메뉴 건너뛰기




Volumn 2, Issue 1, 1999, Pages 33-41

Variability in drug response as a factor in drug design

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMLODIPINE; ATENOLOL; AZITHROMYCIN; BENZTHIAZIDE; BETA 2 ADRENERGIC RECEPTOR; BETAXOLOL; CLOZAPINE; CYTOCHROME P450; DANAZOL; DIAZEPAM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ERYTHROMYCIN; FLUCONAZOLE; GRISEOFULVIN; HALOFANTRINE; KETOCONAZOLE; MEPHENYTOIN; METOPROLOL; NADOLOL; NIFEDIPINE; NITROFURANTOIN; OMEPRAZOLE; PHENYTOIN; PIRENZEPINE; RANITIDINE; SALBUTAMOL; SALMETEROL; TELENZEPINE; WARFARIN;

EID: 0032900660     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (32)
  • 1
    • 0027984902 scopus 로고
    • Role of patient compliance in clinical pharmacokinetics
    • Urquhart J: Role of patient compliance in clinical pharmacokinetics. Clin Pharmacokin (1994) 27:202-215.
    • (1994) Clin Pharmacokin , vol.27 , pp. 202-215
    • Urquhart, J.1
  • 2
    • 33749710264 scopus 로고    scopus 로고
    • This paper introduces the concept of forgiveness' as an important parameter when considering variability in drug response.
    • This paper introduces the concept of forgiveness' as an important parameter when considering variability in drug response.
  • 3
    • 0342468147 scopus 로고    scopus 로고
    • Characterization and bioavallabllity of danazol-hydroxypropyl β-cyclodextrin coprecipitates
    • Ghorab MM, Adeyeye CM
    • Badawy SIF, Ghorab MM, Adeyeye CM: Characterization and bioavallabllity of danazol-hydroxypropyl β-cyclodextrin coprecipitates. IntJPharm (1996) 128:45-54.
    • (1996) IntJPharm , vol.128 , pp. 45-54
    • Badawy, S.I.F.1
  • 4
    • 0022402243 scopus 로고
    • Sugimoto I: Physical properties of solid dispersions of poorly watersoluble drugs with enteric coating agents
    • Kawamura R, Nakagawa H.
    • Hasegawa A, Kawamura R, Nakagawa H. Sugimoto I: Physical properties of solid dispersions of poorly watersoluble drugs with enteric coating agents. Chem Pharm Bull (1985) 33:3429-3435.
    • (1985) Chem Pharm Bull , vol.33 , pp. 3429-3435
    • Hasegawa, A.1
  • 5
    • 0029996464 scopus 로고    scopus 로고
    • A physicochemical basis for the effect of food on the absolute oral bioavailability of Halofantrine
    • Porter CJH, Charman WN
    • Humberstone AJ, Porter CJH, Charman WN: A physicochemical basis for the effect of food on the absolute oral bioavailability of Halofantrine. J Pharm Sci (1996)85:525-529.
    • (1996) J Pharm Sci , vol.85 , pp. 525-529
    • Humberstone, A.J.1
  • 6
    • 0022548510 scopus 로고
    • Slaughter RL: Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as tablet and solution to humans and dogs
    • Brass C, Schentag JJ.
    • Baxter JG, Brass C, Schentag JJ. Slaughter RL: Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as tablet and solution to humans and dogs. J Pharm Sc/(1986) 75:443-447.
    • (1986) J Pharm Sc/ , vol.75 , pp. 443-447
    • Baxter, J.G.1
  • 7
    • 0017108613 scopus 로고
    • Biopharmaceutical aspects of the absorption of orally administered nitrofurantoin
    • Tramp TFJ, Huizinga T
    • Moolenaar F, Tramp TFJ, Huizinga T: Biopharmaceutical aspects of the absorption of orally administered nitrofurantoin. Pharm Weekbl (1975) 111:1253-1264.
    • (1975) Pharm Weekbl , vol.111 , pp. 1253-1264
    • Moolenaar, F.1
  • 8
    • 0021185679 scopus 로고
    • Phenytoin prodrugs III: Water-soluble prodrugs for oral and/or parenteral use
    • Schuller S, Sloan KB, Stella VJ
    • Varia SA, Schuller S, Sloan KB, Stella VJ: Phenytoin prodrugs III: Water-soluble prodrugs for oral and/or parenteral use. J Pharm Sei (1984) 73:1068-1073.
    • (1984) J Pharm Sei , vol.73 , pp. 1068-1073
    • Varia, S.A.1
  • 9
    • 0028269813 scopus 로고
    • The application of solid dispersion technique with D-mannitol to the improvement in oral absorption of triamterene
    • Gines JM, Moyano JR, Rabasco AM
    • Arias MJ, Gines JM, Moyano JR, Rabasco AM: The application of solid dispersion technique with D-mannitol to the improvement in oral absorption of triamterene. J Drug Target (1994) 2:45-51.
