Activity of Retinoic acid receptor-γ selectively binding retinoids alone and in combination with interferon-γ in breast cancer cell lines

International Journal of Cancer

Volumn 71, Issue 3, 1997, Pages 497-503

  Widschwendter, Martin ^a   Daxenbichler, Günter ^a   Culig, Zoran ^b   Michel, Serge ^c   Zeimet, Alain G ^a   Mörtl, Manfred G ^a   Widschwendter, Andreas ^a   Marth, Christian ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c Galderma R and D   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; RETINOIC ACID; RETINOIC ACID BINDING PROTEIN; RETINOIC ACID RECEPTOR;

ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SAFETY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; TRANSACTIVATION;

EID: 0030996039     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970502)71:3<497::AID-IJC31>3.0.CO;2-A     Document Type: Article

References (25)

1. BERENBAUM, M.C., Criteria for analyzing interactions between biologically active agents, Adv. Cancer Res., 35, 269-335 (1981).
2. BERNARD, B.A., BERNARDON, J.-M. DELESCLUSE, C., MARTIN. B., LENOIR, M.-C., MAIGNAN, J., CHARPENTIER, B., PILGRIM, W.R., REICHERT, U. and SHROOT, B., Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Bioch. biophys. Res. Comm., 186, 977-983 (1992).
3. BOYLAN, J.F., LOHNES, D., TANEJA, R., CHAMBON, P. and GUDAS, L.J., Loss of retinoic acid receptor γ function in F9 cells by gene disruption results in aberrant Hoxa-l expression and differentiation upon retinoic acid treatment. Proc. nat. Acad. Sci. (Wash.), 90, 9601-9605 (1993).
4. CHOU, T.C. and TALALAY, P., Quantitative analysis of dose-effect relationships: the combined effect of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul., 22, 27-54 (1984).
5. DAWSON, M.I., CHAO, W., PINE, P., JONG, L., HOBBS, P.D., RUDD, C.K., QUICK, T.C., NILES, R.M., ZHANG, X., LOMBARDO, A., ELY, K.R., SHROOT, B. and FONTANA, J.A., Correlation of retinoid binding affinity to retinoic acid receptor α with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells. Cancer Res., 55, 4446-4451 (1995).
6. DE CREMOUX, P., GAUVILLE, C., CLOSSON, V., LINARES, G., CALVO, F., TAVITIAN, A. and OLOFSSON, B., EGF modulation of the ras-related rhoB gene expression in human breast-cancer cell lines. Int. J. Cancer. 59, 408-415 (1994).
7. DELESCLUSE, C., CAVEY, M.T., MARTIN. B., BERNARD. B.A., REICHERT, U., MAIGNAN, J., DARMON, M. and SHROOT. B., Selective high affinity retinoic acid receptor a or ß-γ ligands. Mol. Pharmacol., 40, 556-562 (1991).
8. DURAND, B., SAUNDERS, M., LEROY, P., LEID, M. and CHAMBON, P., All-trans and 9-cis retinoic acid induction of CRABP II transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs. Cell, 71, 73-85 (1992).
9. FANJUL, A.N., BOUTERFA, H., DAWSON, M. and PFAHL, M., Potential role for retinoic acid receptor-γ in the inhibition of breast cancer cells by selective retinoids and interferons. Cancer Res., 56, 1571-1577 (1996).
10. FANJUL, A., DAWSON, M.I., HOBBS, P.D., JONG, L., CAMERON, J.F., HARLEY, E., GRAUPNER, G., Lu, X.-P. and PFAHL, M., A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature (Lond.), 372, 107-111(1994).
11. JONAT, C., RAHMSDORF, H.J., PARK. K.-K., CATO, A.C.B., GEBEL, S., PONTA, H. and HERRLICH, P., Antitumor promotion and antiinflammation: down modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62, 1189-1204 (1990).
