Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro

Clinical Cancer Research

Volumn 3, Issue 4, 1997, Pages 579-585

  Faraoni, Isabella ^a   Turriziani, Mario ^a   Masci, Giovanna ^a   De Vecchis, Liana ^a   Shay, Jerry W ^c   Bonmassar, Enzo ^a,b   Graziani, Grazia ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; TELOMERASE; TEMOZOLOMIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL DIVISION; CELL SURVIVAL; CISPLATIN; DACARBAZINE; DENSITOMETRY; DOXORUBICIN; HUMANS; JURKAT CELLS; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TELOMERASE; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; U937 CELLS;

EID: 0030973269     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Fruehauf, J. P., and Bosanquet, A. G. In vitro determination of drug response: a discussion of clinical applications. In: V. T. De Vita, Jr., S. Hellman, and S. A. Rosenberg (eds.) Cancer: Principles and Practices of Oncology, pp. 1-16. Philadelphia: J. B. Lippincott Co., 1993.
2. Shay, J. W., and Wright, W. E. Telomerase activity in human cancer. Curr. Opin. Oncol., 8: 66-71, 1996.
3. Morin, G. B. The human telomerase terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell, 59: 521-529, 1989.
4. Shay, J. W. Aging and cancer: are telomeres and telomerase the connection? Mol. Med. Today, 1: 378-384, 1995.
5. Rhyu, M. S. Telomeres, telomerase, and immortality. J. Natl. Cancer Inst., 87: 884-894, 1995.
6. Broccoli, D., Young, J. W., and De Lange, T. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA, 92: 9082-9086, 1995.
7. Holt, S. E., Wright, W. E., and Shay, J. W. Regulation of telomerase activity in immortal cell lines. Mol. Cell. Biol., 16: 2932-2939, 1996.
8. Hiyama, E., Hiyama, K., Tatsumoto, N., Shay, J. W., and Yokoyama, T. Telomerase activity in human intestine. Int. J. Oncol., 9: 453-458, 1996.
9. Taylor, R. S., Ramirez, R. D., Ogoshi, M., Chaffins, M., Piatyszek, M. A., and Shay, J. W. Telomerase activity in malignant and nonmalignant skin conditions. J. Invest. Dermatol., 106: 759-765, 1996.
10. Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyman, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., and Yamakido, M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol., 155: 3711-3715, 1995.
11. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 260: 2011-2015, 1994.
12. Wright, W. E., Shay, J. W., and Piatyszek, M. A. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res., 23: 3794-3795, 1995.
13. Hiyama, E., Yokoyama, T., Tatsumoto, N., Hiyama, K., Imamura, Y., Murakami, Y., Kodama, T., Piatyszek, M. A., Shay, J. W., and Matsuura, Y. Telomerase activity in gastric cancer. Cancer Res., 55: 3258-3262, 1995.
14. Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M. A., and Shay, J. W. Correlating telomerase activity levels with human neuroblastoma outcomes. Nat. Med., 1: 249-257, 1995.
15. Zhang, W., Piatyszek, M. A., Estey, E., Kobayashi, T., Andreff, M., Deisseroth, A. B., Wright, W. E., and Shay, J. W. Telomerase activity in acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agent. Clin. Cancer Res., 2: 799-803, 1996.
16. Akman, S. A., Forrest, G., Chu, F. F., Esworthy, R. S., and Doroshow, J. H. Antioxidant and xenobiotic-metabolizing enzyme gene expression in doxorubicin-resistant MCF-7 breast cancer cells. Cancer Res., 50: 1397-1402, 1990.
17. Stevens, M. F. G., Hickman, J. A., Langdon, S. P., Chubb, D., Vickers, L., Stone, R., Baig, G., Goddard, C., Gobson, N. W., Slack, J. A., Newton, C., Lunt, E., Fizames, C., and Lavelle, F. Amitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine. Cancer Res., 47: 5846-5852, 1987.
18. Hansen, M. B., Nielsen, S. E., and Berg, K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods, 119: 203-210, 1989.
19. Piatyszek, M. A., Kim, N. W., Weinrich, S. L., Hiyama, K., Hiyama, E., Wright, W. E., and Shay, J. W. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Methods Cell Sci., 17: 1-15, 1995.
20. O'Brien, S., Kantarjian, H., Freireich, E., Johnston, D., Nguyen, K., and Beran, M. CI-973, a new platinum derivative with potential antileukemic activity. Cancer Res., 52: 4130-4134, 1992.
21. 6-alkylguanine-DNA alkyltransferase deficient leukemia cell lines. Leukemia (Baltimore), 9: 1888-1895, 1995.
22. Newlands, E. S., Blackledge, G. R. P., Slack, J. A., Rustin, G. J. S., Smith, D. B., Stuart, N. S. A., Quarterman, C. P., Hoffman, R., Stevens, M. F. G., Brampton, M. H., and Gibson, A. C. Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856). Br. J. Cancer, 65: 287-291, 1992.
23. Holt, S. E., Wright, W. E., and Shay J. W. Regulation of telomerase activity in immortal cell lines. Mol. Cell. Biol., 16: 2932-2939, 1996.
24. Kwok, T. T., Mok, C. H., and Menton-Brennan, L. Up-regulation of a mutant form of p53 by doxorubicin in human squamous carcinoma cells. Cancer Res., 54: 2834-2836, 1994.
25. Zhu, X., Kumar, R., Mandal, M., Sharma, N., Sharma, H. W., Dhingra, U., Sokoloski, J. A., Hsiao, R., and Narayanan, R. Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc. Natl. Acad. Sci. USA, 93: 6091-6095, 1996.
26. Nishio, K., Fujiwara, Y., Miyahara, Y., Takeda, Y., Ohira, T., Kubota, N., Ohta, S., Funayama, Y., Ogasawara, H., Ohata, M., and Saijo, N. cis-diamminedichloroplatinum(II) inhibits p34cdc2 protein kinase in human lung-cancer cells. Int. J. Cancer, 55: 616-622, 1993.
27. Hiyama, E., Gollahon, L., Kataoka, T., Katsumasa, K., Yokoyama, T., Gazdar, A. F., Hiyama, K., Piatyszek, M. A., and Shay, J. W. Telomerase activity in human breast tumors. J. Natl. Cancer Inst., 86: 116-122, 1996.
28. Tahara, H., Nakanishi, T., Kitamoto, M., Nakashio, R., Shay, J. W., Tahara, E., Kajiyama, G., and Ide, T. Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res., 55: 2734-2736, 1995.
29. Nouso, K., Urabe, Y., Higashi, T., Nakatsukasa, H., Hino, N., Ashida, K., Kinugasa N., Yoshida K., Uematsu S., and Tsuji T. Telomerase as a tool for the differential diagnosis of human hepatocellular carcinoma. Cancer (Phila.), 78: 232-236, 1996.