Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: Implication in drug-induced ceramide generation and apoptosis

Molecular Pharmacology

Volumn 55, Issue 1, 1999, Pages 118-125

  Bettaïeb, Ali ^a   Plo, Isabelle ^a   Mansat De Mas, Véronique ^a   Quillet Mary, Anne ^a   Levade, Thierry ^b   Laurent, Guy ^a,c   Jaffrézou, Jean Pierre ^a  

^a INSTITUT CLAUDIUS REGAUD   (France)

^b CHU RANGUEIL   (France)

^c CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DAUNORUBICIN; DIACYLGLYCEROL; MITOXANTRONE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE C; PHOSPHORYLCHOLINE; PROTEIN KINASE C; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYDROLYSIS; LEUKEMIA CELL; LIPOGENESIS; PRIORITY JOURNAL;

EID: 0038027936     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.1.118     Document Type: Article

References (47)

1. Allouche M, Bettaïeb A, Vindis C, Rousse A, Grigon C and Laurent G (1997) Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells. Oncogene 14:1837-1845.
2. Andrieu N, Salvayre R and Levade T (1994) Evidence against the environnement of the acid lysosomal sphingomyelinase in tumor necrosis factor-and interleukin-1 induced sphingomyelin cycle and cell proliferation in human fibroblasts. Biochem J 303:341-345.
3. Augé N, Andrieu N, Nègre-Salvayre A, Thiers JC, Levade T and Salvayre R (1996) The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. J Biol Chem 271:19251-19255.
4. Avila MA, Otero G, Cansado J, Dritschilo A, Velasco JA and Notario V (1993) Activation of phospholipase D participates in signal transduction pathways responsive to gamma-radiation. Cancer Res 53:4474-4476.
5. Bailly JD, Skladanowski A, Bettaïeb A, Mansat V, Larsen A and Laurent G (1997) Natural resistance of acute myeloid leukemia cells lines to mitoxantrone is associated with lack of apoptosis. Leukemia 11:1523-1532.
6. Bettaïeb A, Record M, Côme MG, Bras AC, Chap H, Laurent G and Jaffrézou JP (1996) Opposite effects of TNFα on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: Role of transverse sphingomyelin distribution in the plasma membrane. Blood 88:1465-1472.
7. Bezombes C, Maestre N, Laurent G, Levade T, Bettaïeb A and Jaffrézou JP (1998) Restoration of TNFα-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833. FASEB J 12:101-109.
8. Bishop WR, Ganong BR and Bell RM (1986) Attenuation of sn-1,2-diacylglycerol second messenger. Metabolism of exogenous diacylglycerols by human platelets. J Biol Chem 261:6993-7000.
9. Chabner BA and Myer CE (1989) Clinical pharmacology of cancer chemotherapy in Cancer: Principles and Practice of Oncology (DeVitta VTJ, Hellman S and Rosenberg SA eds) pp 349-395, JB Lippencott Company, Philadelphia, PA.
10. Chen SJ, Klann E, Gower MC, Powell CM, Sessoms JS and Sweatt JD (1993) Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C. Biochem 32:1032-1039.
11. Chmura SJ, Nodzenski E, Weichselbaum RR and Quintans J (1996) Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase. Cancer Res 56:2711-2714.
12. Chung T, Crilly KS, Anderson WH, Mukherjee JJ and Kiss Z (1997) ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3′-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate. J Biol Chem 272:3064-3072.
13. Dbaibo G, Perry DK, Gamard CJ, Platt R, Poirier GG, Obeid LM and Hannun (1997) YA Cytokine response modifier A (crmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med 185:481-490.
14. de Chaffoy de Courcelles D, Roevens P, Van Belle H, Kennis L, Somers Y and De Clerk F (1989) The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949. J Biol Chem 264:3274-3285.
15. Folch J, Lees M and Sloane-Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509.
16. Garcia-Ruiz C, Colell A, Mari M, Morales A and Fernandez-Checa JC (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem 272:11369-11377.
17. Haimovitz-Friedmann A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z and Kolesnick RN (1994) Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 180:525-535.
18. Hannun YA (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274:1855-1861.
19. Hannun YA (1997) Apoptosis and the dilemma of cancer chemotherapy. Blood 89:1845-1853.
20. Hannun YA and Bell RM (1989) Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243:500-507.
