Mitochondrial membrane potential in aging cells

NeuroSignals

Volumn 10, Issue 3-4, 2001, Pages 176-188

  Sugrue, Mary M ^a   Tatton, William G ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adenine nucleotide translocase; Aging; Chloromethyl tetramethylrosamine methyl ester; Mitochondrial membrane potential ( Delta; Psi; M); Senescence

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE TRIPHOSPHATE; PROTEIN P53; RHODAMINE 123;

ANIMAL CELL; ARTICLE; CELL AGING; CHANNEL GATING; DEGENERATIVE DISEASE; FIBROBLAST; GENE OVEREXPRESSION; HUMAN; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PARKINSON DISEASE; RAT; SENESCENCE;

AGING; ANIMALS; FIBROBLASTS; HUMANS; INTRACELLULAR MEMBRANES; ION CHANNELS; LIVER; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; RATS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035026498     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000046886     Document Type: Article

References (88)

1. Ames BN, Shigenaga MK, Hagen TM: Mitochondrial decay in aging. Biochim Biophys Acta 1995; 1271: 165-170.
2. Bernardi P, Scorrano L, Colonna R, Petronilli V, Di Lisa F: Mitochondria and cell death. Mechanistic aspects and methodological issues. Eur J Biochem 1999;264:687-701.
3. Nicholls DG, Ferguson SJ: Bioenergetics 2. London, Academic Press, 1992.
4. Kaim G, Dimroth P: ATP synthesis by F-type ATP synthase is obligatorily dependent on the transmembrane voltage. EMBO J 1999; 18: 4118-4127.
5. Tatton WG, Olanow CW: Apoptosis in neurodegenerative diseases: The role of mitochondria. Biochim Biophys Acta 1999;1410:195-213.
6. Crompton M, Virji S, Ward JM: Cy-clophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Eur J Biochem 1998;258:729-735.
7. Woodfield K, Ruck A, Brdziczka D, Halestrap AP: Direct demonstration of a specific interaction between cy-clophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. Biochem J 1998;336: 287-290.
8. Bernardi P, Colonna R, Costantini P, Eriksson O, Fontaine E, Massari S, Nicolli A, Petronilli V, Scorrano L: The mitochondrial permeability transition. Biofactors 1998;8:273-281.
9. 2+-sen-sitive cyclical mitochondrial depolarizations in cell culture. Biochim Biophys Acta 1999;1410:77-84.
10. Ichas F, Mazat JP: From calcium signaling to cell death: Two conformations for the mitochondrial permeability transition pore. Switching from low-to high-conductance state. Biochim Biophys Acta 1998;1366: 33-50.
11. Ichas F, Jouaville LS, Mazat JP: Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 1997;89:1145-1153.
12. Scorrano L, Petronilli V, Bernardi P: On the voltage dependence of the mitochondrial permeability transition pore-A critical appraisal. J Biol Chem 1997;272:12295-12299.
13. Petronilli V, Costantini P, Scorrano L, Colonna R, Passamonti S, Bernardi P: The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents. J Biol Chem 1994;269: 16638-16642.
14. Halestrap AP, Woodfield KY, Con-nern CP: Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J Biol Chem 1997;272:3346-3354.
15. Scorrano L, Nicolli A, Basso E, Petronilli V, Bernardi P: Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin. Mol Cell Biochem 1997;174:181-184.
16. Nicolli A, Basso E, Petronilli V, Wenger RM, Bernardi P: Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensi-tive channel. J Biol Chem 1996;271: 2185-2192.
17. Patterson SD, Spahr CS, Daugas E, et al: Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition. Cell Death Differ 2000; 7: 137-144.
18. Loeffler M, Kroemer G: The mitochondrion in cell death control: Certainties and incognita. Exp Cell Res 2000;256:19-26.
19. Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G: Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene 1998;16:2265-2282.
