An intron element modulating 5' splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1

Molecular and Cellular Biology

Volumn 17, Issue 4, 1997, Pages 1776-1786

  Chabot, Benoit ^a   Blanchette, Marco ^a   Lapierre, Isabelle ^a   Branche, Hélène La ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA PRECURSOR; RIBONUCLEASE H; RIBONUCLEOPROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; BINDING SITE; EXON; GENOME; IMMUNOPRECIPITATION; INTRON; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA SPLICING;

MURINAE;

EID: 0030952320     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.4.1776     Document Type: Article

References (75)

1. Abdul-Manan, N., S. M. O'Malley, and K. R. Williams. 1996. Origins of binding specificity of the A1 heterogeneous nuclear ribonucleoprotein. Biochemistry 35:3545-3554.
2. Bell, L. R., J. I. Horabin, P. Schedl, and T. W. Cline. 1991. Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila. Cell 65:229-239.
3. Ben-David, Y., M. R. Bani, B. Chabot, A. De Koven, and A. Bernstein. 1992. Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth. Mol. Cell. Biol. 12:4449-4455.
4. Biamonti, G., M. Buvoli, M. T. Bassi, C. Morandi, F. Cobianchi, and S. Riva. 1989. Isolation of an active gene encoding human hnRNP protein A1. Evidence for alternative splicing. J. Mol. Biol. 207:491-503.
5. Black, D. L. 1995. Finding splice sites within a wilderness of RNA. RNA 1:763-771.
6. Black, D. L., B. Chabot, and J. A. Steitz. 1985. U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell 42:737-750.
7. Blanchette, M., and B. Chabot. A highly stable duplex structure sequesters the 5′ splice site region of hnRNP A1 alternative exon 7B. RNA, in press.
8. Burd, C. G., and G. Dreyfuss. 1994. RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J. 13:1197-1204.
9. Buvoli, M., F. Cobianchi, M. G. Bestagno, A. Mangiarotti, M. T. Bassi, G. Biamonti, and S. Riva. 1990. Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. EMBO J. 9:1229-1235.
10. Buvoli, M., F. Cobianchi, and S. Riva. 1992. Interaction of hnRNP A1 with snRNPs and pre-mRNAs: evidence for a possible role of A1 RNA annealing activity in the first steps of spliceosome assembly. Nucleic Acids Res. 20: 5017-5025.
11. Cáceres, J. F., S. Stamm, D. M. Helfman, and A. R. Krainer. 1994. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 265:1706-1709.
12. Caffreli, E., P. Fragapane, C. Gehring, and I. Bozzoni. 1987. The accumulation of mature RNA for the Xenopus laevis ribosomal protein L1 is controlled at the level of splicing and turnover of the precursor RNA. EMBO J. 6:3493-3498.
13. Carlo, T., D. A. Sterner, and S. M. Berget. 1996. An intron splicing enhancer containing a G-rich repeat facilitates inclusion of a vertebrate micro-exon. RNA 2:342-353.
14. Cartegni, L., M. Maconi, E. Morandi, F. Cobianchi, S. Riva, and G. Biamonti. 1996. hnRNP A1 selectively interacts through its gly-rich domain with different RNA-binding proteins. J. Mol. Biol. 259:337-348.
15. Casas-Finet, J. R., J. D. Smith, Jr., A. Kumar, J. G. Kim, S. H. Wilson, and R. L. Karpel. 1993. Mammalian heterogeneous ribonucleoprotein A1 and its constituent domains. Nucleic acid interaction, structural stability and self-association. J. Mol. Biol. 229:873-889.
16. Chabot, B. 1994. Synthesis and purification of RNA substrates, p. 1-29. In S. J. Higgins and B. D. Hames (ed.), RNA processing - a practical approach, vol. I. IRL Press, Oxford, United Kingdom.
17. Chabot, B. 1996. Directing alternative splicing: cast and scenarios. Trends Genet. 12:472-478.
18. Chabot, B., and J. A. Steitz. 1987. Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol. Cell. Biol. 7:281-293.
19. Cobianchi, F., G. Biamonti, M. Maconi, and S. Riva. 1994. Human hnRNP protein A1: a model polypeptide for a structural and genetic investigation of a broad family of RNA binding proteins. Genetica 94:101-114.
20. Del Gatto, F., and R. Breathnach. 1995. Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol. Cell. Biol. 15:4825-4834.
