-
1
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81: 323-30, 1995
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
2
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-31, 1997
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
3
-
-
0028121279
-
A cell cycle regulator potentially involved in genesis of many tumor types
-
Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS, 3rd, Johnson BE, Skolnick MH: A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-40, 1994
-
(1994)
Science
, vol.264
, pp. 436-440
-
-
Kamb, A.1
Gruis, N.A.2
Weaver-Feldhaus, J.3
Liu, Q.4
Harshman, K.5
Tavtigian, S.V.6
Stockert, E.7
Day R.S. III8
Johnson, B.E.9
Skolnick, M.H.10
-
4
-
-
0027769876
-
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
-
Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-7, 1993
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano, M.1
Hannon, G.J.2
Beach, D.3
-
5
-
-
0028980262
-
A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies
-
Duro D, Bernard O, Della Valle V, Berger R, Larsen CJ: A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies. Oncogene 11: 21-9, 1995
-
(1995)
Oncogene
, vol.11
, pp. 21-29
-
-
Duro, D.1
Bernard, O.2
Della Valle, V.3
Berger, R.4
Larsen, C.J.5
-
6
-
-
0028982932
-
A novel p16INK4A transcript
-
Mao L, Merlo A, Bedi G, Shapiro GI, Edwards CD, Rollins BJ, Sidransky D: A novel p16INK4A transcript. Cancer Res 55: 2995-7, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 2995-2997
-
-
Mao, L.1
Merlo, A.2
Bedi, G.3
Shapiro, G.I.4
Edwards, C.D.5
Rollins, B.J.6
Sidransky, D.7
-
7
-
-
0029119852
-
Cloning and characterization of murine p16INK4a and p15INK4b genes
-
Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ, Serrano M: Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 11: 635-45, 1995
-
(1995)
Oncogene
, vol.11
, pp. 635-645
-
-
Quelle, D.E.1
Ashmun, R.A.2
Hannon, G.J.3
Rehberger, P.A.4
Trono, D.5
Richter, K.H.6
Walker, C.7
Beach, D.8
Sherr, C.J.9
Serrano, M.10
-
8
-
-
0029060657
-
Complex structure and regulation of the P16 (MTS1) locus
-
Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A: Complex structure and regulation of the P16 (MTS1) locus. Cancer Res 55: 2988-94, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 2988-2994
-
-
Stone, S.1
Jiang, P.2
Dayananth, P.3
Tavtigian, S.V.4
Katcher, H.5
Parry, D.6
Peters, G.7
Kamb, A.8
-
9
-
-
0033988257
-
INK4d-deficient mice are fertile despite testicular atrophy
-
Zindy F, van Deursen J, Grosveld G, Sherr CJ, Roussel MF: INK4d-deficient mice are fertile despite testicular atrophy. Mol Cell Biol 20: 372-8, 2000
-
(2000)
Mol Cell Biol
, vol.20
, pp. 372-378
-
-
Zindy, F.1
Van Deursen, J.2
Grosveld, G.3
Sherr, C.J.4
Roussel, M.F.5
-
10
-
-
0032530112
-
CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
-
Franklin DS, Godfrey VL, Lee H, Kovalev GI, Schoonhoven R, Chen-Kiang S, Su L, Xiong Y: CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev 12: 2899-911, 1998
-
(1998)
Genes Dev
, vol.12
, pp. 2899-2911
-
-
Franklin, D.S.1
Godfrey, V.L.2
Lee, H.3
Kovalev, G.I.4
Schoonhoven, R.5
Chen-Kiang, S.6
Su, L.7
Xiong, Y.8
-
11
-
-
0033588882
-
The INK4 family of cell cycle inhibitors in cancer
-
Roussel MF: The INK4 family of cell cycle inhibitors in cancer. Oncogene 18: 5311-7, 1999
-
(1999)
Oncogene
, vol.18
, pp. 5311-5317
-
-
Roussel, M.F.1
-
12
-
-
0033574614
-
Mechanisms of cyclin-dependent kinase regulation: Structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors
-
Pavletich NP: Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J Mol Biol 287: 821-8, 1999
-
(1999)
J Mol Biol
, vol.287
, pp. 821-828
-
-
Pavletich, N.P.1
-
13
-
-
0029052951
-
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
-
Koh J, Enders GH, Dynlacht BD, Harlow E: Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375: 506-10, 1995
-
(1995)
Nature
, vol.375
, pp. 506-510
-
-
Koh, J.1
Enders, G.H.2
Dynlacht, B.D.3
Harlow, E.4
-
14
-
-
0033082448
-
Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6
