The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2- naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases

Blood

Volumn 93, Issue 3, 1999, Pages 1045-1061

  Mologni, Luca ^b   Ponzanelli, Isabella ^b   Bresciani, Filippo ^b   Sardiello, Gabriele ^b   Bergamaschi, Daniele ^b   Gianní, Maurizio ^b   Reichert, Uwe ^b   Rambaldi, Alessandro ^b   Terao, Mineko ^b   Garattini, Enrico ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 7 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 3 PROPOXY 2 NAPHTHYL) 2,4,6 OCTATRIENOIC ACID; 4 [2 [5,6 DIHYDRO 5,5 DIMETHYL 8 (4 METHYLPHENYL) 2 NAPHTHYL]ETHYNYL]BENZOIC ACID; 4 [7 ADAMANTYL 6 [(2 METHOXYETHOXY)METHOXY] 2 NAPHTHYL]BENZOIC ACID; 6 (3 ADAMANTYL 4 HYDROXYPHENYL) 2 NAPHTHALENE CARBOXYLIC ACID; 6 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 2 NAPHTHOIC ACID; CASPASE; CD 2325; CD 2781; CD 3106; CD 3159; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; UNCLASSIFIED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CONTROLLED STUDY; DNA DEGRADATION; DNA SEQUENCE; DRUG EFFICACY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

EID: 0032906263     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.3.1045     Document Type: Article

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