Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 8, 1998, Pages 887-895

  Hayashi, Takeshi ^a   Abe, Koji ^b   Itoyama, Yasuto ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Brain edema; Brain infarct; HSP70; TUNEL; VEGF

Indexed keywords

DOUBLE STRANDED DNA; EVANS BLUE; GELFOAM; HEAT SHOCK PROTEIN 70; RECOMBINANT VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN PERFUSION; CELL DAMAGE; CONTROLLED STUDY; EXTRAVASATION; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSIENT ISCHEMIC ATTACK;

EID: 0031826273     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199808000-00009     Document Type: Article

References (48)

1. Abe K, Araki T, Kogure K (1988) Recovery from edema and of protein synthesis differs between the cortex and caudate following transient focal cerebral ischemia in rats. J Neurochem 51:1470-1476
2. Abe K, Kawagoe J, Araki T, Aoki M, Kogure K (1992) Differential expression of heat shock protein 70 gene between the cortex and caudate after transient focal cerebral ischemia in rats. Neurol Res 14:381-385
3. Abe K, Hayashi T, Itoyama Y (1997) Amelioration of brain edema by topical application of glial cell line-derived neurotrophic factor in reperfused rat brain. Neurosci Lett 231:37-40
4. Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1:1024-1028
5. Bacic M, Edwards NA, Merrill MJ (1995) Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues. Growth Factors 12:11-15
6. Banai S, Jaklitsch MT, Shou M, Lazarous DF, Scheinowitz M, Biro S, Epstein SE, Unger EF (1994) Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 89:2183-2189
7. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM (1995) Recovery of endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation 91: 2802-2809
8. Betz AL, Coester HC (1990) Effect of steroids on edema and sodium uptake of the brain during focal ischemia in rats. Stroke 21:1199-1204
9. Betz Al, Ennis SR, Schielke GP (1989) Blood-brain barrier sodium transport limits development of brain edema during partial ischemia in gerbils. Stroke 20:1253-1259
10. Bruce JN, Criscuolo GR, Merrill MJ, Moquin RR, Blacklock JB, Oldfield EH (1987) Vascular permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone. J Neurosurg 67:880-884
11. Cao Y, Chen H, Zhou L, Chiang MK, Anand-Apte B, Weatherbee JA, Wang Y, Fang F, Flanagan JG, Tsang MLS (1996) Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J Biol Chem 271:3154-3162
12. Chen HH, Chien CH, Liu HM (1994) Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct. Stroke 25:1651-1657
13. Connolly DT, Olander JV, Heuvelman D, Nelson R, Monsell R, Siegel N, Haymore BL, Leimgruber R, Feder J (1989) Human vascular permeability factor. J Biol Chem 264:20017-20024
14. Criscuolo GR, Merrill MJ, Oldfield EH (1990) Characterization of a protein product of human malignant glial tumors that induces microvascular permeability. Adv Neurol 52:469-474
15. Fisher S, Sharma HS, Karliczek GF, Schaper W (1995) Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine. Mol Brain Res 28:141-148
16. Fishman RA (1982) Steroids in the treatment of brain edema. N Engl J Med 306:359-360
17. Folkman J, Shing Y (1992) Angiogenesis. J Biol Chem 267:10931-10934
18. Gething MJ, Sambrook J (1992) Protein folding in the cell. Nature 355:33-45
19. 121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells. J Biol Chem 271:5519-5523
20. Gonzalez MF, Shiraishi K, Hisanaga K, Sagar SM, Mandabach M, Sharp FR (1989) Heat shock proteins as a marker of neuronal injury. Mol Brain Res 6:93-100
21. Hammes HP, Brownlee M, Jonczyk A, Sutler A, Preissner KT (1996) Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. Nat Med 2:529-533
22. Hashimoto E, Ogita T, Nakaoka T, Matsuoka R, Takao A, Kira J (1994) Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am J Physiol 267:H1948-H1954
23. Hayashi T, Abe K, Suzuki H, Itoyama Y (1997) Rapid induction of VEGF gene expression after transient MCA occlusion in rat. Stroke 28:2039-2044
