Alternative ribonucleic acid processing in endocrine systems

Endocrine Reviews

Volumn 22, Issue 2, 2001, Pages 205-225

  Lou, Hua ^a   Gagel, Robert F ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; GROWTH HORMONE; MESSENGER RNA; RNA;

ALTERNATIVE RNA SPLICING; DROSOPHILA; GENE CONTROL; HORMONE ACTION; PRIORITY JOURNAL; REVIEW; RNA PROCESSING; SEQUENCE ANALYSIS; SPERMATOGENESIS;

EID: 0035015344     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/edrv.22.2.0426     Document Type: Review

References (171)

1. 1. Missler M, Sudhof TC 1998 Neurexins: three genes and 1001 products. Trends Genet 14:20-26
2. 2. Hanke J, Brett D, Zastrow I, Aydin A, Delbruck S, Lehmann G, Luft F, Reich J, Bork P 1999 Alternative splicing of human genes: more the rule than the exception? Trends Genet 15:389-390
3. 3. Thanaraj TA 1999 A clean dataset of EST-confirmed splice sites from Homo sapiens and standards for clean-up procedures. Nucleic Acids Res 27:2627-2637
4. 4. Croft L, Schandorff S, Clark F, Burrage K, Arctander P, Mattick JS 2000 ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome. Nat Genet 24:340-341
5. 5. Smith CW, Patton JG, Nadal-Ginard B 1989 Alternative splicing in the control of gene expression. Annu Rev Genet 23:527-577
6. 6. Black D 1998 Splicing in the inner ear: a familiar tune, but what are the instruments? Neuron 20:165-168
7. 7. Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM 1982 Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298: 240-244
8. 8. Rosenfeld MG, Amara SG, Evans RM 1984 Alternative RNA processing: determining neuronal phenotype. Science 225:1315-1320
9. 9. Ruppert S, Cole TJ, Boshart M, Schmid E, Schutz G 1992 Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J 11:1503-1512
10. 10. Foulkes NS, Mellstrom B, Benusiglio E, Sassone-Corsi P 1992 Developmental switch of CREM function during spermatogenesis: from antagonist to activator. Nature 355:80-84
11. 11. Gervois P, Torra IP, Chinetti G, Grotzinger T, Dubois G, Fruchart JC, Fruchart-Najib J, Leitersdorf E, Staels B 1999 A truncated human peroxisome proliferator-activated receptor α splice variant with dominant negative activity. Mol Endocrinol 13:1535-1549
12. 12. Wang J, Manley JL 1997 Regulation of pre-mRNA splicing in metazoa. Curr Opin Genet Dev 7:205-211
13. 13. Rio DC 1993 Splicing of pre-mRNA: mechanism, regulation and role in development. Curr Opin Genet Dev 3:574-584
14. 14. Wang A, Cohen DS, Palmer E, Sheppard D 1991 Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor. J Biol Chem 266:15598-15601
15. 15. Shifrin VI, Neel BG 1993 Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA. J Biol Chem 268:25376-25384
16. 16. Metheny LJ, Skuse GR 1996 NF1 mRNA isoform expression in PC12 cells: modulation by extrinsic factors. Exp Cell Res 228:44-49
17. 17. Fichter M, Hinrichs R, Eissner G, Scheffer B, Classen S, Ueffing M 1997 Expression of CD44 isoforms in neuroblastoma cells is regulated by PI 3-kinase and protein kinase C. Oncogene 14:2817-2824
18. 18. Kosaki A, Webster NJ 1993 Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J Biol Chem 268:21990-21996
19. 19. Chalfant CE, Mischak H, Watson JE, Winkler BC, Goodnight J, Farese RV, Cooper DR 1995 Regulation of alternative splicing of protein kinase C β by insulin. J Biol Chem 270:13326-13332
20. 20. Mackay CR, Terpe HJ, Stauder R, Marston WL, Stark H, Günthert U 1994 Expression and modulation of CD44 variant isoforms in humans. J Cell Biol 124:71-82
21. 21. McKay NG, Hunter DJ, Haites NE, Power DA 1994 Regulation of alternative splicing of the fibronectin IIICS domain by cytokines. Biochem Biophys Res Commun 199:1005-1011
22. 22. Eissa NT, Strauss AJ, Haggerty CM, Choo EK, Chu SC, Moss J 1996 Alternative splicing of human inducible nitric-oxide synthase mRNA. Tissue-specific regulation and induction by cytokines. J Biol Chem 271:27184-27187
