Characterization and time course of MPP+-induced apoptosis in human SH- SY5Y neuroblastoma cells

Journal of Neuroscience Research

Volumn 55, Issue 5, 1999, Pages 620-628

  Fall, Christopher P ^a   Bennett Jr , James P ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Apoptosis; Cell death; Flow cytometry; MPP+; MPTP; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; LACTIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

APOPTOSIS; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENETIC DISORDER; HUMAN; HUMAN CELL; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; TRANSGENE;

1-METHYL-4-PHENYLPYRIDINIUM; APOPTOSIS; CELL CYCLE; CELL MEMBRANE; CELL NUCLEUS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; FLOW CYTOMETRY; FLUORESCEINS; HUMANS; LACTIC ACID; MEMBRANE POTENTIALS; MICROSCOPY, ELECTRON, SCANNING; MITOCHONDRIA; NAD(P)H DEHYDROGENASE (QUINONE); NEUROBLASTOMA; NEURONS; REACTIVE OXYGEN SPECIES; RHODAMINES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0033104442     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990301)55:5<620::AID-JNR9>3.0.CO;2-S     Document Type: Article

References (48)

1. Adams JD, Klaidman LK, Cadenas E. 1992. MPP+ redox cycling: a new mechanism involving hydride transfer. Ann NY Acad Sci 648:239-240.
2. Adams JD, Jr, Klaidman LK, Leung AC. 1993. MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes. Free Rad Biol Med 15:181-186.
3. Ali SF, David SN, Newport GD, Cadet JL, Slikker W, Jr. 1994. MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels. Synapse 18:27-34.
4. Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J, Mouatt-Prigent A, Ruberg M, Hirsch EC, Agid Y. 1997. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Hist Histopathol 12:25-31.
5. Ballard PA, Tetrud JW, Langston JW. 1985. Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology 35:949-956.
6. Basma AN, Heikkila RE, Saporito MS, Philbert M, Geller HM, Nicklas WJ. 1992. 1-Methyl-4-(2′-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells is enhanced by preventing glycolysis. J Neurochem 58:1052-1059.
7. Beal MF. 1995. Aging, energy and oxidative-stress in neurodegenerative diseases. Annal Neurol 38:357-366.
8. Beal MF, Hyman BT, Koroshetz W. 1993. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? [see comments]. Trends Neurosci 16:125-131.
9. Biedler JL, Roffler-Tarlov S, Schachner M, Freedman LS. 1978. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res 38:3751-3757.
10. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. 1995. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166.
11. Boobis AR, Fawthrop DJ, Davies DS. 1990. Mechanisms of cell toxicity. Curr Op Cell Biol 2:231-237.
12. Buck KJ, Amara SG. 1994. Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium. Proc Natl Acad Sci USA 91:12584-12588.
13. Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ. 1983. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 80:4546-4550.
14. Cassarino CS, Fall CP, Swerdlow RH, Smith TS, Halvorsen EM, Miller SW, Parks JP, Parker WD, Jr, Bennett JP Jr. 1997. Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of parkinson's disease. Biochem Biophys Acta (in press).
15. Cassarino DS, Fall CP, Smith TS, Bennett JP, Jr. 1998. Pramipexole reduces reactive oxygen species production in vivo and in vitro and inhibits the mitochondrial permeability transition produced by the parkinsonian neurotoxin methylpyridinium ion. J Neurochem 71:295-301.
16. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F. 1997. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 27:1-20.
17. Dipasquale B, Marini AM, Youle RJ. 1991. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem Biophys Res Commun 181:1442-1448.
18. Farooqui SM. 1994. Induction of adenylate cyclase sensitive dopamine D2-receptors in retinoic acid induced differentiated human neuroblastoma SHSY-5Y cells. Life Sci 55:1887-1893.
19. Gong J, Traganos F, Darzynkiewicz Z. 1994. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 218:314-319.
20. Greenlund LJ, Deckwerth TL, Johnson EM, Jr. 1995. Superoxide dismutasc delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14:303-315.
