The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei

Journal of Antimicrobial Chemotherapy

Volumn 38, Issue 6, 1996, Pages 1041-1047

  Croft, Simon L ^a   Snowdon, Diane ^a   Yardley, Vanessa ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLLYSOPHOSPHOLIPID; ANTINEOPLASTIC AGENT; EDELFOSINE; ILMOFOSINE; MILTEFOSINE; SRI 62834;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; FEMALE; LEISHMANIA DONOVANI; LEISHMANIASIS; MOUSE; NONHUMAN; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS; TRYPOMASTIGOTE;

ANIMALS; ANTINEOPLASTIC AGENTS; CHAGAS DISEASE; CRICETINAE; FEMALE; FURANS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; PHOSPHOLIPID ETHERS; PHOSPHORYLCHOLINE; RATS; RATS, SPRAGUE-DAWLEY; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS, AFRICAN;

EID: 0030481123     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/38.6.1041     Document Type: Article

References (10)

1. Achterberg, V. & Gercken, G. (1987a). Cytotoxicity of ester and ether lysophospholipids on Leishmania donovani promastigotes. Molecular and Biochemical Parasitology 23, 117-22.
2. Achterberg, V. & Gercken, G. (1987b). Metabolism of ether lysophospholipids in Leishmania donovani promastigotes. Molecular and Biochemical Parasitology 26, 277-87.
3. Adinolfi, L. E. & Bonventre, P. F. (1985). Enhancement of Glucantime therapy of murine Leishmania donovani infection by a synthetic immunopotentiating compound (CP-46,665-1). American Journal of Tropical Medicine and Hygiene 34, 270-7.
4. Berdel, W. E. (1991). Membrane-interactive lipids as experimental anticancer drugs. British Journal of Cancer 64, 208-11.
5. Brachwitz, H. & Vollgraf, C. (1995). Analogs of alkyllysophospholipids: chemistry, effects on the molecular level and their consequences for normal and malignant cells. Pharmacology and Therapeutics 66, 39-82.
6. Croft, S. L., Neal, R. A., Pendergast, W. & Chan, J. H. (1987). The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani. Biochemical Pharmacology 36, 2633-6.
7. Croft, S. L., Neal, R. A., Thornton, E. A. & Herrmann, D. B. J. (1993). Antileishmanial activity of the ether phospholipid ilmofosine. Transactions of the Royal Society of Tropical Medicine and Hygiene 87, 217-9.
8. Haughan, P. A. & Goad, L. J. (1991). Lipid biochemistry of trypanosomatids. In Biochemical Protozoology, (Coombs,G. H. & North, M. J., Eds), pp. 312-8. Taylor & Francis, London.
9. Jernigan, J. A. & Pearson, R. D. (1993). Chemotherapy of leishmaniasis, Chagas' disease and African trypanosomiasis. Current Opinion in Infectious Diseases 6, 794-802.
10. Kuhlencord, A., Maniera, T., Eibl, H. & Unger, C. (1992). Hexadecylphosphocholine: oral treatment of visceral leishmaniasis in mice. Antimicrobial Agents and Chemotherapy 36, 1630-4.