23. 23. Borsi L, Balza E, Gaggero B, Allemanni G, Zardi L 1995 The alternative splicing pattern of the tenascin-C pre-mRNA is controlled by the extracellular pH. J Biol Chem 270:6243-6245
24. 24. Zacharias DA, Strehler EE 1996 Change in plasma membrane Ca2(+)-ATPase splice-variant expression in response to a rise in intracellular Ca2+. Curr Biol 6:1642-1652
25. 25. König H, Ponta H, Herrlich P 1998 Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator. EMBO J 17:2904-2913
26. 26. Hawkins JD 1988 A survey on intron and exon lengths. Nucleic Acids Res 16:9893-9908
27. 27. Burge CB, Tuschl T, Sharp PA 1999 Splicing of precursors to mRNAs by the spliceosomes. In: Gesteland RF, Cech TR, Atkins JF (eds) The RNA World. Cold Spring Harbor Laboratory Press, Plainview, NY, pp 525-560
28. 28. Berget SM 1995 Exon recognition in vertebrate splicing. J Biol Chem 270:2411-24146
29. 29. Robberson BL, Cote GJ, Berget SM 1990 Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol Cell Biol 10:84-94
30. 30. Neugabauer KM, Roth MB 1997 Transcription units as RNA processing units. Genes Dev 11:3279-3285
31. 31. Hirose Y, Manley JL 2000 RNA polymerase II and integration of nuclear events. Genes Dev 14:1415-1429
32. 32. McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, Patterson SD, Wickens M, Bentley DL 1997 The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 385:357-361
33. 33. Yuryev A, Patturajan M, Litingtung Y, Joshi RV, Gentile C, Gebara M, Corden JL 1996 The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/ arginine-rich proteins. Proc Natl Acad Sci USA 93:6975-6980
34. 34. Hirose Y, Tacke R, Manley JL 1999 Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes Dev 13:1234-1239
35. 35. Hirose Y, Manley JL 1998 RNA polymerase II is an essential mRNA polyadenylation factor. Nature 395:93-96
36. 36. Cramer P, Caceres JF, Cazalla D, Kadener S, Muro AF, Baralle FE, Kornblihtt AR 1999 Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. Mol Cell 4:251-258
37. 37. Foulkes NS, Borrelli E, Sassone-Corsi P 1991 CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64:739-749
38. 38. Foulkes NS, Schlotter F, Pevet P, Sassone-Corsi P 1993 Pituitary hormone FSH directs the CREM functional switch during spermatogenesis. Nature 362:264-267
39. 39. Sassone-Corsi P 1998 CREM: a master-switch governing male germ cell differentiation and apoptosis. Semin Cell Dev Biol 9: 475-482
40. 40. Foulkes NS, Borjigin J, Snyder SH, Sassone-Corsi P 1996 Transcriptional control of arcadian hormone synthesis via the CREM feedback loop. Proc Natl Acad Sci USA 93:14140-14145
41. 41. Blendy JA, Kaestner KH, Schmid W, Gass P, Schutz G 1996 Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO J 15:1098-1106
42. 42. Girardet C, Walker WH, Habener JF 1996 An alternatively spliced polycistronic mRNA encoding cyclic adenosine 3′,5′-monophosphate (cAMP)-responsive transcription factor CREB (cAMP response element-binding protein) in human testis extinguishes expression of an internally translated inhibitor CREB isoform. Mol Endocrinol 10:879-891
43. 43. Walker WH, Girardet C, Habener JF 1996 Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis. J Biol Chem 271:20145-21050
44. 44. Waeber G, Meyer TE, LeSieur M, Hermann HL, Gerard N, Habener JF 1991 Developmental stage-specific expression of cyclic adenosine 3′,5′-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing [published erratum appears in Mol Endocrinol 1993 Nov;7(11): 1501]. Mol Endocrinol 5:1418-1430
45. 45. Daniel PB, Habener JF 1998 Cyclical alternative exon splicing of transcription factor cyclic adenosine monophosphate response element-binding protein (CREB) messenger ribonucleic acid during rat spermatogenesis. Endocrinology 139:3721-3729
46. 46. Gearing KL, Crickmore A, Gustafsson JA 1994 Structure of the mouse peroxisome proliferator activated receptor α gene. Biochem Biophys Res Commun 199:255-263
47. 47. Romberger DJ 1997 Fibronectin. Int J Biochem Cell Biol 29:939-943