-
Noh SJ, Li Y, Xiong Y, Guan KL: Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. Cancer Res 59: 558-64, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 558-564
-
-
Noh, S.J.1
Li, Y.2
Xiong, Y.3
Guan, K.L.4
-
15
-
-
0032981481
-
Induced expression of p16(INK4a) inhibits both CDK4- And CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
-
McConnell BB, Gregory FJ, Stott FJ, Hara E, Peters G: Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes. Mol Cell Biol 19: 1981-9, 1999
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1981-1989
-
-
McConnell, B.B.1
Gregory, F.J.2
Stott, F.J.3
Hara, E.4
Peters, G.5
-
16
-
-
0028869884
-
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product
-
Parry D, Bates S, Mann DJ, Peters G: Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. Embo J 14: 503-11, 1995
-
(1995)
Embo J
, vol.14
, pp. 503-511
-
-
Parry, D.1
Bates, S.2
Mann, D.J.3
Peters, G.4
-
17
-
-
0032980425
-
Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors
-
Parry D, Mahony D, Wills K, Lees E: Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors. Mol Cell Biol 19: 1775-83, 1999
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1775-1783
-
-
Parry, D.1
Mahony, D.2
Wills, K.3
Lees, E.4
-
18
-
-
0032541623
-
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
-
Russo AA, Tong L, Lee JO, Jeffrey PD, Pavletich NP: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395: 237-43, 1998
-
(1998)
Nature
, vol.395
, pp. 237-243
-
-
Russo, A.A.1
Tong, L.2
Lee, J.O.3
Jeffrey, P.D.4
Pavletich, N.P.5
-
19
-
-
0032541640
-
Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d
-
Brotherton DH, Dhanara V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ: Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature 395: 244-50, 1998
-
(1998)
Nature
, vol.395
, pp. 244-250
-
-
Brotherton, D.H.1
Dhanara, V.2
Wick, S.3
Brizuela, L.4
Domaille, P.J.5
Volyanik, E.6
Xu, X.7
Parisini, E.8
Smith, B.O.9
Archer, S.J.10
-
20
-
-
0029054399
-
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
-
Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J: Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375: 503-6, 1995
-
(1995)
Nature
, vol.375
, pp. 503-506
-
-
Lukas, J.1
Parry, D.2
Aagaard, L.3
Mann, D.J.4
Bartkova, J.5
Strauss, M.6
Peters, G.7
Bartek, J.8
-
21
-
-
0030070484
-
CDKN2/p16 or RB alterations occur in the ma ority of glioblastomas and are inversely correlated
-
Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN: CDKN2/p16 or RB alterations occur in the ma ority of glioblastomas and are inversely correlated. Cancer Res 56: 150-3, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 150-153
-
-
Ueki, K.1
Ono, Y.2
Henson, J.W.3
Efird, J.T.4
Von Deimling, A.5
Louis, D.N.6
-
22
-
-
0028034775
-
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
-
Li Y, Nichols MA, Shay JW, Xiong Y: Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res 54: 6078-82, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 6078-6082
-
-
Li, Y.1
Nichols, M.A.2
Shay, J.W.3
Xiong, Y.4
-
23
-
-
0031594707
-
p16INK4a participates in a G1 arrest checkpoint in response to DNa damage
-
Shapiro GI, Edwards CD, Ewen ME, Rollins BJ: p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol Cell Biol 18: 378-87, 1998
-
(1998)
Mol Cell Biol
, vol.18
, pp. 378-387
-
-
Shapiro, G.I.1
Edwards, C.D.2
Ewen, M.E.3
Rollins, B.J.4
-
24
-
-
9544251503
-
p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro
-
Liggett WH Jr, Sewell DA, Rocco J, Ahrendt SA, Koch W, Sidransky D: p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res 56: 4119-23, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 4119-4123
-
-
Liggett W.H., Jr.1
Sewell, D.A.2
Rocco, J.3
Ahrendt, S.A.4
Koch, W.5
Sidransky, D.6
-
25
-
-
0030613650
-
Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: Evidence for an RB-independent growth suppressive pathway
-
