메뉴 건너뛰기




Volumn 13, Issue 12, 1999, Pages 1501-1510

L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: Role of inhibition of ceramide generation

Author keywords

Cardiotoxicity; Oxidative stress; Staurosporine; Tumor necrosis factor

Indexed keywords

ANTHRACYCLINE; CARNITINE; CERAMIDE; DOXORUBICIN; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 0345713153     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.12.1501     Document Type: Article
Times cited : (166)

References (66)
  • 1
    • 0022965207 scopus 로고
    • Prospective study of cardiomyopathy induced by adjuvant doxorubicin therapy in patients with soft-tissue sarcomas
    • Ettinghausen, S. E., Bonow, R. O., Palmeri, S. T., Seipp, C. A., Steinberg, S. M., White, D. E., and Rosenberg, S. A. (1986) Prospective study of cardiomyopathy induced by adjuvant doxorubicin therapy in patients with soft-tissue sarcomas. Arch. Surg. 121, 1445-1451
    • (1986) Arch. Surg. , vol.121 , pp. 1445-1451
    • Ettinghausen, S.E.1    Bonow, R.O.2    Palmeri, S.T.3    Seipp, C.A.4    Steinberg, S.M.5    White, D.E.6    Rosenberg, S.A.7
  • 2
    • 0022461554 scopus 로고
    • The impact of induction anthracycline on long-term failure-free survival in childhood acute lymphoblastic leukemia
    • Hitchcock-Bryan, S., Gelber, R. D., Cassady, J. R., and Sallan S. E. (1986) The impact of induction anthracycline on long-term failure-free survival in childhood acute lymphoblastic leukemia. Med. Pediatr. Oncol. 14, 211-215
    • (1986) Med. Pediatr. Oncol. , vol.14 , pp. 211-215
    • Hitchcock-Bryan, S.1    Gelber, R.D.2    Cassady, J.R.3    Sallan, S.E.4
  • 3
    • 0030317942 scopus 로고    scopus 로고
    • Anthracycline-induced cardiotoxicity
    • Shan, K, Lincoff, M., and Young, J. B. (1996) Anthracycline-induced cardiotoxicity. Ann. Intern. Med. 125, 47-58
    • (1996) Ann. Intern. Med. , vol.125 , pp. 47-58
    • Shan, K.1    Lincoff, M.2    Young, J.B.3
  • 4
    • 0017656527 scopus 로고
    • Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response
    • Myers, C. E., McGuire, W. P., Liss, R. H., Ifrim, I., Grotzinger, K., and Young, R. C. (1977) Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response. Science 197, 165-167
    • (1977) Science , vol.197 , pp. 165-167
    • Myers, C.E.1    McGuire, W.P.2    Liss, R.H.3    Ifrim, I.4    Grotzinger, K.5    Young, R.C.6
  • 5
    • 0025051505 scopus 로고
    • Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses
    • Olson, R. D., and Mushlin, P. S. (1990) Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J. 4, 3076-3086
    • (1990) FASEB J. , vol.4 , pp. 3076-3086
    • Olson, R.D.1    Mushlin, P.S.2
  • 6
    • 0016270576 scopus 로고
    • Electrolyte and morphologic alteration of myocardium in adriamycin-treated rabbits
    • Olson, H. M., Young, D. M., Prieur, D. J., LeRoy, A. F., and Reagan, R. L. (1974) Electrolyte and morphologic alteration of myocardium in adriamycin-treated rabbits. Am. J. Pathol. 77, 439-454
    • (1974) Am. J. Pathol. , vol.77 , pp. 439-454
    • Olson, H.M.1    Young, D.M.2    Prieur, D.J.3    LeRoy, A.F.4    Reagan, R.L.5
  • 7
    • 0016835084 scopus 로고
    • Alterations in DNA synthesis in cardiac tissue induced by adriamycin in vivo. Relationship to fatal toxicity
    • Rosenoff, S. H., Brooks, E., Bostick, F., and Young, R. E. (1975) Alterations in DNA synthesis in cardiac tissue induced by adriamycin in vivo. Relationship to fatal toxicity. Biochem. Pharmacol. 24, 1898-1901
    • (1975) Biochem. Pharmacol. , vol.24 , pp. 1898-1901
    • Rosenoff, S.H.1    Brooks, E.2    Bostick, F.3    Young, R.E.4
  • 8
    • 0000705619 scopus 로고    scopus 로고
    • Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion
    • Umansky, S. R., Shapiro, J. P., Cuenco, G. M., Foehr, M. W., Bathurst, I. C., Tomei, L. D. (1997) Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion. Cell Death Differ. 4, 608-616
    • (1997) Cell Death Differ. , vol.4 , pp. 608-616