48. 48. Colman-Lerner A, Fischman ML, Lanuza GM, Bissell DM, Kornblihtt AR, Baranao JL 1999 Evidence for a role of the alternatively spliced ED-I sequence of fibronectin during ovarian follicular development. Endocrinology 140:2541-2548
49. 49. Seino S, Seino M, Nishi S, Bell GI 1989 Structure of the human insulin receptor gene and characterization of its promoter. Proc Natl Acad Sci USA 86:114-118
50. 50. Seino S, Bell GI 1989 Alternative splicing of human insulin receptor messenger RNA. Biochem Biophys Res Commun 159: 312-316
51. 51. Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A, Vigneri R 1999 Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 19:3278-3288
52. 52. Sell SM, Reese D, Ossowski VM 1994 Insulin-inducible changes in insulin receptor mRNA splice variants. J Biol Chem 269:30769-30772
53. 53. Mosthaf L, Grako K, Dull TJ, Coussens L, Ullrich A, McClain DA 1990 Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J 9:2409-2413
54. 54. Kosaki A, Pillay TS, Xu L, Webster NJ 1995 The B isoform of the insulin receptor signals more efficiently than the A isoform in HepG2 cells. J Biol Chem 270:20816-20823
55. 55. Li Calzi S, Choice CV, Najjar SM 1997 Differential effect of pp120 on insulin endocytosis by two variant insulin receptor isoforms. Am J Physiol 273:E801-808
56. 56. Sciacca L, Costantino A, Pandini G, Mineo R, Frasca F, Scalia P, Sbraccia P, Goldfine ID, Vigneri R, Belfiore A 1999 Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism. Oncogene 18:2471-2479
57. 57. Themmen AP, Kraaij R, Grootegoed JA 1994 Regulation of gonadotropin receptor gene expression. Mol Cell Endocrinol 100: 15-19
58. 58. Tena-Sempere M, Manna PR, Huhtaniemi I 1999 Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence. Biol Reprod 60:1515-1527
59. 59. Gromoll J, Gudermann T, Nieschlag E 1992 Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor. Biochem Biophys Res Commun 188:1077-1083
60. 60. Aatsinki JT, Pietila EM, Lakkakorpi JT, Rajaniemi HJ 1992 Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript. Mol Cell Endocrinol 84:127-135
61. 61. Kraaij R, Verhoef-Post M, Grootegoed JA, Themmen AP 1998 Alternative splicing of follicle-stimulating hormone receptor premRNA: cloning and characterization of two alternatively spliced mRNA transcripts. J Endocrinol 158:127-136
62. 62. Edens A, Talamantes F 1998 Alternative processing of growth hormone receptor transcripts. Endocr Rev 19:559-582
63. 63. Baumann G 1994 Growth hormone-binding proteins: state of the art. J Endocrinol 141:1-6
64. 64. Dastot F, Sobrier ML, Duquesnoy P, Duriez B, Goossens M, Amselem S 1996 Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein. Proc Natl Acad Sci USA 93:10723-10728
65. 65. Ross RJ, Esposito N, Shen XY, Von Laue S, Chew SL, Dobson PR, Postel-Vinay MC, Finidori J 1997 A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein. Mol Endocrinol 11:265-273
66. 66. Sairam MR, Jiang LG, Yarney TA, Khan H 1997 Alternative splicing converts the G-protein coupled follitropin receptor gene into a growth factor type I receptor: implications for pleiotropic actions of the hormone. Mol Reprod Dev 48:471-479
67. 67. Khan H, Yarney TA, Sairam MR 1993 Cloning of alternately spliced mRNA transcripts coding for variants of ovine testicular follitropin receptor lacking the G protein coupling domains. Biochem Biophys Res Commun 190:888-894
68. 68. You S, Kim H, Hsu CC, El Halawani ME, Foster DN 2000 Three different turkey luteinizing hormone receptor (tLH-R) isoforms. I. Characterization of alternatively spliced tLH-R isoforms and their regulated expression in diverse tissues. Biol Reprod 62:108-116
69. 69. Yamey TA, Jiang L, Khan H, MacDonald EA, Laird DW, Sairam MR 1997 Molecular cloning, structure, and expression of a testicular follitropin receptor with selective alteration in the carboxy terminus that affects signaling function. Mol Reprod Dev 48: 458-470
