Biogenesis and function of peroxisomes and glycosomes

Molecular and Biochemical Parasitology

Volumn 115, Issue 1, 2001, Pages 19-28

  Parsons, Marilyn ^a,b   Furuya, Tetsuya ^a,b   Pal, Sampa ^a,b   Kessler, Peter ^a,b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Glycolysis; Leishmania; Protein import; Trypanosoma

Indexed keywords

CELL PROTEIN; ETHER LIPID; ISOPRENOID; MATRIX PROTEIN; PEROXIN;

BIOGENESIS; BIOSYNTHESIS; CELL COMPARTMENTALIZATION; CELL LINEAGE; CELL ORGANELLE; DEACYLATION; DRUG TARGETING; EUKARYOTE; FATTY ACID OXIDATION; FLAGELLATE; GLYCOLYSIS; LIPOGENESIS; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW;

ANIMALS; LEISHMANIA; MICROBODIES; PEROXISOMES; PROTOZOAN PROTEINS; TRYPANOSOMA;

EUKARYOTA; KINETOPLASTIDA; PROTOZOA; TRYPANOSOMA;

EID: 0035010097     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(01)00261-4     Document Type: Review

References (86)

1. Compartmentation of carbohydrate metabolism in trypanosomes
2. Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: The glycosome
3. Cell and genome coevolution: Facultative anaerobiosis, glycosomes and kinetoplastan RNA editing
4. The evolution of kinetoplastid glycosomes
5. Proteins involved in peroxisome biogenesis and functioning
6. Peroxisomal disorders: Overview
7. Hepatocarcinogenesis of peroxisome proliferators
8. Demonstration of glycosomes (microbodies) in the Bodonid flagellate Trypanoplasma borelli (Protozoa, Kinetoplastida)
9. Identification of glycosomes and metabolic end products in pathogenic and nonpathogenic strains of Crytobia salmositica (Kinetoplastida: Bodonidae)
10. Targeting and subcellular localization of Toxoplasma gondii catalase. Identification of peroxisomes in an apicomplexan parasite
11. Toxoplasma gondii catalase: Are there peroxisomes in toxoplasma?
12. Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei
13. Import of peroxisomal matrix and membrane proteins
14. Conserved tripeptide sorts proteins to peroxisomes
15. In vivo import of firefly luciferase into the glycosomes of Trypanosoma brucei and mutational analysis of the C-terminal targeting signal
16. A novel, cleavable peroxisomal targeting signal at the amino- terminus of the rat 3-ketoacyl-CoA thiolase
17. Function of N-terminal import signals in trypanosome microbodies
18. Evidence for a novel pathway for the targeting of a Saccharomyces cerevisiae peroxisomal protein belonging to the isomerase/hydratase family
19. Trypanosoma brucei: Identification of an internal region of phosphoglycerate kinase required for targeting to glycosomal microbodies
20. The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it
21. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins
22. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: Evidence that PTS1 protein import is mediated by a cycling receptor
23. A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris
24. Isolation and characterization of Chinese hamster ovary cell mutants defective in assembly of peroxisomes
25. Peroxisomal targeting signal-1 receptor protein PEX5 from Leishmania donovani. Molecular, biochemical, and immunocytochemical characterization
26. Cloning and analysis of the PTS-1 receptor in Trypanosoma brucei
27. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
28. The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene
29. The WD repeat: A common architecture for diverse functions
30. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p
31. Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
32. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways
33. Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery
34. Pex17p is required for import of both peroxisome membrane and lumenal proteins and interacts with Pex19p and the peroxisome targeting signal-receptor docking complex in Pichia pastoris
35. Saccharomyces cerevisiae PTS1 receptor pex5p interacts with the SH3 domain of the peroxisomal membrane protein pex13p in an unconventional, non-PXXP-related manner
36. Supercoiled protein motifs: The collagen triple-helix and the alpha-helical coiled coil
37. The RING finger domain: A recent example of a sequence-structure family
38. PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import
39. Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin
40. Import of stably folded proteins into peroxisomes
41. Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer
42. An oligomeric protein is imported into peroxisomes in vivo
43. An internal region of the peroxisomal membrane protein PMP47 is essential for sorting to peroxisomes
44. Identification and characterization of the human peroxin PEX3
45. The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop
46. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S. cerevisiae, causes proliferation of the endoplasmic reticulum membrane
47. Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins
48. Peroxisome synthesis in the absence of preexisting peroxisomes
49. The peroxin pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane
50. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis
51. Biogenesis of peroxisomes
52. Mutants of the yeast Yarrowia lipolytica defective in protein exit from the endoplasmic reticulum are also defective in peroxisome biogenesis
53. Peroxisome biogenesis: Involvement of ARF and coatomer
54. Brefeldin A interferes with peroxisomal protein sorting in the yeast Hansenula polymorpha
55. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis
56. Fusion of small peroxisomal vesicles in vitro reconstructs an early step in the in vivo multistep peroxisome assembly pathway of Yarrowia lipolytica
57. The peroxisome biogenesis factors Pex4p, Pex22p, Pex1p, and Pex6p act in the terminal steps of peroxisomal matrix protein import
58. Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes
59. Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p
60. Comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei blood stream form and cultured procyclic trypomastigotes
61. Compartmentation protects trypanosomes from the dangerous design of glycolysis
62. Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism
63. What controls glycolysis in bloodstream form Trypanosoma brucei?
64. Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases
65. A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana
66. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase
67. Functions and organization of peroxisomal beta-oxidation
68. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions
69. Transport of activated fatty acids by the peroxisomal ATP-binding-cassette transporter Pxa2 in a semi-intact yeast cell system
70. Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiae
71. Metabolic control of peroxisome abundance
72. The dihydroxyacetonephosphate pathway for biosynthesis of ether lipids in Leishmania mexicana promastigotes
73. Lipid biosynthesis in peroxisomes
74. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research
75. The lipophosphoglycan of Leishmania parasites
76. Glycoinositol-phospholipid profiles of four serotypically distinct Old World Leishmania strains
77. The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei
78. Short-course of oral miltefosine for treatment of visceral leishmaniasis
79. Cell compartmentalization of cholesterol biosynthesis
80. 3-hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: Subcellular localization and kinetic properties
81. Localisation of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the mitochondrial matrix of Trypanosoma brucei procyclics
82. Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)
83. Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies
84. Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis
85. Genetic analysis of purine metabolism in Leishmania donovani
86. Isolation and characterization of Leishmania mutants defective in glycosomal protein imports