Arap W, Knudsen E, Sewell DA, Sidransky D, Wang JY, Huang HJ, Cavenee WK: Functional analysis of wild-type and malignant glioma derived CDKN2Abeta alleles: evidence for an RB-independent growth suppressive pathway. Oncogene 15: 2013-20, 1997
-
(1997)
Oncogene
, vol.15
, pp. 2013-2020
-
-
Arap, W.1
Knudsen, E.2
Sewell, D.A.3
Sidransky, D.4
Wang, J.Y.5
Huang, H.J.6
Cavenee, W.K.7
-
26
-
-
0033130010
-
Nucleolar Arf sequesters Mdm2 and activates p53
-
Weber JD, Taylor LJ, Roussel MF, Sherr CJ, Bar-Sagi D: Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol 1: 20-6, 1999
-
(1999)
Nat Cell Biol
, vol.1
, pp. 20-26
-
-
Weber, J.D.1
Taylor, L.J.2
Roussel, M.F.3
Sherr, C.J.4
Bar-Sagi, D.5
-
27
-
-
0033536063
-
P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
-
Tao W, Levine AJ: P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci USA 96: 6937-41, 1999
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6937-6941
-
-
Tao, W.1
Levine, A.J.2
-
28
-
-
0031771497
-
The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNa methylation and down-regulated by wild-type p53
-
Robertson KD, Jones PA: The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol 18: 6457-73, 1998
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6457-6473
-
-
Robertson, K.D.1
Jones, P.A.2
-
29
-
-
0032169516
-
The alternative product from the human CDKN2a locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
-
Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH: The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. Embo J 17: 5001-14, 1998
-
(1998)
Embo J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
McConnell, B.B.4
Starborg, M.5
Brookes, S.6
Palmero, I.7
Ryan, K.8
Hara, E.9
Vousden, K.H.10
-
30
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle DE, Zindy F, Ashmun RA, Sherr CJ: Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83: 993-1000, 1995
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
31
-
-
0032493350
-
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
-
Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF, Sherr CJ: Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci USA 95: 8292-7, 1998
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8292-8297
-
-
Kamijo, T.1
Weber, J.D.2
Zambetti, G.3
Zindy, F.4
Roussel, M.F.5
Sherr, C.J.6
-
32
-
-
0032145569
-
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
-
Zindy F, Eischen CM, Randle DH, Kamijo T, Cleveland JL, Sherr CJ, Roussel MF: Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 12: 2424-33, 1998
-
(1998)
Genes Dev
, vol.12
, pp. 2424-2433
-
-
Zindy, F.1
Eischen, C.M.2
Randle, D.H.3
Kamijo, T.4
Cleveland, J.L.5
Sherr, C.J.6
Roussel, M.F.7
-
33
-
-
0032146795
-
E1A signaling to p53 involves the p19(ARF) tumor suppressor
-
de Stanchina E, McCurrach ME, Zindy F, Shieh SY, Ferbeyre G, Samuelson AV, Prives C, Roussel MF, Sherr CJ, Lowe SW: E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 12: 2434-42, 1998
-
(1998)
Genes Dev
, vol.12
, pp. 2434-2442
-
-
De Stanchina, E.1
McCurrach, M.E.2
Zindy, F.3
Shieh, S.Y.4
Ferbeyre, G.5
Samuelson, A.V.6
Prives, C.7
Roussel, M.F.8
Sherr, C.J.9
Lowe, S.W.10
-
34
-
-
0029993450
-
Role of the INK4a locus in tumor suppression and cell mortality
-
Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA: Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27-37, 1996
-
(1996)
Cell
, vol.85
, pp. 27-37
-
-
Serrano, M.1
Lee, H.2
Chin, L.3
Cordon-Cardo, C.4
Beach, D.5
DePinho, R.A.6
-
35
-
-
0029670840
-
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence
-
Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G: Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol 16: 859-67, 1996
-
(1996)
Mol Cell Biol
, vol.16
, pp. 859-867
-
-
Hara, E.1
Smith, R.2
Parry, D.3
Tahara, H.4
Stone, S.5
Peters, G.6
-
36
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC: Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 93: 13742-7, 1996
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
37
-
-
0030612349
-
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