70. 70. Sairam MR, Jiang LG, Yarney TA, Khan H 1996 Follitropin signal transduction: alternative splicing of the FSH receptor gene produces a dominant negative form of receptor which inhibits hormone action. Biochem Biophys Res Commun 226:717-722
71. 71. Edens A, Southard JN, Talamantes F 1994 Mouse growth hormone-binding protein and growth hormone receptor transcripts are produced from a single gene by alternative splicing. Endocrinology 135:2802-2805
72. 72. Sakai N, Tolbert LM, Duman RS 1999 Identification and functional analysis of novel cAMP response element binding protein splice variants lacking the basic/leucine zipper domain. Mol Pharmacol 56:917-925
73. 73. Bingham B, Oldham ER, Baumbach WR 1994 Regulation of growth hormone receptor and binding protein expression in domestic species. Proc Soc Exp Biol Med 206:195-199
74. 74. He Y, Smith SK, Day KA, Clark DE, Licence DR, Charnock-Jones DS 1999 Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity. Mol Endocrinol 13:537-545
75. 75. Zhang L, Liu W, Grabowski PJ 1999 Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. RNA 5:117-130
76. 76. Modafferi EF, Black DL 1997 A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol Cell Biol 17:6537-6545
77. 77. Ashiya M, Zhang L, Grabowski PJ 1995 Regulated splicing of γ2 pre-messenger RNA in neuronal cells. Nucleic Acids Symp Ser 33:215-216
78. 78. Jin W, Huang ES, Bi W, Cote GJ 1999 Redundant intronic repressors function to inhibit fibroblast growth factor receptor-1 α-exon recognition in glioblastoma cells. J Biol Chem 274:28035-28041
79. 79. Jin W, Bi W, Huang ES, Cote GJ 1999 Glioblastoma cell-specific expression of fibroblast growth factor receptor-1 beta requires an intronic repressor of RNA splicing. Cancer Res 59:316-319
80. 80. Gooding C, Roberts GC, Smith CW 1998 Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated α-tropomyosin exon. RNA 4:85-100
81. 81. Ryan KJ, Cooper TA 1996 Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol 16:4014-4023
82. 82. Cote GJ, Huang ES, Jin W, Morrison RS 1997 Sequence requirements for regulated RNA splicing of the human fibroblast growth factor receptor-1 α exon. J Biol Chem 272:1054-1060
83. 83. Huh GS, Hynes RO 1994 Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes Dev 8:1561-1574
84. 84. Zhang L, Ashiya M, Sherman TG, Grabowski PJ 1996 Essential nucleotides direct neuron-specific splicing of γ2 pre-mRNA. RNA 2:682-698
85. 85. Black DL 1992 Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro. Cell 69:795-807
86. 86. Chan RC, Black DL 1995 Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro [published erratum appears in Mol Cell Biol 1997 May;17(5):2970]. Mol Cell Biol 15: 6377-6385
87. 87. Lou H, Yang Y, Cote GJ, Berget SM, Gagel RF 1995 An intron enhancer containing a 5′ splice site sequence in the human calcitonin/calcitonin gene-related peptide gene. Mol Cell Biol 15:7135-7142
88. 88. Chandler D, McGuffin ME, Piskur J, Yao J, Baker BS, Mattox W 1997 Evolutionary conservation of regulatory strategies for the sex determination factor transformer-2. Mol Cell Biol 17:2908-2919
89. 89. Lim LP, Sharp FA 1998 Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats. Mol Cell Biol 18:3900-3906
90. 90. Chabot B, Blanchette M, Lapierre I, La Branche H 1997 An intron element modulating 5′ splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1. Mol Cell Biol 17:1776-1786
91. 91. Cooper TA, Mattox W 1997 The regulation of splice-site selection, and its role in human disease. Am J Hum Genet 61:259-266
92. 92. Valcarcel J, Gebauer F 1997 Post-transcriptional regulation: the dawn of PTB. Curr Biol 7:R705-708
93. 93. Gontarek RR, McNally MT, Beemon K 1993 Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing. Genes Dev 7:1926-1936
94. 94. Smith CW, Valcarcel J 2000 Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci 25:381-388