    • (1994) J Drug Target , vol.2 , pp. 45-51
    • Arias, M.J.1
  • 10
    • 0031958251 scopus 로고    scopus 로고
    • Warhurst G, Gitford J, Walker D, Ayrton J, Eastmond R, Rowland M: Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides
    • Murby S.
    • He YL, Murby S. Warhurst G, Gitford J, Walker D, Ayrton J, Eastmond R, Rowland M: Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides. J Pharm Sei (1998) 87:626-633.
    • (1998) J Pharm Sei , vol.87 , pp. 626-633
    • He, Y.L.1
  • 11
    • 77953314801 scopus 로고    scopus 로고
    • Physiology of the gastrointestinal tract in relation to drug absorption
    • Smith SE: Physiology of the gastrointestinal tract in relation to drug absorption. Int Pharm J (I987) 1:101-104.
    • Int Pharm J I , vol.987 , pp. 101-104
    • Smith, S.E.1
  • 12
    • 0018725622 scopus 로고
    • Food-induced reduction in bioavaiiability of atenolol
    • Stenberg P, Uedholm H, Schersten B, WaahlinBoll E
    • Melander A, Stenberg P, Uedholm H, Schersten B, WaahlinBoll E: Food-induced reduction in bioavaiiability of atenolol. Eur J ClinPharmacol(1979) 16:327-330.
    • (1979) Eur J ClinPharmacol , vol.16 , pp. 327-330
    • Melander, A.1
  • 13
    • 0029865450 scopus 로고    scopus 로고
    • Design of drugs involving the concepts of theories of drug metabolism and pharmacokinetics
    • Jones BC, Walker DK
    • Smith, DA, Jones BC, Walker DK: Design of drugs involving the concepts of theories of drug metabolism and pharmacokinetics. Med Res Rev (1996) 16:243-266.
    • (1996) Med Res Rev , vol.16 , pp. 243-266
    • Smith, D.A.1
  • 14
    • 33749807331 scopus 로고    scopus 로고
    • This paper covers, in some depth, many of the concepts referred to in this review.
    • This paper covers, in some depth, many of the concepts referred to in this review.
  • 16
    • 33749700416 scopus 로고    scopus 로고
    • UK-84,149: A novel gut-selective spasmolytic with calcium antagonist activity
    • Alker D, Surges RA, Cross PE, Greengrass PM, Mclntyre P, Quinn P
    • Wallis RM, Alker D, Surges RA, Cross PE, Greengrass PM, Mclntyre P, Quinn P: UK-84,149: a novel gut-selective spasmolytic with calcium antagonist activity. Br J Pharmacol (I994) 112:574P.
    • Br J Pharmacol (I994) , vol.112
    • Wallis, R.M.1
  • 17
    • 0026459382 scopus 로고
    • Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes
    • Smith DA, Jones BC: Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes. Biochem Pharmacol (1992) 44:2089-2098.
    • (1992) Biochem Pharmacol , vol.44 , pp. 2089-2098
    • Smith, D.A.1    Jones, B.C.2
  • 18
    • 33749754448 scopus 로고    scopus 로고
    • This paper is a pivotal reference in the understanding of cytocnrome P450 substrate specificities.
    • This paper is a pivotal reference in the understanding of cytocnrome P450 substrate specificities.
  • 19
    • 0032444641 scopus 로고    scopus 로고
    • Human cytochrome P450s: Selectivity and measurement in vivo
    • Able SM, Hyland R, Jones BC: in press.
    • Smith DA, Able SM, Hyland R, Jones BC: Human cytochrome P450s: Selectivity and measurement in vivo. Xenobiotica (1998) in press.
    • (1998) Xenobiotica
    • Smith, D.A.1
  • 20
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners JO, Birkett DJ: Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J din Pharmacol(1998) 45:525-538.
    • (1998) Br J Din Pharmacol , vol.45 , pp. 525-538
    • Miners, J.O.1    Birkett, D.J.2
  • 21
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • Kaminsky LS, Zhang ZY: Human P450 metabolism of warfarin. Pharmacol Trier (1997) 73:67-74.
    • (1997) Pharmacol Trier , vol.73 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.Y.2
  • 22
    • 0025032064 scopus 로고
    • Single- Vs multiple-dose pharmacokinetics of clozapine in psychiatric patients
    • Hsuan F, Honigfeld G, Robinson WT, Ereshelsky L, Crismon ML, Salelad SR, Hirschavitz J, Wagner R
    • Choc MG, Hsuan F, Honigfeld G, Robinson WT, Ereshelsky L, Crismon ML, Salelad SR, Hirschavitz J, Wagner R: Single- vs multiple-dose pharmacokinetics of clozapine in psychiatric patients. Pharm Res (1990) 7:347-351.
