1 and Rad9
13. A novel Rad24 checkpoint complex closely related to replication factor C
14. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
15. Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: A gene required for the DNA damage checkpoint but not the replication checkpoint
16. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
17. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint
18. Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage
19. 14-3-3 Protein homologs required for the DNA damage checkpoint in fission yeast
20. A kinase from fission yeast responsible for blocking mitosis in S phase
21. Meiotic DNA replication checkpoint control in fission yeast
22. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
23. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
24. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts
25. The Xenopus chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
26. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
27. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding
28. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
29. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
30. Maintenance of G2 arrest in the Xenopus oocyte: A role for 14-3-3-mediated inhibition of Cdc25 nuclear import
31. Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
32. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
33. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
34. Substrate specificity determinants of the checkpoint kinase Chk1
35. DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe
36. Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint
37. The G2 DNA damage checkpoint targets both Wee1 and Cdc25
38. Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis
39. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
40. Chromosome cohesion, condensation and separation
41. Polo-like kinase-1 is a target of the DNA damage checkpoint
42. Rapid destruction of human Cdc25A in response to DNA damage
43. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis
44. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase
45. Schizosaccharomyces pombe Hsk1p is a potential Cds1p target required for genome integrity
46. Activation of the DNA replication checkpoint through RNA synthesis by primase
47. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus eg extracts