95. 95. Dignam JD, Lebovitz RM, Roeder RG 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489
96. 96. Siebel CW, Kanaar R, Rio DC 1994 Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. Genes Dev 8:1713-1725
97. 97. Min H, Turck CW, Nikolic JM, Black DL 1997 A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev 11:1023-1036
98. 98. Zhang B, Gallegos M, Puoti A, Durkin E, Fields S, Kimble J, Wickens MP 1997 A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature 390:477-484
99. 99. SenGupta DJ, Zhang B, Kraemer B, Pochart P, Fields S, Wickens M 1996 A three-hybrid system to detect RNA-protein interactions in vivo. Proc Natl Acad Sci USA 93:8496-8501
100. 100. Wang ZF, Whitfield ML, Ingledue III TC, Dominski Z, Marzluff WF 1996 The protein that binds the 3′ end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing. Genes Dev 10:3028-3040
101. 101. Bachler M, Schroeder R, von Ahsen U 1999 StreptoTag: a novel method for the isolation of RNA-binding proteins. RNA 5:1509-1516
102. 102. Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M 1998 Mass spectrometry and EST-database searching allows characterization of the multiprotein spliceosome complex. Nat Genet 20:46-50
103. 103. Burtis KC, Baker BS 1989 Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell 56:997-1010
104. 104. Nagoshi RN, McKeown M, Burtis KC, Belote JM, Baker BS 1988 The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster. Cell 53:229-236
105. 105. Hertel KJ, Lynch KW, Hsiao EC, Liu EH, Maniatis T 1996 Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements. RNA 2:969-981
106. 106. Ryner LC, Baker BS 1991 Regulation of doublesex pre-mRNA processing occurs by 3′-splice site activation. Genes Dev 5:2071-2085
107. 107. Hedley ML, Maniatis T 1991 Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65:579-586
108. 108. Heinrichs V, Baker BS 1995 The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J 14:3987-4000
109. 109. Lynch KW, Maniatis T1996 Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev 10:2089-2101
110. 110. Zuo P, Maniatis T 1996 The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev 10:1356-1368
111. 111. Hertel KJ, Maniatis T 1998 The function of multisite splicing enhancers. Mol Cell 1:449-455
112. 112. Siebel CW, Rio DC 1990 Regulated splicing of the Drosophila P transposable element third intron in vitro: somatic repression. Science 248:1200-1208
113. 113. Siebel CW, Fresco LD, Rio DC 1992 The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5′ splice site control U1 snRNP binding. Genes Dev 6:1386-1401
114. 114. Chain AC, Zollman S, Tseng JC, Laski FA 1991 Identification of a cis-acting sequence required for germ line-specific splicing of the P element ORF2-ORF3 intron. Mol Cell Biol 11:1538-1546
115. 115. Hammond LE, Rudner DZ, Kanaar R, Rio DC 1997 Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo. Mol Cell Biol 17:7260-7267
116. 116. Adams MD, Tarng RS, Rio DC 1997 The alternative splicing factor PSI regulates P-element third intron splicing in vivo. Genes Dev 11:129-138
117. 117. Martinez R, Mathey-Prevot B, Bernards A, Baltimore D 1987 Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart. Science 237:411-415
118. 118. Foster-Barber A, Bishop JM 1998 Src interacts with dynamin and synapsin in neuronal cells. Proc Natl Acad Sci USA 95:4673-4677
119. 119. Black DL 1991 Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells? Genes Dev 5:389-402
120. 120. Modafferi EF, Black DL 1999 Combinatorial control of a neuron-specific exon. RNA 5:687-706
121. 121. Min H, Chan RC, Black DL 1995 The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev 9:2659-2671
122. 122. Chou MY, Rooke N, Turck CW, Black DL 1999 hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol Cell Biol 19:69-77
123. 123. Chan RC, Black DL 1997 The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol 17:4667-4676