20. Korsmeyer SJ: BCL-2 gene family and the regulation of programmed cell death. Cancer Res 1999;59: 1693s-1700s.
21. Marzo I, Brenner C, Zamzami N, et al: Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998;281:2027-2031.
22. Schendel SL, Montal M, Reed JC: Bcl-2 family proteins as ion-channels. Cell Death Differ 1998;5:372-380.
23. Minn AJ, Velez P, Schendel SL, et al: Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature 1997;385:353-357.
24. Rottenberg H, Wu S: Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. Biochim Biophys Acta 1998;1404:393-404.
25. Terasaki M: Fluorescent labeling of endoplasmic reticulum. Methods Cell Biol 1989;29:125-135.
26. Petriz J, O’connor JE, Carmona M, Garcia-Lopez J: Is rhodamine 123 an appropriate fluorescent probe to assess P-glycoprotein mediated multidrug resistance in vinblastine-resistant CHO cells? Anal Cell Pathol 1997;14:129-140.
27. Petriz J, Garcia-Lopez J: Flow cytometric analysis of P-glycoprotein function using rhodamine 123. Leukemia 1997;11:1124-1130.
28. Eytan GD, Regev R, Oren G, Hur-witz CD, Assaraf YG: Efficiency of P-glycoprotein-mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate. Eur J Biochem 1997;248:104-112.
29. Salet C, Moreno G, Ricchelli F, Ber-nardi P: Singlet oxygen produced by photodynamic action causes inactivation of the mitochondrial permeability transition pore. J Biol Chem 1997;272:21938-21943.
30. Atlante A, Passarella S, Quagliariel-lo E, Moreno G, Salet C: Haemato-porphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: Inhibition of ADP/ATP translocator. J Photochem Photo-biol B 1989;4:35-46.
31. Arcadi JA: The effect of rhodamine-123 on 3 prostate tumors from the rat. J Urol 1998;160:2402-2406.
32. Scorrano L, Petronilli V, Colonna R, Di Lisa F, Bernardi P: Chloro-methyltetramethylrosamine (Mito-tracker Orange) induces the mitochondrial permeability transition and inhibits respiratory complex I. Implications for the mechanism of cytochrome c release. J Biol Chem 1999;274:24657-24663.
33. Metivier D, Dallaporta B, Zamzami N, Larochette N, Sussin SA, Marzo I, Kroemer G: Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes. Immunol Lett 1998;61:157-163.
34. Grant SM, Shankar SL, Chalmers-Redman RM, Tatton WG, Szyf M, Cuello AC: Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751). Neuroreport 1999;10:41-46.
35. Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S: Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 1999;94: 2102-2111.
36. Sugrue MM, Wang Y, Rideout HJ, Chalmers-Redman RM, Tatton WG: Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence. Biochem Biophys Res Commun 1999;261:123-130.
37. Wadia JS, Chalmers-Redman RME, Ju WJH, et al: Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by (-)-deprenyl. J Neurosci 1998; 18: 932-947.
38. Chalmers-Redman RM, Fraser AD, Carlile GW, Pong A, Tatton WG: Glucose protection from MPP+-in-duced apoptosis depends on mitochondrial membrane potential and ATP synthase. Biochem Biophys Res Commun 1999;257:440-447.
39. Gilmore K, Wilson M: The use of chloromethyl-X-rosamine (Mito-tracker red) to measure loss of mitochondrial membrane potential in apoptotic cells is incompatible with cell fixation. Cytometry 1999;36: 355-358.
40. Macho A, Decaudin D, Castedo M, et al: Chloromethyl-X-rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis. Cytometry 1996; 25:333-340.
41. Poot M, Pierce RC: Detection of apoptosis and changes in mitochondrial membrane potential with chloromethyl-X-rosamine. Cytometry 1999;36:359-360.
42. Ferlini C, Scambia G, Fattorossi A: Is chloromethyl-X-rosamine useful in measuring mitochondrial transmembrane potential? Cytometry 1998;31:74-75.