-
Zindy F, Quelle DE, Roussel MF, Sherr CJ: Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15: 203-11, 1997
-
(1997)
Oncogene
, vol.15
, pp. 203-211
-
-
Zindy, F.1
Quelle, D.E.2
Roussel, M.F.3
Sherr, C.J.4
-
38
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ: Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649-59, 1997
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
Quelle, D.E.4
Downing, J.R.5
Ashmun, R.A.6
Grosveld, G.7
Sherr, C.J.8
-
39
-
-
0030876483
-
Induction of senescence in human malignant glioma cells by p16INK4A
-
Uhrbom L, Nister M, Westermark B: Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene 15: 505-14, 1997
-
(1997)
Oncogene
, vol.15
, pp. 505-514
-
-
Uhrbom, L.1
Nister, M.2
Westermark, B.3
-
40
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein GH, Drullinger LF, Soulard A, Dulic V: Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 19: 2109-17, 1999
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
41
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602, 1997
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
42
-
-
0033562997
-
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function
-
Kamijo T, van de Kamp E, Chong MJ, Zindy F, Diehl JA, Sherr CJ, McKinnon PJ: Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Cancer Res 59: 2464-9, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 2464-2469
-
-
Kamijo, T.1
Van De Kamp, E.2
Chong, M.J.3
Zindy, F.4
Diehl, J.A.5
Sherr, C.J.6
McKinnon, P.J.7
-
43
-
-
0033622003
-
p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
-
Carnero A, Hudson JD, Price CM, Beach DH: p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Nat Cell Biol 2: 148-55, 2000
-
(2000)
Nat Cell Biol
, vol.2
, pp. 148-155
-
-
Carnero, A.1
Hudson, J.D.2
Price, C.M.3
Beach, D.H.4
-
44
-
-
0033522231
-
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
-
Schreiber M, Muller WJ, Singh G, Graham FL: Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene 18: 1663-76, 1999
-
(1999)
Oncogene
, vol.18
, pp. 1663-1676
-
-
Schreiber, M.1
Muller, W.J.2
Singh, G.3
Graham, F.L.4
-
45
-
-
0033624150
-
Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein
-
Kim M, Katayose Y, Rojanala L, Shah S, Sgagias M, Jang L, Jung YJ, Lee SH, Hwang SG, Cowan KH: Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein. Cell Death Differ 7: 706-711, 2000
-
(2000)
Cell Death Differ
, vol.7
, pp. 706-711
-
-
Kim, M.1
Katayose, Y.2
Rojanala, L.3
Shah, S.4
Sgagias, M.5
Jang, L.6
Jung, Y.J.7
Lee, S.H.8
Hwang, S.G.9
Cowan, K.H.10
-
46
-
-
0033569422
-
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
-
Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL: Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 13: 2658-69, 1999
-
(1999)
Genes Dev
, vol.13
, pp. 2658-2669
-
-
Eischen, C.M.1
Weber, J.D.2
Roussel, M.F.3
Sherr, C.J.4
Cleveland, J.L.5
-
47
-
-
0033569423
-
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
-
Schmitt CA, McCurrach ME, de Stanchina E, Wallace-Brodeur RR, Lowe SW: INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev 13: 2670-7, 1999
-
(1999)
Genes Dev
, vol.13
, pp. 2670-2677
-
-
Schmitt, C.A.1
McCurrach, M.E.2
De Stanchina, E.3
Wallace-Brodeur, R.R.4
Lowe, S.W.5
-
48
-
-
0030726538
-
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro
-
Chintala SK, Fueyo J, Gomez-Manzano C, Venkaiah B, Berkvig R, Yung WK, Sawaya R, Kyritsis AP, Rao JS: Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene 15: 2049-57, 1997
-
(1997)
Oncogene
, vol.15
, pp. 2049-2057
-
-
Chintala, S.K.1
Fueyo, J.2
Gomez-Manzano, C.3
Venkaiah, B.4
Berkvig, R.5
Yung, W.K.6
Sawaya, R.7
Kyritsis, A.P.8
Rao, J.S.9
-
49
-
-
0033561310
-
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts
-
Fahraeus R, Lane DP: The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. Embo J 18: 2106-18, 1999
-
(1999)
Embo J
, vol.18
, pp. 2106-2118
-
-
Fahraeus, R.1
Lane, D.P.2
-
50
-
-
0029996913
-
The role of alpha v-integrins in tumour progression and metastasis