124. 124. Chou MY, Underwood JG, Nikolic J, Luu MH, Black DL 2000 Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Mol Cell 5:949-957
125. 125. Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL 2000 Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol 20:7463-7479
126. 126. Crenshaw EBd Russo AF, Swanson LW, Rosenfeld MG 1987 Neuron-specific alternative RNA processing in transgenic mice expressing a metallothionein-calcitonin fusion gene. Cell 49: 389-398
127. 127. van Oers CC, Bakker L, Baas PD 1994 The exon 4 poly(A) site of the human calcitonin/CGRP-I pre-mRNA is a weak site in vitro. Biochim Biophys Acta 1218:55-63
128. 128. Bennett MM, Amara SG 1992 Molecular mechanisms of cell-specific and regulated expression of the calcitonin/α-CGRP and β-CGRP genes. Ann NY Acad Sci 657:36-49
129. 129. Adema GJ, van Hulst KL, Baas FD 1990 Uridine branch acceptor is a cis-acting element involved in regulation of the alternative processing of calcitonin/CGRP-1 pre-mRNA. Nucleic Acids Res 18:5365-5373
130. 130. Yeakley JM, Hedjran F, Morfin JP, Merillat N, Rosenfeld MG, Emeson RB 1993 Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements. Mol Cell Biol 13:5999-6011
131. 131. Lou H, Cote GJ, Gagel RF 1994 The calcitonin exon and its flanking intronic sequences are sufficient for the regulation of human calcitonin/calcitonin gene-related peptide alternative RNA splicing. Mol Endocrinol 8:1618-1626
132. 132. Emeson RB, Hedjran F, Yeakley JM, Guise JW, Rosenfeld MG 1989 Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor. Nature 341: 76-80
133. 133. Cote GJ, Stolow DT, Peleg S, Berget SM, Gagel RF 1992 Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP. Nucleic Acids Res 20:2361-2366
134. 134. Roesser JR, Liittschwager K, Leff SE 1993 Regulation of tissue-specific splicing of the calcitonin/calcitonin gene-related peptide gene by RNA-binding proteins. J Biol Chem 268:8366-8375
135. 135. van Oers CC, Adema GJ, Zandberg H, Moen TC, Baas PD 1994 Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA. Mol Cell Biol 14:951-960
136. 136. Hedjran F, Yeakley JM, Huh GS, Hynes RO, Rosenfeld MG 1997 Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proc Natl Acad Sci USA 94:12343-12347
137. 137. Coleman TP, Roesser JR 1998 RNA secondary structure: an important cis-element in rat calcitonin/CGRP pre-messenger RNA splicing. Biochemistry 37:15941-15950
138. 138. Lou H, Gagel RF, Berget SM 1996 An intron enhancer recognized by splicing factors activates polyadenylation. Genes Dev 10:208-219
139. 139. Lou H, Neugebauer KM, Gagel RF, Berget SM 1998 Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol 18:4977-4985
140. 140. Lou H, Helfman DM, Gagel RF, Berget SM 1999 Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3′-terminal exon. Mol Cell Biol 19:78-85
141. 141. Colgan DF, Manley JL 1997 Mechanism and regulation of mRNA polyadenylation. Genes Dev 11:2755-2766
142. 142. Campos RV, Zhang L, Drucker DJ 1994 Differential expression of RNA transcripts encoding unique carboxy-terminal sequences of human parathyroid hormone-related peptide. Mol Endocrinol 8:1656-1666
143. 143. Flouriot G, Griffin C, Kenealy M, Sonntag-Buck V, Gannon F 1998 Diffferentially expressed messenger RNA isoforms of the human estrogen receptor-α gene are generated by alternative splicing and promoter usage. Mol Endocrinol 12:1939-1954
144. 144. Hanstein B, Liu H, Yancisin MC, Brown M 1999 Functional analysis of a novel estrogen receptor-β isoform. Mol Endocrinol 13: 129-137
145. 145. DeNoto FM, Moore DD, Goodman HM 1981 Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Nucleic Acids Res 9:3719-3730
146. 146. Hampson RK, Rottman FM 1987 Alternative processing of bovine growth hormone mRNA: nonsplicing of the final intron predicts a high molecular weight variant of bovine growth hormone. Proc Natl Acad Sci USA 84:2673-2677
147. 147. Chua Jr SC, Koutras IK, Han L, Liu SM, Kay J, Young SJ, Chung WK, Leibel RL 1997 Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45:264-270