    • Umansky, S.R.1    Shapiro, J.P.2    Cuenco, G.M.3    Foehr, M.W.4    Bathurst, I.C.5    Tomei, L.D.6
  • 9
    • 0032494175 scopus 로고    scopus 로고
    • Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I
    • Wang, L., Ma, W., Markovich, R., Chen, J-W., and Wang, P. H. (1998) Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I. Circ. Res. 83, 516-522
    • (1998) Circ. Res. , vol.83 , pp. 516-522
    • Wang, L.1    Ma, W.2    Markovich, R.3    Chen, J.-W.4    Wang, P.H.5
  • 13
    • 0021024932 scopus 로고
    • Carnitine metabolism and functions
    • Bremer, J. (1983) Carnitine metabolism and functions. Physiol. Rev. 63, 1420-1480
    • (1983) Physiol. Rev. , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 14
    • 0027288347 scopus 로고
    • Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: Inhibition by L-acetylcarnitine
    • Galli, G., and Fratelli, M. (1993) Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: inhibition by L-acetylcarnitine. Exp. Cell Res. 204, 54-60
    • (1993) Exp. Cell Res. , vol.204 , pp. 54-60
    • Galli, G.1    Fratelli, M.2
  • 15
    • 0028609205 scopus 로고
    • L-carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation
    • Revoltella, R. P., Dal Canto, B., Caracciolo, L., and D'Urso, C. M. (1994) L-carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation. Biochim. Biophys. Acta 1224, 333-341
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 333-341
    • Revoltella, R.P.1    Dal Canto, B.2    Caracciolo, L.3    D'Urso, C.M.4
  • 16
    • 0030948224 scopus 로고    scopus 로고
    • Influence of L-carnitine on CD95 cross-linking-induced apoptosis and ceramide generation in human cell lines: Correlation with its effects on purified acidic and neutral sphingomy-elinases in vitro
    • Di Marzio, L., Alesse, E., Roncaioli, P., Muzi, P., Moretti, S., Marcellini, S., Amicosante, G., De Simone, C., and Cifone, M. G. (1997) Influence of L-carnitine on CD95 cross-linking-induced apoptosis and ceramide generation in human cell lines: correlation with its effects on purified acidic and neutral sphingomy-elinases in vitro. Proc. Assoc. Am. Physicians 109, 154-163
    • (1997) Proc. Assoc. Am. Physicians , vol.109 , pp. 154-163
    • Di Marzio, L.1    Alesse, E.2    Roncaioli, P.3    Muzi, P.4    Moretti, S.5    Marcellini, S.6    Amicosante, G.7    De Simone, C.8    Cifone, M.G.9
  • 17
    • 0022624211 scopus 로고
    • Carnitine protection against adriamycin-induced cardiomyopathy in rats
    • McFalls, E. O., Paulson, D. J., Gilbert, E. F., and Shug, A. L. (1986) Carnitine protection against adriamycin-induced cardiomyopathy in rats. Life Sci. 38, 497-505
    • (1986) Life Sci. , vol.38 , pp. 497-505
    • McFalls, E.O.1    Paulson, D.J.2    Gilbert, E.F.3    Shug, A.L.4
  • 18
    • 0030346365 scopus 로고    scopus 로고
    • Long-term 1-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure
    • Kawasaki, N., Lee, J. D., Shimizu, H., and Ueda, T. (1996) Long-term 1-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure. J. Cardiac Failure 2, 293-299
    • (1996) J. Cardiac Failure , vol.2 , pp. 293-299
    • Kawasaki, N.1    Lee, J.D.2    Shimizu, H.3    Ueda, T.4
  • 19
    • 0019452532 scopus 로고
    • Antagonism of doxorubicin cardiotoxicity by carnitine is specific of the L-diastereoisomer
    • Maccari, F., and Ramacci, M. T. (1981) Antagonism of doxorubicin cardiotoxicity by carnitine is specific of the L-diastereoisomer. Biomedicine 35, 65-67
    • (1981) Biomedicine , vol.35 , pp. 65-67
    • Maccari, F.1    Ramacci, M.T.2
  • 20
    • 0022470575 scopus 로고
    • Protective effect of L-carnitine on cardiac metabolic damage induced by doxorubicin in vitro
    • Neri, B., Cini-Neri, G., Bartalucci, S., and Bandinelli, M. (1986) Protective effect of L-carnitine on cardiac metabolic damage induced by doxorubicin in vitro. Anticancer Res. 6, 659-662
    • (1986) Anticancer Res. , vol.6 , pp. 659-662
    • Neri, B.1    Cini-Neri, G.2    Bartalucci, S.3    Bandinelli, M.4
