Phosphorylated RNA polymerase II stimulates pre-mRNA splicing

Genes and Development

Volumn 13, Issue 10, 1999, Pages 1234-1239

  Hirose, Yutaka ^a,b   Tacke, Roland ^a   Manley, James L ^a  

^a Columbia University ^*  (United States)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

In vitro slicing; Phosphorylation; RNA processing; RNAP II isoforms

Indexed keywords

MESSENGER RNA; RNA POLYMERASE II;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EUKARYOTIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RNA PROCESSING; RNA SPLICING; RNA TRANSCRIPTION; SPLICEOSOME;

EUKARYOTA;

EID: 0033563098     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.10.1234     Document Type: Article

References (38)

1. Bauren, G. and L. Wieslander. 1994. Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription. Cell 76: 183-192.
2. Besse, S., M. Vigneron, E. Pichard, and F. Puvion-Dutilleul. 1995. Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: The role of interchromatin granules. Gene Expr. 4: 143-161.
3. Beyer, A.L., N. Yvonne, and Y.N. Osheim. 1988. Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes & Dev. 2: 754-765.
4. Chabot, B., S. Bisotto, and M. Vincent. 1995. The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle. Nucleic Acids Res. 23: 3206-3213.
5. Cho, E.J., T. Takagi, C.R. Moore, and S. Buratowski. 1997. mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminat domain. Genes & Dev. 11: 3319-3326.
6. Corden, J.L. 1990. Tails of RNA polymerase II. Trends Biochem. Sci. 10: 383-387.
7. Corden, J.L. and M. Patturajan. 1997. A CTD function linking transcription to splicing. Trends Biochem. Sci. 22: 413-416.
8. Dahmus, M.E. 1996. Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271: 19009-19012.
9. Du, L. and S.L. Warren. 1997. A functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-mRNA splicing. J. Cell Biol. 136: 5-18.
10. Fu, X.D. 1993. Specific commitment of different pre-mRNAs to splicing by single SR proteins. Nature 365: 82-85.
11. _. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1: 663-680.
12. Hirose, Y. and J.L. Manley. 1998. RNA polymerase II is an essential mRNA polyadenylation factor. Nature 395: 93-96.
13. Kim, E., L. Du, D.B. Bregman, and S.L. Warren. 1997. Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNA. J. Cell Biol. 136: 19-28.
14. Krainer, A.R., G.C. Conway, and D. Kozak. 1990. Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes & Dev. 4: 1158-1171.
15. Kramer, A. 1996. The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu. Rev. Biochem. 65: 367-409.
16. Lu, H., O. Flores, R. Weinmann, and D. Reinberg. 1991. The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex. Proc. Natl. Acad. Sci. 88: 10004-10008.
17. Manley, J.L. and R. Tacke. 1996. SR proteins and splicing control. Genes & Dev. 10: 1569-1579.
18. McCracken, S., N. Fong, E. Rosonina, K. Yankulov, G. Brothers, D. Siderovski, A. Hessel, S. Foster, Amgen EST Program, S. Shuman, and D.L. Bentley. 1997a. 5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. Genes & Dev. 11: 3306-3318.
19. McCracken, S., N. Fong, K. Yankulov, S. Ballantyne, G. Pan, J. Greenblatt, S.D. Patterson, M. Wickens, and D.L. Bentley. 1997b. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 385: 357-361.
20. Moore, M.J., C.C. Query, and P.A. Sharp. 1993. Splicing O9F precursors to mRNAs by the spliceosome. In The RNA world (ed. R.F. Gesteland and J.F. Atkins), pp. 303-358. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
21. Mortillaro, M.J., B.J Blencowe, X. Wei, H. Nakayasu, L. Du, S.L. Warren, P.A. Sharp, and R. Berezney. 1996. A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. Proc. Natl. Acad. Sci. 93: 8253-8257.
22. Neugebauer, K.M. and M.B. Roth. 1997. Transcription units as RNA processing units. Genes & Dev. 11: 3279-3285.
23. O'Brien, T., S. Hardin, A. Greenleaf, and J.T. Lis. 1994. Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation. Nature 370: 75-77.
24. Patturajan, M., R.J. Schulte, B.M. Sefton, R. Berezney, M. Vincent, O. Bensaude, S.L. Warren, and J.L. Corden. 1998a. Growth-related changes in phosphorylation of yeast RNA polymerase II. J. Biol. Chem. 273: 4689-4694.
25. Patturajan, M., X. Wei, R. Berezney, and J.L. Corden. 1998b. A nuclear matrix protein interacts with the phosphorylated C-terminal domain of RNA polymerase II. Mol. Cell. Biol. 18: 2406-2415.
26. Roth, M.B., C. Murphy, and J.G. Gall. 1990. A monoclonal antibody that recognizes a phophorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle. J. Cell Biol. 111: 2217-2223.
27. Steinmetz, E.J. 1997. Pre-mRNA processing and the CTD of RNA polymerase II: The tail that wags the dog? Cell 89: 491-494.
28. Tacke, R. and J.L. Manley. 1995. The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J. 14: 3540-3551.
29. Tacke, R., M. Tohyama, S. Ogawa, and J.L. Manley. 1998. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 93: 139-148.
30. Valcárcel, J. and M.R. Green. 1996. The SR protein family: Pleiotropic functions in pre-mRNA splicing. Trends Biochem. Sci. 21: 296-301.
31. Watakabe, A., K. Tanaka, and Y. Shimura. 1993. The role of exon sequences in splice site selection. Genes & Dev. 7: 407-418.
32. Weeks, J.R., S.E. Hardin, J. Shen, J.M. Lee, and A.L. Greenleaf. 1993. Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: Correlations with gene activity and transcript processing. Genes & Dev. 7: 2329-2344.
33. Weil, P.A., D.S. Luse, J. Segall, and R.G. Roeder. 1979. Selective and accurate initiation of transcription at the Ad2 major late promoter in a soluble system dependent on purified RNA polymerase II and DNA. Cell 18: 469-484.
34. Yeakley, J.M., J.P. Morfin, M.G. Rosenfeld, and X.D. Fu. 1996. A complex of nuclear proteins mediates SR protein binding to a purine-rich splicing enhancer. Proc. Natl. Acad. Sci. 93: 7582-7587.
35. Yue, Z., E. Maldonado, R. Pillutla, H. Cho, D. Reinberg, and A.J. Shatkin. 1997. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II. Proc. Natl. Acad. Sci. 94: 12898-12903.
36. Yuryev, A., M. Patturajan, Y. Litingtung, R.V. Joshi, C. Gentile, M. Gebara, and J.L. Corden. 1996. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/ arginine-rich proteins. Proc. Natl. Acad. Sci. 93: 6975-6980.
37. Zahler, A.M., W.S. Lane, J.A. Stolk, and M.B. Roth. 1992. SR proteins: A conserved family of pre-mRNA splicing factors. Genes & Dev. 6: 837-847.
38. Zhang, G., K.L. Taneja, R.H. Singer, and M.R. Green. 1994. Localization of pre-mRNA splicing in mammalian nuclei. Nature 372: 809-812.