Effect of 1-methyl-4-phenylpyridinium (MPP+) on mitochondrial membrane potential in cerebellar neurons: Interaction with the NMDA receptor

Journal of Neural Transmission

Volumn 104, Issue 6-7, 1997, Pages 569-577

  Gamins, A ^a   Sureda, F X ^a   Gabriel, C ^a   Pallas M ^a   Escubedo, E ^a   Camarasa, J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

1 methyl 4 phenylpyridinium; Flow cytometry; Mitochondrial membrane potential; NMDA antagonists; Rhodamine 123

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2 AMINO 5 PHOSPHONOVALERIC ACID; 5,7 DICHLOROKYNURENIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; CINCHOCAINE; DESIPRAMINE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTOXIN; PARTIAL AGONIST; PHOSPHOLIPASE A2; RHODAMINE 123; RILUZOLE;

ANIMAL CELL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; GRANULE CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CEREBELLUM; DOPAMINE AGENTS; FLOW CYTOMETRY; INTRACELLULAR MEMBRANES; LOGISTIC MODELS; MEMBRANE POTENTIALS; MITOCHONDRIA; NEURONS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0030694888     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01291876     Document Type: Article

References (28)

1. Adams JD, Odunze IN (1991) Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: could oxidative stress be involved in the brain? Biochem Pharmacol 41: 1099-1105
2. + neurotoxicity against rat dopaminergic neurons in culture. Neurosci Lett 193: 53-56
3. -) neurotoxicity against dopaminergic neurons in coculture of rat mesencephalon with their target and non-target regions. Neurosci Res 23: 53-66
4. Brouillet E, Beal MF (1993) NMDA antagonists partially protect against MPTP induced neurotoxicity in mice. Neurochemistry 4: 387-390
5. Cadet JL, Ali SF, Rothman RB, Epstein CJ (1995) Neurotoxicity, drugs abuse and the CuZn-superoxide dismutase transgenic mice. Mol Neurobiol 11: 155-163
6. -). Neurosci Lett 117: 129-133
7. Chan P, DeLanney LE, Irwin I, Langsten JM, DiMonte D (1991) Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain. J Neurochem 57: 348-351
8. +: possible action at the dopamine transporter. Br J Pharmacol 114: 315-322
9. Cleeter MWJ, Cooper JM, Schapira AHV (1992) Irreversible inhibition of mitochondrial complex 1 by 1-methyl-4-phenylpyridinium: evidence for free radical involvement. J Neurochem 58: 786-792
10. Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nature Med 2: 1017-1021
11. Hsu KS, Huang CC, Gean PW (1995) Voltage and use dependent block by 1-methyl-4-phenylpyridinium ion (MPP) on N-methyl-D-aspartate (NMDA) activated currents in rat hippocampal neurons. Neurosci Lett 189: 17-20
12. Javitch JA, D'Amato RJ, Stritmatter SM, Snyder SH (1985) Parkinsonism-inducing neurotoxin. N-methyl-4-phenyl-1,2,3,6-tetranydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82: 2173-2177
13. Marini AM, Paul SM (1992) N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis. Proc Natl Acad Sci USA 89: 6555-6559
14. Markey SP, Johannessen JN, Chiueh CC, Burns RS, Herkenham MA (1984) Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature 311: 464-467
15. Michel PP, Agid Y (1992) The glutamate antagonist, MK-801. does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP) in rat dissociated mesencephalic cultures. Brain Res 597: 233-240
16. Poirier J, Donaldson J, Barbeau A (1985) The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals. Biochem Biophys Res Commun 128: 25-33
17. +) into adrenal chromaffin cells as a consequence of charge delocalization. Biochem Biophys Res Commun 168: 1143-1148
18. Reynolds IJ, Miller RJ (1988) Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of Zn. Br J Pharmacol 95: 95-102
19. RUSS H, Staudt K, Martel F, Gliese M, Schömig E (1996) The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia. Eur J Neurosci 8: 1256-1264
20. Santiago M, Venero JL, Machado A, Cano J (1992) In vivo protection of striatum from MPP neurotoxicity by N-methyl-D-aspartate antagonist. Brain Res 586: 203-207
21. Sonsalla PK, Zeevalk CD, Manzino L, Giovanni A, Nicklas WJ (1992) MK-801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats. J Neurochem 58: 1972-1989
22. Starr MS (1995) Antiparkinsonian actions of glutamate antagonists-alone and with L-DOPA: a review of evidence and suggestions for possible mechanisms. J Neural Transm [P-D Sect] 10: 141-185
23. Storey E, Hyman BT, Jenkins B, Brouillet E, Miller JM, Rosen BR, Beai MF (1992) 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J Neurochem 58: 1975-1978
24. Sundstrom E, Mo LL (1995) Effects of 1-methyl-4-phenylpyridinium on radioligand binding to the NMDA receptor complex. Res Commun Mol Pathol Pharmacol 88: 131-136
25. Sureda FX, Camins A, Trullas R, Camarasa J, Escubedo E (1996a) A How cytometric study of N-methyl-D-aspartate effects on dissociated cerebellar cells. Brain Res 723: 110-114
26. Sureda FX, Viu E, Zapata A, Capdevila JL, Camins A, Escubedo E, Camarasa J, Trullas R (1996b) Modulation of NMDA-induced cytosolic calcium levels by ACPC in cultured cerebellar granule cells. Neuroreporl 7: 1824-1828
27. Sureda FX, Escubedo E, Gabriel C, Camarasa J, Camins A (1996c) Effect of glutamate receptor ligands on mitochondrial membrane potential in rat dissociated cerebellar cells. Naunyn Schmiedebergs Arch Pharmacol 354: 420-423
28. + neurotoxicity by N-methyl-D-aspartate antagonists. Nature 349: 414-418