  • 24
    • 0010045391 scopus 로고    scopus 로고
    • Effect of L-carnitine on Fas-induced apoptosis and sphingomyelinase activity in human T cell lines
    • (De Simone, C., and Famularo, G., eds) Landes Bioscience
    • Alesse, E., Di Marzio, L., Roncaioli, P., Zazzeroni, F., Angelucci, A., Ruggeri, B., Trotta, I., Muzi, P., and Cifone, G. (1997) Effect of L-carnitine on Fas-induced apoptosis and sphingomyelinase activity in human T cell lines. In Carnitine Today (De Simone, C., and Famularo, G., eds) pp. 105-117, Landes Bioscience
    • (1997) Carnitine Today , pp. 105-117
    • Alesse, E.1    Di Marzio, L.2    Roncaioli, P.3    Zazzeroni, F.4    Angelucci, A.5    Ruggeri, B.6    Trotta, I.7    Muzi, P.8    Cifone, G.9
  • 25
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Böse, R., Verheij, M., Haimovitz-Friedman, A., Scotto, K., Fuks, Z., and Kolesnick, R. (1995) Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82, 405-414
    • (1995) Cell , vol.82 , pp. 405-414
    • Böse, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.6
  • 27
    • 0030694255 scopus 로고    scopus 로고
    • Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
    • Perez, G. I., Knudson, C. M., Leykin, L., Korsmeyer, S. J., and Tilly, J. L. (1997) Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction. Nat. Med. 3, 1228-1232
    • (1997) Nat. Med. , vol.3 , pp. 1228-1232
    • Perez, G.I.1    Knudson, C.M.2    Leykin, L.3    Korsmeyer, S.J.4    Tilly, J.L.5
  • 28
    • 0030670626 scopus 로고    scopus 로고
    • Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
    • Herr, I., Wilhelm, D., Bohler, T., Angel, P., and Debatin, K. M. (1997) Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16, 6200-6208
    • (1997) EMBO J. , vol.16 , pp. 6200-6208
    • Herr, I.1    Wilhelm, D.2    Bohler, T.3    Angel, P.4    Debatin, K.M.5
  • 29
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y. A. (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 30
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • Kolesnick, R. N., and Kronke, M. (1998) Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60, 643-665
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 643-665
    • Kolesnick, R.N.1    Kronke, M.2
  • 31
    • 0025934998 scopus 로고
    • Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein
    • Jaffrézou, J. P., Herbert, J. M., Levade, T., Gau, M. N., Chatelain, P., Laurent, G. (1991) Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein. J. Biol. Chem. 266, 19858-19864
    • (1991) J. Biol. Chem. , vol.266 , pp. 19858-19864
    • Jaffrézou, J.P.1    Herbert, J.M.2    Levade, T.3    Gau, M.N.4    Chatelain, P.5    Laurent, G.6
  • 33
    • 0027512102 scopus 로고
    • A safe and rapid method for analyzing apoptosis-induced fragmentation of DNA extracted from tissues or cultured cells
    • Prigent, P., Blanpied, C., Aten, J., and Hirsch, F. (1993) A safe and rapid method for analyzing apoptosis-induced fragmentation of DNA extracted from tissues or cultured cells. J. Immunol. Methods 160, 139-140
    • (1993) J. Immunol. Methods , vol.160 , pp. 139-140
    • Prigent, P.1    Blanpied, C.2    Aten, J.3    Hirsch, F.4
  • 34
    • 0028323164 scopus 로고
    • A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry
    • Gong, J., Traganos, F., and Darzynkiewicz, Z. (1994) A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal. Biochem. 218, 314-319
    • (1994) Anal. Biochem. , vol.218 , pp. 314-319
    • Gong, J.1    Traganos, F.2    Darzynkiewicz, Z.3
  • 35
    • 0017610392 scopus 로고
    • Simple and rapid fluorometric method for DNA microassay
    • Kapuscinski, J., and Skooczylas, B. (1977) Simple and rapid fluorometric method for DNA microassay. Anal. Biochem. 83, 252-257
    • (1977) Anal. Biochem. , vol.83 , pp. 252-257
    • Kapuscinski, J.1    Skooczylas, B.2
  • 36
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 37
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 38
    • 0028810984 scopus 로고