-
Marshall JF and Hart IR: The role of alpha v-integrins in tumour progression and metastasis. Semin Cancer Biol 7: 129-38, 1996
-
(1996)
Semin Cancer Biol
, vol.7
, pp. 129-138
-
-
Marshall, J.F.1
Hart, I.R.2
-
51
-
-
0032572566
-
Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: Comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and theproto-oncogene Bax
-
van Lookeren Campagne M, Gill R: Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and theproto-oncogene Bax. J Comp Neurol 397: 181-98, 1998
-
(1998)
J Comp Neurol
, vol.397
, pp. 181-198
-
-
Van Lookeren Campagne, M.1
Gill, R.2
-
52
-
-
0032526830
-
Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development
-
Watanabe G, Pena P, Shambaugh GE 3rd, Haines GK 3rd, Pestell RG: Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development. Brain Res Dev Brain Res 108: 77-87, 1998
-
(1998)
Brain Res Dev Brain Res
, vol.108
, pp. 77-87
-
-
Watanabe, G.1
Pena, P.2
Shambaugh G.E. III3
Haines G.K. III4
Pestell, R.G.5
-
53
-
-
0032589106
-
Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues
-
Nielsen GP, Stemmer-Rachamimov AO, Shaw J, Roy JE, Koh J, Louis DN: Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab Invest 79: 1137-43, 1999
-
(1999)
Lab Invest
, vol.79
, pp. 1137-1143
-
-
Nielsen, G.P.1
Stemmer-Rachamimov, A.O.2
Shaw, J.3
Roy, J.E.4
Koh, J.5
Louis, D.N.6
-
54
-
-
0031030325
-
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
-
Quelle DE, Cheng M, Ashmun RA, Sherr CJ: Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. Proc Natl Acad Sci USA 94: 669-73, 1997
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 669-673
-
-
Quelle, D.E.1
Cheng, M.2
Ashmun, R.A.3
Sherr, C.J.4
-
55
-
-
0032418416
-
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
-
Holland EC, Hively WP, DePinho RA, Varmus HE: A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12: 3675-85, 1998
-
(1998)
Genes Dev
, vol.12
, pp. 3675-3685
-
-
Holland, E.C.1
Hively, W.P.2
DePinho, R.A.3
Varmus, H.E.4
-
56
-
-
0032517341
-
The p16INK4a/CDKN2A tumor suppressor and its relatives
-
Ruas M, Peters G: The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1378: F115-77, 1998
-
(1998)
Biochim Biophys Acta
, vol.1378
-
-
Ruas, M.1
Peters, G.2
-
57
-
-
0031991891
-
Tumor suppressor p16INK4A: Determination of solution structure and analyses of its interaction with cyclin-dependent kinase
-
Byeon IJ, Li J, Ericson K, Selby TL, Tevelev A, Kim HJ, O'Maille P, Tsai MD: Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase. Mol Cell 1: 421-31, 1998
-
(1998)
Mol Cell
, vol.1
, pp. 421-431
-
-
Byeon, I.J.1
Li, J.2
Ericson, K.3
Selby, T.L.4
Tevelev, A.5
Kim, H.J.6
O'Maille, P.7
Tsai, M.D.8
-
58
-
-
9444276546
-
Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: Analysis of a clinic-based population
-
Fitz Gerald MG, Harkin DP, Silva-Arrieta S, MacDonald DJ, Lucchina LC, Unsal H, O'Neill E, Koh J, Finkelstein DM, Isselbacher KJ: Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population. Proc Natl Acad Sci USA 93: 8541-5, 1996
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8541-8545
-
-
Fitz Gerald, M.G.1
Harkin, D.P.2
Silva-Arrieta, S.3
MacDonald, D.J.4
Lucchina, L.C.5
Unsal, H.6
O'Neill, E.7
Koh, J.8
Finkelstein, D.M.9
Isselbacher, K.J.10
-
59
-
-
0029011539
-
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1: 686-92, 1995
-
(1995)
Nat Med
, vol.1
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
Lee, D.J.4
Gabrielson, E.5
Burger, P.C.6
Baylin, S.B.7
Sidransky, D.8
-
60
-
-
0033985151
-
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status
-
Esteller M, Tortola S, Toyota M, Capella G, Peinado MA, Baylin SB, Herman JG: Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 60: 129-33, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 129-133
-
-
Esteller, M.1
Tortola, S.2
Toyota, M.3
Capella, G.4
Peinado, Ma.5
Baylin, S.B.6
Herman, J.G.7
-
61
-
-
0343012076
-
Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas
-
Melendez B, Malumbres M, de Castro IP, Santos J, Pellicer A, Fernandez-Piqueras J: Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas. Carcinogenesis 21: 817-21, 2000
-
(2000)
Carcinogenesis
, vol.21
, pp. 817-821
-
-
Melendez, B.1
Malumbres, M.2
De Castro, I.P.3
Santos, J.4
Pellicer, A.5
Fernandez-Piqueras, J.6
-
62
-
-
0028618304
-
Deletion of p16 and p15 genes in brain tumors
-
Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B: Deletion of p16 and p15 genes in brain tumors. Cancer Res 54: 6353-8, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 6353-6358
-
-
Jen, J.1
Harper, J.W.2
Bigner, S.H.3
Bigner, D.D.4
Papadopoulos, N.5
Markowitz, S.6
Willson, J.K.7
Kinzler, K.W.8
Vogelstein, B.9
-
63
-
-
0028652269
-
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the ma ority of glioblastomas
-
Schmidt EE, Ichimura K, Reifenberger G, Collins VP: CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the ma ority of glioblastomas. Cancer Res 54: 6321-4, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 6321-6324
-
-
Schmidt, E.E.1
Ichimura, K.2
Reifenberger, G.3
Collins, V.P.4
-
64
-
-
0028970955
-
Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines
-
He J, Olson JJ, James CD: Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res 55: 4833-6, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 4833-4836
-
-
He, J.1
Olson, J.J.2
James, C.D.3
-
65
-
-
0029736653
-
Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene
-
Ichimura K, Schmidt EE, Goike HM, Collins VP: Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene. Oncogene 13: 1065-72, 1996
-
(1996)
Oncogene
, vol.13
, pp. 1065-1072
-
-
Ichimura, K.1
Schmidt, E.E.2
Goike, H.M.3
Collins, V.P.4
-
66
-
-
0034649787
-
Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
-
Ichimura K, Bolin MB, Goike HM, Schmidt EE, Moshref A, Collins VP: Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res 60: 417-24, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 417-424
-
-
Ichimura, K.1
Bolin, M.B.2
Goike, H.M.3
Schmidt, E.E.4
Moshref, A.5
Collins, V.P.6
-
67
-
-
0034601410
-
p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma
-
Fulci G, Labuhn M, Maier D, Lachat Y, Hausmann O, Hegi ME, Janzer RC, Merlo A, Van Meir EG: p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma. Oncogene 19: 3816-22, 2000
-
(2000)
Oncogene
, vol.19
, pp. 3816-3822
-
-
Fulci, G.1
Labuhn, M.2
Maier, D.3
Lachat, Y.4
Hausmann, O.5
Hegi, M.E.6
Janzer, R.C.7
Merlo, A.8
Van Meir, E.G.9
-
68
-
-
0030665667
-
Retinoic acid and the cyclin dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells
-
Dirks PB, Patel K, Hubbard SL, Ackerley C, Hamel PA, Rutka JT: Retinoic acid and the cyclin dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells. Oncogene 15: 2037-48, 1997
-
(1997)
Oncogene
, vol.15
, pp. 2037-2048
-
-
Dirks, P.B.1
Patel, K.2
Hubbard, S.L.3
Ackerley, C.4
Hamel, P.A.5
Rutka, J.T.6
-
69
-
-
0030033729
-
Adenovirus- Mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells
-
Fueyo J, Gomez-Manzano C, Yung WK, Clayman GL, Liu TJ, Bruner J, Levin VA, Kyritsis AP: Adenovirus- mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 12: 103-10, 1996
-
(1996)
Oncogene
, vol.12
, pp. 103-110
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Yung, W.K.3
Clayman, G.L.4
Liu, T.J.5
Bruner, J.6
Levin, V.A.7
Kyritsis, A.P.8
-
70
-
-
0031868324
-
Restoration of growth arrest by p16INK4, p21WAF1, pRB, and p53 is dependent on the integrity of the endogenous cell-cycle control pathways in human glioblastoma cell lines
-
Costanzi-Strauss E, Strauss BE, Naviaux RK, Haas M: Restoration of growth arrest by p16INK4, p21WAF1, pRB, and p53 is dependent on the integrity of the endogenous cell-cycle control pathways in human glioblastoma cell lines. Exp Cell Res 238: 51-62, 1998
-
(1998)
Exp Cell Res
, vol.238
, pp. 51-62
-
-
Costanzi-Strauss, E.1
Strauss, B.E.2
Naviaux, R.K.3
Haas, M.4
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