12. KENNEDY, M.J., PRESTIGIACOMO, L.J., TYLER, G., MAY, W.S. and DAVIDSON, N.E., Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines. Cancer Res., 52, 1278-1283 (1992).
13. Liu, Y., LEE, M.-O., WANG, H.-G., Li, Y., HASHIMOTO, Y. KLAUS, M., REED, J.C. and ZHANG, X.-K., Retinoic acid receptor b mediates the growth- inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol. Cell Biol., 16, 1138-1149(1996).
14. MARSHALL, G.M., CHEUNG, B., STACEY,. K.P., CAMACHO, M.L., SIMPSON, A.M., KWAN, E., SMITH, S., HABER, M. and NORRIS, M.D., Increased retinoic acid receptor gamma expression suppresses the malignant phenotype and alters the differentiation potential of human neuroblastoma cells. Oncogene, 11, 485-491 (1995).
15. MARTH, C., DAXENBICHLER, G. and DAPUNT, O., Synergistic antiproliferative effect of human recombinant interferons and retinoic acid in cultured breast cancer cells. J. nat. Cancer, Inst., 77, 1197-1202(1986).
16. MARTH, C., WIDSCHWENDTER, M. and DAXENBICHLHER, G., Mechanism of synergistic action of all-trans- or 9-cis-retinoic acid and interferons in breast cancer cells. J. Steroid biochem. mol. Biol., 47, 123-126 (1993).
17. MOASSER, M.M., DE BLASIO, A. and DIMITROVSKY, E., Response and resistance to retinoic acid are mediated through the retinoic acid nuclear receptor gamma in human teratocarcinomas. Oncogene, 9, 833-840 (1994).
18. RECCHIA, F., SICA, G., DE FILIPPIS, S., DISCEPOLI, S., REA, S., TORCHIO, P. and FRATI, L., Interferon-β, retinoids, and tamoxifen in the treatment of metastatic breast cancer: a phase II study. J. Interferon Cytokine Rex., 15, 605-610 (1995).
19. SCHADENDORF, D., WORM, M., JURGOVSKY, K., DIPPEL, E., MICHEL, S., CHARPENTIER, B., BERNARDON, J.-M., REICHERT, U. and CARNETZKI, B.M., Retinoic acid receptor-γ-selective retinoids exen antiproliferative effects on human melanoma cell growth in vitro. Int. J. Oncol., 5, 1325-1331 (1994).
20. 1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene. 11, 493-504 (1995).
21. SPORN, M.B., ROBERTS, A.B. and GOODMAN, D.S., The retinoids: biology, chemistry and medicine (2nd ed.), Raven Press, New York (1994).
22. TANEJA, R., BOUILET, P., BOYLAN, J.F., GAUB, M.-P., ROY, B., GUDAS, L.J. and CHAMBON, P., Reexpression of retinoic acid receptor (RAR)γ or overexpression of RARαa or RARβ in RARγ-null F9 cells reveals a partial functional redundancy between the three RAR types. Proc. nat. Acad, Sci, (Wash.) 92, 7854-7858 (1995).
23. VAN DER BURG, B., SLAGER-DAVIDOV, R., VAN DER LEEDE, B.M., DE LAAT, S.W. and VAN DER SAAG, P.T., Differential regulation of API activity by retinoic acid in hormone-dependent and -independent breast cancer cells. Mol. cell. Endocrinol., 112, 143-152 (1995).
24. WIDSCHWENDTER, M., DAXENBICHLER, G., DAPUNT, O. and MARTH, C., Effects of retinoic acid and γ-interferon on expression of retinoic acid receptor and cellular retinoic acid-binding protein in breast cancer cells. Cancer Res., 55, 2135-2139 (1995).
25. WIDSCHWENDTER, M., DAXENBICHLER, G., BACHMAIR, F., MÜ LLER, E., ZEIMET, A.C., WINDBICHLER, G., UHL-STEIDL, M., LANG, T. and MARTH, C., Interaction of retinoic acid and interferon-α in breast cancer cell lines. Anticancer Res., 16, 369-374 (1996).