    • (1990) Pharm Res , vol.7 , pp. 347-351
    • Choc, M.G.1
  • 23
    • 0030868485 scopus 로고    scopus 로고
    • Genetic association between sensitivity to warfarin and expression of CYP2C9*3
    • Haining RL, Henné KR, Davis G, Rushmore TH, Trager WF, Rettie AE
    • Steward DJ, Haining RL, Henné KR, Davis G, Rushmore TH, Trager WF, Rettie AE: Genetic association between sensitivity to warfarin and expression of CYP2C9*3. Pharmacogenetics (1997) 7:361-367.
    • (1997) Pharmacogenetics , vol.7 , pp. 361-367
    • Steward, D.J.1
  • 24
    • 0030721713 scopus 로고    scopus 로고
    • Population pharmacokinetics of clozapine evaluated with the nonparametric maximum likelihood method
    • Merle Y, Mentré F, Mallet A
    • Jerting M, Merle Y, Mentré F, Mallet A: Population pharmacokinetics of clozapine evaluated with the nonparametric maximum likelihood method. Br J Clin Pharmacol (1997) 44:447-453.
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 447-453
    • Jerting, M.1
  • 25
    • 0030656425 scopus 로고    scopus 로고
    • The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine
    • Engel G, Johansson l, Zanger UM, Bertilsson L
    • Eiermann B, Engel G, Johansson l, Zanger UM, Bertilsson L: The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. Br J Clin Pharmacol (1997) 44:439-446.
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 439-446
    • Eiermann, B.1
  • 27
    • 33749748742 scopus 로고    scopus 로고
    • This paper emphasizes the reasons for variability in drug performance.
    • This paper emphasizes the reasons for variability in drug performance.
  • 28
    • 0031596301 scopus 로고    scopus 로고
    • 2c. receptor polymorphisms and psychopathology in late onset Alzheimer's disease
    • Arranz MJ, Powell JF, Collier DA, Lovestone S
    • 2c. receptor polymorphisms and psychopathology in late onset Alzheimer's disease. Hum Mol Genet (1998) 7:1507-1509.
    • (1998) Hum Mol Genet , vol.7 , pp. 1507-1509
    • Holmes, C.1
  • 29
    • 0031466866 scopus 로고    scopus 로고
    • Association between genetic polymorphisms of the 2adrenoceptor and response to albuterol in children with and without a history of wheezing
    • Graves PE, Baldini M, Solomon S, Erickson R
    • Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R: Association between genetic polymorphisms of the 2adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest (1997) 100:3184-3188.
    • (1997) J Clin Invest , vol.100 , pp. 3184-3188
    • Martinez, F.D.1
  • 30
    • 0029841642 scopus 로고    scopus 로고
    • Sustained activation of a G protein-coupled receptor via 'anchored' agonist binding
    • Spasoff AP, Coleman RA, Johnson M, Liggett SB
    • Green SA, Spasoff AP, Coleman RA, Johnson M, Liggett SB: Sustained activation of a G protein-coupled receptor via 'anchored' agonist binding. Molecular localization of the salmeterol exosite within the ,-adrenergic receptor. J Biol Chem (1996) 271:24029-24035.
    • (1996) Molecular Localization of the Salmeterol Exosite Within the ,-adrenergic Receptor. J Biol Chem , vol.271 , pp. 24029-24035
    • Green, S.A.1
  • 31
    • 0023818954 scopus 로고
    • 2H] telenzepine to muscarinic acetylcholine receptors in calf forebrain
    • Auriga C, Kinder B, Birdsall NJM
    • 2H] telenzepine to muscarinic acetylcholine receptors in calf forebrain. Eur J Pharmacol (1988) 145:87-90.
    • (1988) Eur J Pharmacol , vol.145 , pp. 87-90
    • Schudt, C.1
  • 32
    • 0026590432 scopus 로고
    • Quantification of metoprolol beta2-adrenoceptor antagonism in asthmatic patients by pharmacokinetic-pharmacodynamlc modeling
    • Jonkers RE, van Boxtel CJ
    • Braat MCP, Jonkers RE, van Boxtel CJ: Quantification of metoprolol beta2-adrenoceptor antagonism in asthmatic patients by pharmacokinetic-pharmacodynamlc modeling. Pulm Pharmacol (1992) 5:31-38.
    • (1992) Pulm Pharmacol , vol.5 , pp. 31-38
    • Braat, M.C.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.