Chloromethyltetramethylrosamine (Mitotracker Orange™) induces the mitochondrial permeability transition and inhibits respiratory complex I: Implications for the mechanism of cytochrome c release

Journal of Biological Chemistry

Volumn 274, Issue 35, 1999, Pages 24657-24663

  Scorrano, Luca ^a   Petronilli, Valeria ^a   Colonna, Raffaele ^a   Di Lisa, Fabio ^a   Bernardi, Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; THIOL DERIVATIVE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; ENZYME RELEASE; FLUORESCENCE; MEMBRANE BINDING; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

ANIMALS; ARSENICALS; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CELL LINE; CYTOCHROME C GROUP; ELECTRON TRANSPORT COMPLEX I; ETHYLMALEIMIDE; FLUORESCENT DYES; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; NADH, NADPH OXIDOREDUCTASES; PERMEABILITY; RATS; RATS, WISTAR; RHODAMINES; XANTHENES;

ANIMALIA;

EID: 0033609791     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.35.24657     Document Type: Article

References (29)

1. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. (1996) Cell 86, 147-157
2. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T. I., Jones, D. P., and Wang, X. (1997) Science 275, 1129-1132
3. Susin, S. A., Zamzami, N., Castedo, M., Hirsch, T., Marchetti, P., Macho, A., Daugas, E., Geuskens, M., and Kroemer, G. (1996) J. Exp. Med. 184, 1331-1341
4. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D. R., Aebersold, R., Siderovski, D. P., Penninger, J. M., and Kroemer, G. (1999) Nature 397, 441-446
5. Bernardi, P., Scorrano, L., Colonna, R., Petronilli, V., and Di Lisa F. (1999) Eur. J. Biochem., in press
6. Cai, J., Yang, J., and Jones, D. P. (1998) Biochim. Biophys. Acta 1366, 139-149
7. Susin, S. A., Zamzami, N., and Kroemer, G. (1998) Biochim. Biophys. Acta 1366, 151-165
8. Bernardi, P., Broekemeier, K. M., and Pfeiffer, D. R. (1994) J. Bioenerg. Biomembr. 26, 509-517
9. Gunter, T. E., Gunter, K. K., Sheu, S. S., and Gavin, C. E. (1994) Am. J. Physiol. 267, C313-C339
10. Zoratti, M., and Szabo, I. (1995) Biochim. Biophys. Acta 1241, 139-176
11. Bernardi, P. (1999) Physiol. Rev. 79, in press
12. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. (1997) Science 275, 1132-1136
13. Pastorino, J. G., Chen, S. T., Tafani, M., Snyder, J. W., and Farber, J. L. (1998) J. Biol. Chem. 273, 7770-7775
14. Bradham, C. A., Qian, T., Streetz, K., Trautwein, C., Brenner, D. A., and Lemasters, J. J. (1998) Mol. Cell. Biol. 18, 6353-6364
15. Li, H., Zhu, H., Xu, C. J., and Yuan, J. (1998) Cell 94, 491-501
16. Bossy-Wetzel, E., Newmeyer, D. D., and Green, D. R. (1998) EMBO J. 17, 37-49
17. Eskes, R., Antonsson, B., Osen-Sand A., Montessuit, S., Richter, C., Sadoul, R., Mazzei, G., Nichols, A., and Martinou, J.-C. (1998) J. Cell Biol. 143, 217-224
18. Heiskanen, K. M., Bhat, M. B., Wang, H.-W., Ma, J., and Nieminen, A-L. (1999) J. Biol. Chem. 274, 5654-5658
19. Finucane, D. M., Bossy-Wetzel, E., Waterhouse, N. J., Cotter, T. G., and Green, D. R. (1999) J. Biol. Chem. 274, 2225-2233
20. Rottenberg, H., and Wu, S. (1998) Biochim. Biophys. Acta 1404, 393-404
21. Macho, A., Decaudin, D., Castedo, M., Hirsch, T., Susin, S. A., Zamzami, N., and Kroemer, G. (1996) Cytometry 25, 333-340
22. Costantini, P., Petronilli, V., Colonna, R., and Bernardi, P. (1995) Toxicology 99, 77-88
23. Igbavboa, U., and Pfeiffer, D. R. (1988) J. Biol. Chem. 263, 1405-1412
24. Fontaine, E., Eriksson, O., Ichas, F., and Bernardi, P. (1998) J. Biol. Chem. 273, 12662-12668
25. Fontaine, E., Ichas, F., and Bernardi, P. (1998) J. Biol. Chem. 273, 25734-25740
26. Bernardi, P. (1992) J. Biol. Chem. 267, 8834-8839
27. Wadia, J. S., Chalmers-Redman, R. M. E., Ju, W. J. H., Carlile, G. W., Phillips, J. L., Fraser, A. D., and Tatton, W. G. (1998) J. Neurosci. 18, 932-947
28. Loew, L. M., Tuft, R. A., Carrington, W., and Fay, F. S. (1993) Biophys. J. 65, 2396-2407
29. Adachi, S., Gottlieb, R. A., and Babior, B. M. (1998) J. Biol. Chem. 273, 19892-19894