148. 148. Ivanchuk SM, Myers SM, Mulligan LM 1998 Expression of RET 3′ splicing variants during human kidney development. Oncogene 16:991-996
149. 149. Novotny J, Svoboda P 1998 The long (Gs(alpha)-L) and short (Gs(alpha)-S) variants of the stimulatory guanine nucleotide-binding protein. Do they behave in an identical way? J Mol Endocrinol 20:163-173
150. 150. Wei N, Lin CQ, Modafferi EF, Gomes WA, Black DL 1997 A unique intronic splicing enhancer controls the inclusion of the agrin Y exon. RNA 3:1275-1288
151. 151. Humphrey MB, Bryan J, Cooper TA, Berget SM 1995 A 32-nucleotide exon-splicing enhancer regulates usage of competing 5′ splice sites in a differential internal exon. Mol Cell Biol 15:3979-3988
152. 152. Chew SL, Baginsky L, Eperon IC 2000 An exonic splicing silencer in the testes-specific DNA ligase III β exon. Nucleic Acids Res 28:402-410
153. 153. Jin W, Huang ES, Bi W, Cote GJ 1998 Exon sequence is required for regulated RNA splicing of the human fibroblast growth factor receptor-1 α-exon. J Biol Chem 273:16170-16176
154. 154. Carstens RP, McKeehan WL, Garcia-Blanco MA 1998 An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol 18:2205-2217
155. 155. Lavigueur A, La Branche H, Kornblihtt AR, Chabot B 1993 A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev 7:2405-2417
156. 156. Caputi M, Casari G, Guenzi S, Tagliabue R, Sidoli A, Melo CA, Baralle FE 1994 A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon. Nucleic Acids Res 22:1018-1022
157. 157. Staffa A, Acheson NH, Cochrane A 1997 Novel exonic elements that modulate splicing of the human fibronectin EDA exon. J Biol Chem 272:33394-33401
158. 158. Uporova TM, Norton PA, Tuan RS, Bennett VD 1999 Alternative splicing during chondrogenesis: cis and trans factors involved in splicing of fibronectin exon EIIIA. J Cell Biochem 76:341-351
159. 159. Sun Q, Hampson RK, Rottman FM 1993 In vitro analysis of bovine growth hormone pre-mRNA alternative splicing. Involvement of exon sequences and trans-acting factor(s). J Biol Chem 268:15659-15666
160. 160. Watakabe A, Tanaka K, Shimura Y 1993 The role of exon sequences in splice site selection. Genes Dev 7:407-418
161. 161. Kan JL, Green MR 1999 Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. Genes Dev 13:462-471
162. 162. Kosaki A, Nelson J, Webster NJ 1998 Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA. J Biol Chem 273:10331-10337
163. 163. Dye BT, Buvoli M, Mayer SA, Lin CH, Patton JG 1998 Enhancer elements activate the weak 3′ splice site of α-tropomyosin exon 2. RNA 4:1523-1536
164. 164. Gooding C, Roberts GC, Moreau G, Nadal-Ginard B, Smith CW 1994 Smooth muscle-specific switching of α-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J 13:3861-3872
165. 165. Graham IR, Hamshere M, Eperon IC 1992 Alternative splicing of a human α-tropomyosin muscle-specific exon: identification of determining sequences. Mol Cell Biol 12:3872-3882
166. 166. Sirand-Pugnet P, Durosay P, Brody E, Marie J 1995 An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken β-tropomyosin pre-mRNA. Nucleic Acids Res 23:3501-3507
167. 167. Clouet d'Orval B, d'Aubenton Carafa Y, Sirand-Pugnet P, Gallego M, Brody E, Marie J 1991 RNA secondary structure repression of a muscle-specific exon in HeLa cell nuclear extracts. Science 252:1823-1828
168. 168. Libri D, Piseri A, Fiszman MY 1991 Tissue-specific splicing in vivo of the β-tropomyosin gene: dependence on an RNA secondary structure. Science 252:1842-1845
169. 169. Chen CD, Kobayashi R, Helfman DM 1999 Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat β-tropomyosin gene. Genes Dev 13:593-606
170. 170. Xu R, Teng J, Cooper TA 1993 The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol 13:3660-3674
171. 171. Philips AV, Timchenko LT, Cooper TA 1998 Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 280:737-741