21. Hannun YA and Obeid LM (1995) Ceramide: An intracellular signal for apoptosis. Trends Biol Sci 20:73-77.
22. Jaffrézou JP, Levade T, Bettaïeb A, Andrieu N, Bezombes C, Maestre N, Vermeersch S, Rousse A and Laurent G (1996) Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis, EMBO J 15:2417-2424.
23. Jarvis WD, Fornari FA, Traylor RS, Martin HA, Kramer LB, Erukulla RK, Bittman R and Grant S (1996) Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J Biol Chem 271:8275-8284.
24. Jarvis WD, Turner AJ, Povirk LF, Traylor RS and Grant S (1994a) Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54:1707-1714.
25. Jarvis WDJ, Fornari FA, Browning JL, Gewirtz DA, Kolesnick RN and Grant SG (1994b) Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J Biol Chem 269:31685-31692.
26. Kolesnick R and Fuks Z (1995) Ceramide: A signal for apoptosis or mitogenesis? J Exp Med 181:1949-1952.
27. Kumar S (1995) ICE-like proteases in apoptosis. Trends Biol Sci 20:198-203.
28. Lacal JC, Moscat J and Aaronson SA (1987) Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature 330:269-272.
29. Levade T, Tempesta MC and Salvayre R (1993) The in situ degradation of ceramide, a potential lipid mediator, is not completely impaired in Farber disease. FEBS Lett 329:306-312.
30. Mansat V, Bettaïeb A, Levade T, Laurent G and Jaffrézou JP (1997a) Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. FASEB J 11:695-702.
31. Mansat V, Laurent G, Levade T. Bettaïeb A and Jaffrézou JP (1997b) The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. Cancer Res 57:5300-5304.
32. Müller-Decker K (1989) Interruption of TPA-induced signals by an antiviral and antitumoral xanthate compound: Inhibition of a phospholipase C-type reaction. Biochem Biophys Res Commun 162:198-205.
33. Nishio K, Sugimoto Y, Fujiwara Y, Ohmori T, Morikage T, Takeda Y and N Saijo (1992) Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum (II). J Clin Invest 89:1622-1628.
34. Pörn-Ares MI, Chow SC, Slotte JP and Orrenius S (1997) Induction of apoptosis and potentiation of TNF-and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. Exp Cell Res 235:48-54.
35. Posada J, Vichi P and Tritton TR (1989) Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells. Cancer Res 49:6634-6639.
36. Quillet-Mary A. Jaffrézou JP, Mansat V, Bordier C and Laurent G (1997) Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J Biol Chem 272:21388-21395.
37. Quillet-Mary A, Mansat V, Duchayne E, Côme MG, Allouche M, Bailly JD, Bordier C and Laurent G (1996) Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines. Leukemia 10:417-425.
38. Rao P and Mufson RA (1994) Human interleukin-3 stimulates a phosphatidylcholine specific phospholipase C and protein kinase C translocation. Cancer Res 54:777-781.
39. Rao P and Mufson RA (1995) Human IL-3 receptor signaling: Rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells. J Immunol 154:1664-1670.
40. Rubin E, Kharbanda S, Gunji H, Weichselbaum R and Kufe D (1992) cis-Diamminedichloroplatinum (II) induces c-jun expression in human myeloid leukemia cells: Potential involvement of a protein kinase C-independent signaling pathway. Cancer Res 52:878-882.
41. Schütze S, Berkovic D, Tomsing O, Unger C and Kronke M (1991) Tumor necrosis factor induces rapid production of 1′2′ diacylglycerol by a phosphatidylcholine-specific phospholipase C. J Exp Med 174:975-988.
42. Schütze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K and Krönke M (1992) TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71:765-776.
43. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85.
44. Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA and Obeid LM (1996) prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J 315:25-28.
45. Strum JC, Small GW, Pauig SB and Daniels LW (1994) 1-b-d-arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. J Biol Chem 269:15493-15497.
46. Uckun FM, Schieven GL, Tuel-Ahlgren LM, Dibirdik I, Myers DE, Ledbetter JA and Song CW (1993) Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors. Proc Natl Acad Sci USA 90:252-256.
47. Van Veldhoven PP, Matthews JJ, Bolognesi DP and Bell RM (1992) Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells. Biochem Biophys Res Commun 187:209-216.