21. Del Gatto, F., M.-C. Gesnel, and R. Breathnach. 1996. The exon sequence TAGG can inhibit splicing. Nucleic Acids Res. 24:2017-2021.
22. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1992. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
23. Dominski, Z., and R. Kole. 1994. Identification of exon sequences involved in splice site selection. J. Biol. Chem. 269:23590-23596.
24. Eperon, I. C., D. C. Ireland, R. A. Smith, A. Mayeda, and A. R. Krainer. 1993. Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF. EMBO J. 12:3607-3617.
25. Estes, P. A., N. E. Cooke, and S. A. Liebhaber. 1992. A native RNA secondary structure controls alternative splice-site selection and generates two human growth hormone isoforms. J. Biol. Chem. 267:14902-14908.
26. Fu, X.-D. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1:663-680.
27. Gontarek, R. R., M. T. McNally, and K. Beemon. 1993. Mutations of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing. Genes Dev. 7:1926-1936.
28. Green, M. R. 1991. Biochemical mechanisms of constitutive and regulated pre-mRNA splicing. Annu. Rev. Cell Biol. 7:559-599.
29. Guthrie, C. 1991. Messenger RNA splicing in yeast: clues to why the spliceosome is a ribonucleoprotein. Science 253:157-163.
30. Hedley, M. L., and T. Maniatis. 1991. Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65:579-586.
31. Heinrichs, V., and B. S. Baker. 1995. The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J. 14:3987-4000.
32. Hoffman, B. E., and P. J. Grabowski. 1992. U1 snRNP targets an essential splicing factor, U2AF65, to the 3′ splice site by a network of interactions spanning the exon. Genes Dev. 6:2554-2568.
33. Hoshijima, K., K. Inoue, I. Higuchi, H. Sakamoto, and Y. Shimura. 1991. Control of doublesex alternative splicing by transformer and transformer-2 in Drosophila. Science 252:833-836.
34. Huh, G. S., and R. O. Hynes. 1994. Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes Dev. 8:1561-1574.
35. Krainer, A. R., and T. Maniatis. 1985. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell 42:725-736.
36. Lapierre, I., L. Narasiah, and B. Chabot. Unpublished data.
37. Lavigueur, A., H. La Branche, A. R. Kornblihtt, and B. Chabot. 1993. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes Dev. 7:2405-2417.
38. Lin, C.-H., and J. G. Patton. 1995. Regulation of alternative 3′ splice site selection by constitutive splicing factors. RNA 1:234-245.
39. Lynch, K. W., and T. Maniatis. 1995. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev. 9:284-293.
40. Mattox, W., and B. S. Baker. 1991. Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila. Genes Dev. 5:786-796.
41. Mayeda, A., D. M. Helfman, and A. R. Krainer. 1993. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol. Cell. Biol. 13:2993-3001.
42. Mayeda, A., and A. R. Krainer. 1992. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68:365-375.
43. Mayeda, A., S. M. Munroe, J. F. Cáceres, and A. R. Krainer. 1994. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J. 13:5483-5495.
44. McAfee, J. G., M. Huang, S. Soltaninassab, J. E. Rech, S. Iyengar, and W. N. LeStourgeon. The packaging of pre-mRNA. In A. R. Krainer (ed.), Frontiers in molecular biology, in press. Oxford University Press, Oxford, England.
45. Min, H., R. C. Chan, and D. L. Black. 1995. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev. 9:2659-2671.
46. Moore, M. J., C. C. Query, and P. A. Sharp. 1993. Splicing of precursors to messenger RNAs by the spliceosome, p. 303-357. In R. F. Gesteland and J. F. Atkins (ed.), The RNA world. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
47. Narasiah, L., and B. Chabot. Unpublished data.
48. Nemeroff, M. E., U. Utans, A. Krämer, and R. M. Krug. 1992. Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes. Mol. Cell. Biol. 12:962-970.
49. Nilsen, T. W. 1994. RNA-RNA interactions in the spliceosome: unraveling the ties that bind. Cell 78:1-4.