24. Heiss JD, Papavassiliou E, Merrill MJ, Nieman L, Knightly JJ, Walbridge S, Edwards NA, Oldfield EH (1996) Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. J Clin Invest 98:1400-1408
25. Ijichi A, Sakuma S, Tofilon PJ (1995) Hypoxia-induced vascular endothelial growth factor expression in normal rat astrocyte cultures. Glia 14:87-93
26. Isner JM, Walsh K, Symes J, Pieczek A, Takeshita S, Lowry J, Rossow S, Rosenfield K, Weir L, Brogi E, Schainfeld R (1995) Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease. Circulation 91:2687-2692
27. Kawagoe J, Abe K, Ikuta J, Igarashi N, Shimizu S, Yamauchi Y, Kogure K (1992) Effect of dilazep dihydrochloride against ischemia and reperfusion induced disruption of blood-brain barrier in rats: a quantitative study. Arch Pharmacol 345:485-488
28. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be induced in the ischemic area. Jpn J Stroke 8:1-7
29. Kovacs Z, Ikezaki K, Samoto K, Inamura T, Fukui M (1996) VEGF and flt. Expression time kinetics in rat brain infarct. Stroke 27: 1865-1873
30. Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM (1994) Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25: 1794-1798
31. Krupinski J, Issa R, Bujny T, Slevin M, Kumar P, Kumar S, Kaluza J (1997) A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans. Stroke 28:564-573.
32. Ku DD, Zaleski JK, Liu S, Brock TA (1993) Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am J Physiol 265:H586-H592
33. Lee TH, Abe K, Aoki M, Nakamura M, Kogure K, Itoyama Y (1994) The protective effect of L-threo-3,4-dihydroxyphenylserine on ischemic hippocampal neuronal death in gerbils. Stroke 25:1425-1432
34. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306-1309
35. Monacci WT, Merrill MJ, Oldfield EH (1993) Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am J Physiol 264:C995-C1002
36. Nagasawa H, Kogure K (1989) Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 20:1037-1043
37. Nikolics K, Hefti F, Thomas GR, Gluckman PD (1996) Trophic factors and their role in the postischemic brain. In: Advances in Neurology, Vol. 71: Cellular and Molecular Mechanisms of Ischemic Brain Damage. (Siesjo BK, Weiloch T, eds), Philadelphia, Lippincott-Raven Publishers, pp 389-403
38. Nomura M, Yamagishi S, Harada S, Hayashi Y, Yamashima T, Yamashima J, Yamamoto H (1995) Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial cells and pericytes. J Biol Chem 270:28316-28324
39. Otto D, Frotscher M, Uniscker K (1989) Basic fibroblast growth factor and nerve growth factor administrated in gel foam rescue medial septal neurons after fimbria fornix transection. J Neurosci Res 22:83-91
40. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LEH (1995) Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA 92:905-909
41. Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845
42. Smith JEH, Kopchick JJ, Chen W, Knapp J, Kinose F, Daley D, Foley E, Smith RG, Schaeffer JM (1997) Essential role of growth hormone in ischemia-induced retinal neovascularization. Science 276: 1706-1709
43. States BA, Honkaniemi J, Weinstein PR, Sharp FR (1996) DNA fragmentation and HSP70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusions. J Cereb Blood Flow Metab 16:1165-1175
44. Takeshita S, Pu LQ, Stein LA, Sniderman AD, Bunting S, Ferrara N, Isner JM, Symes JF (1994a) Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation 90(Part 2):228-234
45. Takeshita S, Zheng LP, Brogi E, Kearney M, Pu LQ, Bunting S, Ferrara N, Symes J, Isner JM (1994e) Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest 93:662-670
46. Tsurumi Y, Murohara T, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinhal T, Isner JM (1997) Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nat Med 3:879-886
47. Wang W, Merrill MJ, Borchardt RT (1996) Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro. Am J Physiol 271:C1973-C1980
48. Yoshimoto T, Houkin K, Takahashi A, Abe H (1996) Angiogenic factors in moyamoya disease. Stroke 27:2160-2165