21. Jacobson MD, Burne JF, King MP, Miyashita T, Reed JC, Raff MC. 1993. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361:365-369.
22. King MP, Attardi G. 1989. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 246:500-503.
23. Langston JW, Irwin I, Langston EB, Forno LS. 1984. 1-methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci Lett 48:87-92.
24. Marchetti P, Susin SA, Decaudin D, Gamen S, Castedo M, Hirsch T, Zamzami N, Naval J, Senik A, Kroemer G. 1996. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA. Cancer Res 56:2033-2038.
25. Mochizuki H, Nakamura N, Nishi K, Mizuno Y. 1994. Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat. Neurosci Lett 170:191-194.
26. Mochizuki H, Mori H, Mizuno Y. 1997. Apoptosis in neurodegenerative disorders. J Neural Trans (Suppl) 50:125-140.
27. Moratalla R, Quinn B, DeLanney LE, Irwin I, Langston JW, Graybiel AM. 1992. Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 89:3859-3863.
28. Nicklas WJ, Vyas I, Heikkila RE. 1985. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 36:2503-2508.
29. Pifl C, Giros B, Caron MG. 1993. Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. J Neurosci 13:4246-4253.
30. Ramsay RR, Krueger MJ, Youngster SK, Gluck MR, Casida JE, Singer TP. 1991a. Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase. J Neurochem 56:1184-1190.
31. Ramsay RR, Krueger MJ, Youngster SK, Singer TP. 1991b. Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP+) and of the respiratory chain inhibitor piericidin A are the same. Biochem J 273:481-484.
32. Rao KM, Padmanabhan J, Kilby DL, Cohen HJ, Currie MS, Weinberg JB. 1992. Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor. J Leukocyte Biol 51:496-500.
33. Ratan RR, Murphy TH, Baraban JM. 1994. Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem 62:376-379.
34. Richards ML, Sadee W. 1986. Human neuroblastoma cell lines as models of catechol uptake. Brain Res 384:132-137.
35. Royall JA, Ischiropoulos H. 1993. Evaluation of 2′,7′-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Arch Biochem Biophys 302:348-355.
36. Schapira AH. 1994. Evidence for mitochondrial dysfunction in Parkinson's disease - a critical appraisal. Movement Dis 9:125-138.
37. Stewart BW. 1994. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 86:1286-1296.
38. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP, Davis RE, Parker WD. 1996. Origin and functional consequences of the complex 1 defect in Parkinsons disease. Ann Neurol 40:663-671.
39. Thiffault C, Aumont N, Quirion R, Poirier J. 1995. Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain. J Neurochem 65:2725-2733.
40. Tipton KF, Singer TP. 1993. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem 61:1191-1206.
41. Vayssiere JL, Petit PX, Risler Y, Mignotte B. 1994. Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40. Proc Natl Acad Sci USA 91:11752-11756.
42. Zahrebelski G, Nieminen AL, al-Ghoul K, Qian T, Herman B, Lemasters JJ. 1995. Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study. Hepatology 21:1361-1372.
43. Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B, Kroemer G. 1995a. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182:367-377.
44. Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssiere JL, Petit PX, Kroemer G. 1995b. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med 181:1661-1672.
45. Zamzami N, Susin SA, Marchetti P, Hirsch T, Gomez-Monterrey I, Castedo M, Guido K. 1996. Mitochondrial control of nuclear apoptosis [see comments]. J Exp Med 183:1533-1544.
46. Zhu H, Bannenberg GL, Moldeus P, Shertzer HG. 1994. Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescein. Arch Toxicol 68:582-587.
47. Ziv I, Melamed E, Nardi N, Luria D, Achiron A, Offen D, Barzilai A. 1994. Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons - a possible novel pathogenetic mechanism in Parkinson's disease. Neurosci Lett 170:136-140.
48. Zoratti M, Szabo I. 1995. The mitochondrial permeability transition. Biochim Biophys Acta 1241:139-176.