50. Pontius, B. W., and P. Berg. 1992. Rapid assembly and disassembly of complementary DNA strands through an equilibrium intermediate state mediated by A1 hnRNP protein. J. Biol. Chem. 267:13815-13818.
51. Ramchatesingh, J., A. M. Zahler, K. M. Neugebauer, M. B. Roth, and T. A. Cooper. 1995. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol. Cell. Biol. 15:4898-4907.
52. Robberson, B. L., G. J. Cote, and S. M. Berget. 1990. Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol. Cell. Biol. 10:84-94.
53. Ryner, L. C., and B. S. Baker. 1991. Regulation of doublesex pre-mRNA processing occurs by 3′-splice site activation. Genes Dev. 5:2071-2085.
54. Sharp, P. A. 1994. Split genes and RNA splicing. Cell 77:805-815.
55. Siebel, C. W., A. Admon, and D. C. Rio. 1995. Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes Dev. 9:269-283.
56. Sirand-Pugnet, P., P. Durosay, E. Brody, and J. Marie. 1995. An intronic (A/U)GGG repeat enhances the splicing of an alternative intron of the chicken b-tropomyosin pre-mRNA. Nucleic Acids Res. 23:3501-3507.
57. Sirand-Pugnet, P., P. Durosay, B. Clouet d'Orval, E. Brody, and J. Marie. 1995. β-Tropomyosin pre-mRNA folding around a muscle-specific exon interferes with several steps of spliceosome assembly. J. Mol. Biol. 251:591-602.
58. Staknis, D., and R. Reed. 1994. SR proteins promote the first specific recognition of pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol. Cell. Biol. 14:7670-7682.
59. Sun, Q., A. Mayeda, R. K. Hampson, A. R. Krainer, and F. M. Rottman. 1993. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev. 7:2598-2608.
60. Swanson, M. S., and G. Dreyfuss. 1988. RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns. EMBO J. 7:3519-3529.
61. Tanaka, K., A. Watakabe, and Y. Shimura. 1994. Polypurine sequences within a downstream exon function as a splicing enhancer. Mol. Cell. Biol. 14:1347-1354.
62. Tian, M., and T. Maniatis. 1992. Positive control of pre-mRNA splicing in vitro. Science 256:237-240.
63. Tian, M., and T. Maniatis. 1993. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74:105-114.
64. Tian, M., and T. Maniatis. 1994. A splicing enhancer exhibits both constitutive and regulated activities. Genes Dev. 8:1703-1712.
65. Tsukahara, T., C. Casciato, and D. M. Helfman. 1994. Alternative splicing of β-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5′- and 3′-splice sites of the nonmuscle/smooth muscle exon 6. Nucleic Acids Res. 22:2318-2325.
66. Valcárcel, J., R. Singh, P. D. Zamore, and M. R. Green. 1993. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. Nature 362:171-175.
67. van Oers, C. C. M., G. J. Adema, H. Zandberg, T. C. Moen, and P. D. Baas. 1994. Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA. Mol. Cell. Biol. 14:951-960.
68. Vilardell, J., and J. R. Warner. 1994. Regulation of splicing at an intermediate step in the formation of the spliceosome. Genes Dev. 8:211-220.
69. Wang, Z., H. M. Hoffmann, and P. J. Grabowski. 1995. Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity. RNA 1:21-35.
70. Watakabe, A., K. Tanaka, and Y. Shimura. 1993. The role of exon sequences in splice site selection. Genes Dev. 7:407-418.
71. Xu, R., J. Teng, and T. A. Cooper. 1993. The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol. Cell. Biol. 13:3660-3674.
72. B proteins of heterogeneous nuclear ribonucleoparticles modulate 5′ splice site selection in vivo. Proc. Natl. Acad. Sci. USA 91:6924-6928.
73. Yeakley, J. M., F. Hedjran, J. P. Morfin, N. Merillat, M. G. Rosenfeld, and R. B. Emeson. 1993. Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements. Mol. Cell. Biol. 13:5999-6011.
74. Zachar, Z., T. B. Chou, and P. M. Bingham. 1987. Evidence that a regulatory gene autoregulates splicing of its transcript. EMBO J. 6:4105-4111.
75. Zahler, A. M., W. S. Lane, J. A. Stolk, and M. B. Roth. 1992. SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev. 6:837-847.