Growth-inhibitory effects of the synthetic retinoid CD437 against ovarian carcinoma models in vitro and in vivo

Cancer Chemotherapy and Pharmacology

Volumn 42, Issue 5, 1998, Pages 429-432

  Langdon, Simon P ^a   Rabiasz, Genevieve J ^a   Ritchie, Alison A ^a   Reichert, Uwe ^b   Buchan, Peter ^b   Miller, William R ^a   Smyth, John F ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b Ctr Intl de Rech Dermatologigues   (France)

Author keywords

CD437; Ovarian cancer; Retinoid; Xenograft

Indexed keywords

6 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 2 NAPHTHOIC ACID; RETINOID; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; OVARY CARCINOMA; PRIORITY JOURNAL; TUMOR CELL LINE; XENOGRAFT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA; CELL DIVISION; CISPLATIN; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; RETINOIDS; TUMOR CELLS, CULTURED;

EID: 0031716244     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050841     Document Type: Article

References (21)

1. Smith MA, Parkinson DR, Cheson BD, Friedman MA (1992) Retinoids in cancer therapy. J Clin Oncol 10: 839
2. Langdon SP, Hawkes MM, Hay FG, Lawrie SS, Schol DJ, Hilgers J, Leonard RCF, Smyth JF (1998) Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines. Cancer Res 48: 6161
3. Caliaro MJ, Marmouget C, Guichard S, Mazars P, Valette A, Moisand A, Bugat R, Jozan S (1994) Response of four human ovarian carcinoma cell lines to all-trans rctinoic acid: relationship with induction of differentiation and retinoic acid receptor expression. Int J Cancer 56: 743
4. Harant H, Korschineck I, Krupitza G, Fazeny B, Dittrich C, Grunt TW (1993) Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription. Br J Cancer 68: 530
5. Grunt TW, Somay C, Oeller H, Dittrich E, Dittrich C (1992) Comparative analysis of the effects of dimethyl sulfoxide and retinoic acid on the antigenic pattern of human ovarian adenocarcinoma cells. J Cell Sci 103: 501
6. Somay C, Grunt TW, Mannhalter C, Dittrich C (1992) Relationship of myc protein expression to the phenotype and to the growth potential of HOC-7 ovarian cancer cells. Br J Cancer 66: 93
7. Brooks SE, Timmerman J, Lau CC, Tsao SW, Knapp RC, Sheets EE (1991) Effect of differentiation agents on expression of CA 125, alkaline phosphatase, and cytokeratins in human ovarian adenocarcinoma cells (OVCA 433). Gynecol Oncol 42: 265
8. Grunt TW, Somay C, Pavelka M, Ellinger A, Dittrich E, Dittrich C (1991) The effects of dimethyl sulfoxide and retinoic acid on the cell growth and the phenotype of ovarian cancer cells. J Cell Sci 100: 657
9. Formelli F, Cleris L (1993) Synthetic retinoid fenretinide is effective against a human ovarian carcinoma xenograft and potentiates cisplatin activity. Cancer Res 53: 5374
10. Kastner P, Mark M, Chambon P (1995) Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83: 859
11. Mangelsdorf D, Evans R (1995) The RXR heterodimers and orphan receptors. Cell 83: 841
12. Bernard BA, Bernadon JM, Delescluse C, Martin B, Lenoir MC, Maignan J, Charpentier B, Pilgrim WR, Reichert U, Shroot B (1992) Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochem Biophys Res Commun 186: 977
13. WAF1 CIP1 expression in human breast carcinoma cells. Cancer Res 56: 5055
14. Hsu CA, Rishi AK, Li S-X, Gerald TM, Dawson MI, Schiffer C, Reichert U, Shroot B, Poirer GC, Fontana JA (1997) Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway. Blood 89: 4470
15. Hsu CK, Rishi AK, Li X-S, Dawson MI, Reichert U, Shroot B, Fontana JA (1997) Bcl-X(L) expression and its down-regulation by a novel retinoid in breast carcinoma cells. Exp Cell Res 232: 17
16. Schadendorf D, Kern MA, Artuc M, Pahl HL, Rosenbach T, Fichtner I, Nurnberg W, Stuting S, Stebut E, Worm M, Makki A, Jurgovsky K, Kolde G, Henz BM (1996) Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro and causes growth inhibition in xenografts in vivo. J Cell Biol 135: 1889
17. Schandendorf D, Worm M, Jurgovsky K, Dippel E, Reichert U, Czarnetzki BM (1995) Effects of various synthetic retinoids on proliferation and immunophenotype of human melanoma cells in vitro. Recent Results Cancer Res 139: 183
18. Sun S-Y, Yue P, Dawson MI, Shroot B, Michel S, Lamph WW, Heyman RA, Teng M, Chandraratna RAS, Shudo K, Hong WK, Lotan R (1997) Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res 57: 4931
19. Langdon SP, Lawrie SS, Hay FG, Hawkes MM, McDonald A, Hayward JP, Schol DJ, Hilgers J, Leonard RCF, Smyth JF (1998) Characterisation and properties of nine human ovarian adenocarcinoma cell lines. Cancer Res 48: 6166
20. Langdon SP, Ritchie A, Young K, Crew AJ, Sweeting V, Bramley T, Hillier S, Hawkins RA, Tesdale AL, Smyth JF, Miller WR (1993) Contrasting effects of 17 β-estradiol on the growth of human ovarian carcinoma cells in vitro and in vivo. Int J Cancer 55: 459
21. Sun S-Y, Yue P, Shroot B, Hong W-K, Lotan R (1997) Induction of apoptosis in human non small cell lung carcinoma cells by the novel synthetic retinoid CD437. J Cell Physiol 173: 279