Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo

Journal of Cell Biology

Volumn 135, Issue 6 II, 1996, Pages 1889-1898

  Schadendorf, Dirk ^a   Kern, Monika A ^a   Artuc, Metin ^a   Pahl, Heike L ^b   Rosenbach, Thomas ^a   Fichtner, Iduna ^c   Nürnberg, Wolf ^a   Stüting, Sabine ^a   Stebut, Esther V ^a   Worm, Margitta ^a   Makki, Amira ^a   Jurgovsky, Klaus ^a   Kolde, Gert ^a   Henz, Beate M ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; DIGOXIGENIN; DNA FRAGMENT; RETINOID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; MELANOMA CELL; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA FRAGMENTATION; GROWTH INHIBITORS; HUMANS; MALE; MELANOMA; MICE; MICE, NUDE; MICROSCOPY, ELECTRON; NEOPLASM TRANSPLANTATION; RETINOIDS; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 12644302209     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.6.1889     Document Type: Article

References (49)

1. Alles, A.J., and K.K. Sulik. 1990. Retinoic acid-induced spina bifida: evidence for a pathogenic mechanism. Development (Camb.). 108:73-81.
2. Apfel, C., M. Crettaz, G. Siegenthaler, and W. Hunziker. 1991. Synthetic retinoids: differential binding to retinoic acid receptors. In Retinoids: 10 Years On. J.-H. Saurat, editor. Karger, Basel. 110-120.
3. Artuc, M., W. Nürnberg, B.M. Czarnetzki, and D. Schadendorf. 1995. Characterization of gene regulatory elements for selective gene expression in human melanoma cells. Biochem. Biophys. Res. Commun. 213:699-704.
4. Auwerx, J., and P. Sassone-Corsi. 1992. AP-1 (Fos-Jun) regulation by IP-1: effect of signal transduction pathways and cell growth. Oncogene. 7:2271-2280.
5. Baker, S.J., S. Markowitz, E.R. Fearon, J.K.V. Willson, and B. Vogelstein. 1990. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (Wash. DC). 249:912-915.
6. Bernard, B.A., J.M. Bernadon, C. Delescluse, B. Martin, M.C. Lenoir, J. Maignan, B. Charpentier, W.R. Pilgrim, U. Reichert, and B. Shroot. 1992. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochem. Biophys. Res. Commun. 186:977-983.
7. Bollag, W., and E.E. Holdener. 1992. Retinoids in cancer prevention and therapy. Annu. Oncol. 5:515-526.
8. Buttyan, R., Z. Zaderi, R. Lockshin, and D. Wohlmuth. 1988. Cascade induction of c-fos. c-myc, and heat shock 70k transcripts during regression of the rat ventral prostate gland. Mol. Endocrinol. 2:650-657.
9. Chen, J.-Y., S. Penco, J. Ostrowski, P. Balaguer, M. Pons, J.E. Starrett, P. Reczek, P. Chambon, and H. Gronemeyer. 1995. RAR-specific agonist/antagonists which dissociate transactivation and AP-1 transrepression inhibit anchorage-independent cell proliferation. EMBO (Eur. Mol. Biol. Organ.) J. 14:1187-1197.
10. Chen, S.C., T. Curran, and J.L. Morgan. 1995. Apoptosis in the nervous system: new revelations. J. Clin. Pathol. 48:7-12.
11. Colotta, F., N. Polentarutti, M. Sironi, and A. Mantovani. 1992. Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J. Biol. Chem. 267: 18278-18283.
12. Devary, Y., R.A. Gottlieb, L.F. Lau, and M. Karin. 1991. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell. Biol. 11:2804-2811.
13. Engelberg, D., C. Klein, H. Martinetto, K. Struhl, and M. Karin. 1994. The UV response involving the RAS signalling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell. 77:381-390.
14. Eslus, S., W.J. Zaks, R.S. Freeman, M. Gruda, R. Bravo, and E.M. Johnson. 1994. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell. Biol. 127: 1717-1727.
15. Evans, R. 1988. The steroid and thyroid hormone superfamily. Science (Wash. DC). 240:889-895.
16. Fanjul, A., M.I. Dawson, P.D. Hobbs, L. Jong, J.F. Cameron, E. Harlev, G. Graupner, X.P. Lu, and M. Pfahl. 1994. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature (Lond.). 372:107-110.
17. Hagmeyer, B.M., P. Angel, and H. van Dam. 1995. Modulation of AP-1/ATF transcription factor activity by the adenovirus-E1A oncogene products. BioEssays. 17:621-629.
18. Ho, V.C., and A.J. Sober. 1990. Therapy of cutaneous melanoma: an update. J. Am. Acad. Dermatol. 22:159-176.
19. Hoal, E., E.L. Wilson, and L.J. Dowdle. 1982. Variable effects of retinoids on two pigmented human melanoma cell lines. Cancer Res. 42:5191-5195.
20. Horie, M., and H.E. Broxmeyer. 1995. The combination of steel factor and GM-CSF blocks apoptosis induced by retinoic acid and upregulates AP-1 in a human growth factor-dependent cell line. Exp. Hematol. 23:168-173.
21. Hughes, P., and M. Dragunow. 1995. Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol. Rev. 47:133-178.
22. Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S.-C. Lin, R.A. Heyman, D.W. Rose, C.K. Glass, and M.G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 85:403-414.
23. Kastner, P.. M. Mark, and P. Chambon. 1995. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life. Cell. 83:859-869.
24. Kolde, G., and J. Knop. 1986. Ultrastructural morphometry of epidermal Langerhans cells: introduction of a simple method for a comprehensive quantitative analysis of the cells. Arch. Dermatol. Res. 278:298-301.
25. Kurie, J.M.,S.M. Lippman, and W.K. Hong. 1994. Potential of retinoids in cancer prevention. Cancer Treat. Rev. 20:1-10.
26. Li, J.-J., Z, Dong, M. Dawson, and N.H. Colburn. 1996. Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element. Cancer Res. 56:483-489.
27. Lotan, R. 1980. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim. Biophys. Acta. 605:33-91.
28. Lotan, R., M.J.C. Hendrix, and S.M. Lippman. 1991. Retinoids in the management of melanoma. In Retinoids in Cutaneous Malignancy. R. Marks, editor. Blackwell. 133-149.
29. Mangelsdorf, D., and R. Evans. 1995. The RXR heterodimers and orphan receptors. Cell. 83:841-850.
30. Marti, A., B. Jehn, E. Costello, N. Keon, G. Ke, F. Martin, and R. Jaggi. 1994. Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells. Oncogene. 9:1213-1223.
31. Martin. S.J.. and D.R. Green. 1994. Apoptosis as a goal of cancer therapy. Curr. Opin. Oncol. 6:616-621.
32. Meyskens, F.L., Jr., and B. Fuller. 1980. Characterization of different retinoids on the growth and differentiation of a human melanoma cell line and selected subclones. Cancer Res. 40:2194-2196.
33. Nürnberg, W., M. Artuc, G. Vorbrueggen, F. Kalkbrenner, K. Mölling, B.M. Czarnetzki, and D. Schadendorf. 1995. Nuclear proto-oncogenes transactivate the HPV-16 promotor. Brit. J. Cancer. 71:1018-1024.
34. Pahl, H.L., and P. Baeuerle. 1995. A novel signal transduction pathway between the endoplasmatic reticulum and the nucleus is mediated by transcriptionfactor NF-κb. EMBO (Eur. Mol. Biol. Organ.) J. 14:2550-2558.
35. Pfahl, M. 1993. Nuclear receptor/AP-1 interaction. Endocr. Rev. 14:651-658.
36. Piechaczyk, M., and J.-M. Blanchard. 1994. c-fos proto-oncogene regulation and function. Crit. Rev. Oncol. Hematol. 17:93-131.
37. Piacentini, M., L. Fesus, M.G. Farrace, L. Ghibelli, L. Piredda, and G. Melino. 1991. The expression of "tissue" transglutaminase in two human cancer cell lines is related with the programmed cell death (apoptosis). Eur. J. Cell Biol. 54:246-254.
38. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
39. Schadendorf, D., A. Möller, B. Algermissen, M. Worm, M. Sticherling, and B.M. Czarnetzki. 1993. IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. J. Immunol. 151:2667-2675.
40. Schadendorf, D., M. Worm, K. Jurgovsky, E. Dippel, S. Michel, B. Charpentier. J.M. Bernardon, U. Reichert, and B.M. Czarnetzki. 1994. Retinoic acid receptor-γ-selective retinoids exert antiproliferative effects on human melanoma cell growth in vitro. Int. J Oncol. 5:1325-1331.
41. Schadendorf, D., A. Makki, C. Stahr, A. van Dyck, R. Wanner, G.L. Schcffer, M.J. Flens, R. Scheper, and B.M. Henz. 1995. Membrane transport proteins associated with drug resistance expressed in human melanoma. Am. J. Pathol. 147:1545-1552.
42. Schreiber, M., B. Baumann, M. Cotten, P. Angel, and E.F. Wagner. 1995. Fos is an essential component of the mammalian UV response. EMBO (Eur. Mol. Biol. Organ.) J. 14:5338-5349.
43. Schule, R., P. Rangarajan, S. Kliewer, L.J. Ransone, N. Yang, I.M. Verma, and R.M. Evans. 1990. Functional antagonism between oncoprotein c-jun and the glucocorticoid receptor. Cell. 62:1217-1226.
44. Schüle, R., P. Rangarajan, N. Yang, S. Kliewer, L.J. Ransone, J. Bolado, I.M. Verma, and R.M. Evans. 1991. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc. Natl. Acad. Sci. USA. 88:6092-6096.
45. 1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene. 11:493-504.
46. Smeyne, R.J., M. Vendrell, M. Hayward, S.J. Baker, G.G. Miao, K. Schilling, L.M. Robertson, T. Curran, and J.L. Morgan. 1993. Continuous c-fos expression precedes programmed cell death in vivo. Nature (Lond.). 363:166-169.
47. Smith, M.A., D.R. Parkinson, B.D. Cheson, and M.A. Friedman. 1992. Retinoids in cancer therapy. J. Clin. Oncol. 10:839-864.
48. Trede, N.S., R.S. Geha, and T. Chatila. 1991. Transcnptional activation of IL-1β and tumor necrosis factor alpha genes by MHC class II genes. J. Immunol. 146:2310-2315.
49. Yang-Yen, H.F., X.K. Zhang, G. Graupner, M. Tzukerman, B. Sakamoto, M. Karin, and M. Pfahl. 1991. Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. New Biol. 3: 1206-1219.