43. Minamikawa T, Sriratana A, Williams DA, Bowser DN, Hill JS, Na-gley P: Chloromethyl-X-rosamine (MitoTracker Red) photosensitizes mitochondria and induces apoptosis in intact human cells. J Cell Sci 1999;112:2419-2430.
44. Wikowski JM, Micklem HS: Decreased membrane potential of T lymphocytes in ageing mice: Flow cytometric studies with a carbocyan-ine dye. Immunology 1985;56:307-313.
45. Witkowski JM, Micklem HS: Evidence for decreased transmembrane potential of T lymphocytes in ageing mice; in Pepeu G (ed): New Trends in Ageing Research. Rijswijk, Eu-rage, 1986, pp 45-51.
46. Leprat P, Ratinaud MH, Julien R: A new method for testing cell ageing using two mitochondria specific fluorescent probes. Mech Ageing Dev 1990;52:149-167.
47. Darzynkiewicz Z, Staiano-Coico L, Melamed MR: Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation. Proc Natl Acad Sci USA 1981;78:2383-2387.
48. Pieri C, Recchioni R, Moroni F: Age-dependent modifications of mitochondrial trans-membrane potential and mass in rat splenic lymphocytes during proliferation. Mech Ageing Dev 1993;70:201-212.
49. Rottenberg H, Shaolong W: Mitochondrial dysfunction in lymphocytes from old mice: Enhanced activation of the permeability transition. Biochem Biophys Res Com-mun 1997;240:68-74.
50. Witkowski JM, Miller RA: Increased function of P-glycoprotein in T lymphocyte subsets of aging mice. J Immunol 1993; 150:1296-1306.
51. Martinez AO, Over D, Armstrong LS, Manzano L, Taylor R, Chambers J: Separation of two populations of old human fibroblasts by mitochondria (rhodamine 123) fluorescence. Growth Dev Aging 1991; 55:185-191.
52. Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park J-Y, Ames BN: Mitochondrial decay in hepatocytes from old rats: Membrane potential decline, heterogeneity and oxidants increase. Proc Natl Acad Sci USA 1997;94:3064-3069.
53. Wilson PD, Franks LM: The effect of age on mitochondrial ultrastructure and enzymes. Adv Exp Med Biol 1975;53:171-183.
54. Pfeuty A, Gueride M: Peroxide accumulation without major mitochondrial alteration in replicative senescence. FEBS Lett 2000;468: 43-47.
55. Harper M-E, Monemdjou S, Ramsey JJ, Weindruch R: Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. Am J Physiol 1998;275:E197-E206.
56. Nobes CD, Brown GC, Olive PN, Brand MD: Non-ohmic proton conductance of the mitochondrial inner membrane in hepatocytes. J Biol Chem 1990;265:12903-12909.
57. Fan WM, Kou H, Shen DJ, LeRoy EC: Identification of altered expression of ADP/ATP translocase during cellular senescence in vitro. Exp Gerontol 1998;33:457-465.
58. Sugrue MM, Shin DY, Lee SW, Aa-ronson SA: Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci USA 1997;94: 9648-9653.
59. Langston JW, Ballard P, Tetrud JW, Irwin I: Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983;219:979-980.
60. Langston JW, Forno LS, Rebert CS, Irwin I: Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropy-rine (MPTP) in the squirrel monkey. Brain Res 1984;292:390-394.
61. Mizuno Y, Ohta S, Tanaka M, et al: Deficiencies in complex I subunits of the respiratory chain in Parkinson’s disease. Biochem Biophys Res Commun 1989;163:1450-1455.
62. Parker WD Jr, Boyson SJ, Parks JK: Abnormalities of the electron transport chain in idiopathic Parkinson’s disease. Ann Neurol 1989;26:719-723.
63. Schapira AH, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD: Mitochondrial complex I deficiency in Parkinson’s disease. Lancet 1989; i:12-69.
64. Schapira AH, Cooper JM, Dexter D, Clark JB, Jenner P, Marsden CD: Mitochondrial complex I deficiency in Parkinson’s disease. J Neuro-chem 1990;54:823-827.