    • Low temperatures and hypertonicity do not block cytokine-induced stimulation of the sphingomyelin pathway but inhibit nuclear factor-kappa B activation
    • Andrieu, N., Salvayre, R., Jaffrézou, J. P., and Levade, T. (1995) Low temperatures and hypertonicity do not block cytokine-induced stimulation of the sphingomyelin pathway but inhibit nuclear factor-kappa B activation. J. Biol. Chem. 270, 24518-24524
    • (1995) J. Biol. Chem. , vol.270 , pp. 24518-24524
    • Andrieu, N.1    Salvayre, R.2    Jaffrézou, J.P.3    Levade, T.4
  • 39
    • 0343879238 scopus 로고
    • Assay of inorganic phosphate, total phosphate and phosphatases
    • Ames, B. N. (1966) Assay of inorganic phosphate, total phosphate and phosphatases. Methods Enzymol. 8, 115-118
    • (1966) Methods Enzymol. , vol.8 , pp. 115-118
    • Ames, B.N.1
  • 40
    • 0029556391 scopus 로고
    • Ceramide quantitation: Evaluation of a mixed micellar assay using E. coli diacylglycerol kinase
    • van Veldhoven, P. P., Bishop, W. R., Yurivich, D. A., and Bell, R. M. (1995) Ceramide quantitation: evaluation of a mixed micellar assay using E. coli diacylglycerol kinase. Biochem. Mol. Biol. Int. 36, 21-30
    • (1995) Biochem. Mol. Biol. Int. , vol.36 , pp. 21-30
    • Van Veldhoven, P.P.1    Bishop, W.R.2    Yurivich, D.A.3    Bell, R.M.4
  • 41
    • 0015951217 scopus 로고
    • Determination of long-chain base in glycosphingolipids with fluorescamine
    • Kisic, A., and Rapport, M. M. (1974) Determination of long-chain base in glycosphingolipids with fluorescamine. J. Lipid Res. 15, 179-180
    • (1974) J. Lipid Res. , vol.15 , pp. 179-180
    • Kisic, A.1    Rapport, M.M.2
  • 43
    • 0028108015 scopus 로고
    • Functional dichotomy of neutral and acid sphingomyelinases in tumor necrosis factor signaling
    • Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., and Krönke, M. (1994) Functional dichotomy of neutral and acid sphingomyelinases in tumor necrosis factor signaling. Cell 78, 1005-1015
    • (1994) Cell , vol.78 , pp. 1005-1015
    • Wiegmann, K.1    Schütze, S.2    Machleidt, T.3    Witte, D.4    Krönke, M.5
  • 45
    • 0030612721 scopus 로고    scopus 로고
    • Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells
    • Boland, M. P., Foster, S. J., and O'Neill, L. A. (1997) Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. J. Biol. Chem. 272, 12952-12960
    • (1997) J. Biol. Chem. , vol.272 , pp. 12952-12960
    • Boland, M.P.1    Foster, S.J.2    O'Neill, L.A.3
  • 46
    • 0029729842 scopus 로고    scopus 로고
    • Apoptosis in the heart: When and why?
    • Bromme, H. J., and Holtz, J. (1996) Apoptosis in the heart: when and why? Mol. Cell. Biochem. 163, 261-275
    • (1996) Mol. Cell. Biochem. , vol.163 , pp. 261-275
    • Bromme, H.J.1    Holtz, J.2
  • 47
    • 0032526374 scopus 로고    scopus 로고
    • Apoptosis: Basic mechanisms and implications for cardiovascular disease
    • Haunstetter, A., and Izumo, S. (1998) Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ. Res. 82, 1111-1129
    • (1998) Circ. Res. , vol.82 , pp. 1111-1129
    • Haunstetter, A.1    Izumo, S.2
  • 48
    • 0030829808 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy
    • Li, Q., Li, B., Wang, X., Leri, A., Jana, K. P., Liu, Y., Kajstura, J., Baserga, R., and Anversa, P. (1997) Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J. Clin. Invest. 100, 1991-1999
    • (1997) J. Clin. Invest. , vol.100 , pp. 1991-1999
    • Li, Q.1    Li, B.2    Wang, X.3    Leri, A.4    Jana, K.P.5    Liu, Y.6    Kajstura, J.7    Baserga, R.8    Anversa, P.9
  • 49
    • 0032498614 scopus 로고    scopus 로고
    • Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol
    • Yue, T. L., Ma, X. L., Wang, X., Romanic, A. M., Liu, G. L., Louden, C., Gu, J. L., Kumar, S., Poste, G., Ruffolo, R. R. Jr, and Feuerstein, G. Z. (1998) Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol. Circ. Res. 82, 166-174
    • (1998) Circ. Res. , vol.82 , pp. 166-174
    • Yue, T.L.1    Ma, X.L.2    Wang, X.3    Romanic, A.M.4    Liu, G.L.5    Louden, C.6    Gu, J.L.7    Kumar, S.8    Poste, G.9    Ruffolo R.R., Jr.10    Feuerstein, G.Z.11
  • 56
    • 0032079524 scopus 로고    scopus 로고
    • Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death
    • Liu, B., Andrieu-Abadie, N., Levade, T., Zhang, P., Obeid, L. M., and Hannun, Y. A. (1998) Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J. Biol. Chem. 273, 11313-11320
    • (1998) J. Biol. Chem. , vol.273 , pp. 11313-11320
    • Liu, B.1    Andrieu-Abadie, N.2    Levade, T.3    Zhang, P.4    Obeid, L.M.5    Hannun, Y.A.6
  • 59
    • 0031018842 scopus 로고    scopus 로고
    • Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HPV syndrome
    • Cossarizza, A., Mussini, C., Mongiardo, N., Borghi, V., Sabbatini, A., De Rienzo, B., and Franceschi, C. (1997) Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HPV syndrome. AIDS 11, 19-26
    • (1997) AIDS , vol.11 , pp. 19-26
    • Cossarizza, A.1    Mussini, C.2    Mongiardo, N.3    Borghi, V.4    Sabbatini, A.5    De Rienzo, B.6    Franceschi, C.7
  • 60
    • 0023179879 scopus 로고
    • Changes in levels of lipid peroxides and activities of superoxide dismutase and catalase in isoproterenol induced myocardial infarction in rats
    • Kumari, S. S., and Menon, V. P. (1987) Changes in levels of lipid peroxides and activities of superoxide dismutase and catalase in isoproterenol induced myocardial infarction in rats. Indian J. Exp. Biol. 25, 419-23
    • (1987) Indian J. Exp. Biol. , vol.25 , pp. 419-423
    • Kumari, S.S.1    Menon, V.P.2
  • 61
    • 0030855953 scopus 로고    scopus 로고
    • Adriamycin cardiomyopathy: Pathophysiology and prevention
    • Singal, P. K., Iliskovic, N., Li, T., and Kumar, D. (1997) Adriamycin cardiomyopathy: pathophysiology and prevention. FASEB J. 11, 931-936
    • (1997) FASEB J. , vol.11 , pp. 931-936
    • Singal, P.K.1    Iliskovic, N.2    Li, T.3    Kumar, D.4
  • 62
    • 0019817511 scopus 로고
    • Mechanism of adriamycin cardiotoxicity: Evidence for oxidative stress
    • Olson, R. D., Boerth, R. C., Gerber, J. G., and Nies, A. S. (1981) Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress. Life Sci. 29, 1393-1401
    • (1981) Life Sci. , vol.29 , pp. 1393-1401
    • Olson, R.D.1    Boerth, R.C.2    Gerber, J.G.3    Nies, A.S.4
  • 63
    • 0023726412 scopus 로고
    • Adriamycin-induced free radical formation in the perfused rat heart: Implications for cardiotoxicity
    • Rajagopalan, S., Politi, P. M., Sinha, B. K., and Myers, C. E. (1988) Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity. Cancer Res. 48, 4766-4769
    • (1988) Cancer Res. , vol.48 , pp. 4766-4769
    • Rajagopalan, S.1    Politi, P.M.2    Sinha, B.K.3    Myers, C.E.4
  • 64
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
    • Garcia-Ruiz, C., Colell, A., Mari, M., Morales, A., and Fernandez-Checa, J. C. (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272, 11369-11377
    • (1997) J. Biol. Chem. , vol.272 , pp. 11369-11377
    • Garcia-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 65
    • 1842375100 scopus 로고    scopus 로고
    • Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
    • Quillet-Mary, A., Jaffrézou, J-P., Mansat, V., Bordier, C., Naval, J., and Laurent, G. (1997) Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 272, 21388-21395
    • (1997) J. Biol. Chem. , vol.272 , pp. 21388-21395
    • Quillet-Mary, A.1    Jaffrézou, J.-P.2    Mansat, V.3    Bordier, C.4    Naval, J.5    Laurent, G.6
  • 66
    • 0031013369 scopus 로고    scopus 로고
    • Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis
    • Paumen, M. B., Ishida, Y., Muramatsu, M., Yamamoto, M., and Honjo, T. (1997) Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J. Biol. Chem. 272, 3324-3329
    • (1997) J. Biol. Chem. , vol.272 , pp. 3324-3329
    • Paumen, M.B.1    Ishida, Y.2    Muramatsu, M.3    Yamamoto, M.4    Honjo, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.