65. Schapira AH, Mann VM, Cooper JM, et al: Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson’s disease. J Neurochem 1990;55:2142-2145.
66. Swerdlow RH, Parks JK, Miller SW, et al: Origin and functional consequences of the complex I defect in Parkinson’s disease. Ann Neurol 1996;40:663-671.
67. Krige D, Carroll MT, Cooper JM, Marsden CD, Schapira AH: Platelet mitochondrial function in Parkinson’s disease. Ann Neurol 1992;32: 782-788.
68. Mann VM, Cooper JM, Krige D, Daniel SE, Schapira AH, Marsden CD: Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson’s disease. Brain 1992;115:333-342.
69. Yoshino H, Nakagawa Hattori Y, Kondo T, Mizuno Y: Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson’s disease. J Neural Transm Park Dis Dement Sect 1992;4:27-34.
70. Mytilineou C, Werner P, Molinari S, DiRocco A, Cohen G, Yahr MD: Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson’s disease. J Neural Transm Park Dis Dement Sect 1994;8:223-228.
71. Shults CW, Haas RH, Passov D, Beal MF: Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol 1997; 42:261-264.
72. Hattori N, Tanaka M, Ozawa T, Mizuno Y: Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson’s disease. Ann Neurol 1991;30:563-571.
73. Mizuno Y, Ikebe S, Hattori N, et al: Role of mitochondria in the etiology and pathogenesis of Parkinson’s disease. Biochim Biophys Acta 1995; 1271:265-274.
74. Brown MD, Shoffner JM, Kim YL, et al: Mitochondrial DNA sequence analysis of four Alzheimer’s and Parkinson’s disease patients. Am J Med Genet 1996;61:283-289.
75. Schapira AH: Nuclear and mitochondrial genetics in Parkinson’s disease. J Med Genet 1995;32:411-414.
76. Lucking CB, Kosel S, Mehraein P, Graeber MB: Absence of the mitochondrial A7237T mutation in Parkinson’s disease. Biochem Biophys Res Commun 1995;211:700-704.
77. Chiba K, Trevor A, Castagnoli N Jr: Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun 1984;120:574-578.
78. Chiba K, Trevor AJ, Castagnoli N Jr: Active uptake of MPP+, a metabolite of MPTP, by brain synapto-somes. Biochem Biophys Res Com-mun 1985;128:1228-1232.
79. Mizuno Y, Sone N, Saitoh T: Dopaminergic neurotoxins MPTP and MPP-+ inhibit activity of mitochondrial NADH-ubiquinone oxidore-ductase. Proc Jpn Acad Ser B Phys Biol Sci 1986;62:261-263.
80. Mizuno Y, Suzuki K, Sone N, Saitoh T: Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium (MPP+) in isolated mitochondria from mouse brains. Neurosci Lett 1987;81:204-208.
81. Nicklas WJ, Vyas I, Heikkila RE: Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 1985;36:2503-2508.
82. Davey GP, Clark JB: Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. J Neurochem 1996; 66:1617-1624.
83. Camins A, Sureda FX, Gabriel C, Pallas M, Escubedo E, Camarasa J: Effect of 1-methyl-4-phenylpyridin-ium (MPP+) on mitochondrial membrane potential in cerebellar neurons: Interaction with the NMDA receptor. J Neural Transm 1997;104:569-577.
84. Fall CP, Bennett JP Jr: Characterization and time course of MPP+-induced apoptosis in human SH-SY5Y neuroblastoma cells. J Neu-rosci Res 1999;55:620-628.
85. Wu EY, Smith MT, Bellomo G, Di Monte D: Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepato-cytes. Arch Biochem Biophys 1990; 282:358-362.
86. Singh Y, Bhatnagar R, Sidhu GS, Batra JK, Krishna G: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits proton motive force in energized liver mitochondria. Arch Bio-chem Biophys 1989;271:217-222.
87. Lambert CE, Bondy SC: Effects of MPTP, MPP+ and paraquat on mitochondrial potential and oxidative stress. Life Sci 1989;44:1277-1284.
88. Tatton WG, Chalmers-Redman RM: Mitochondria in neurodegenerative apoptosis: An opportunity for therapy? Ann Neurol 1998;44: S134-141