Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 8, 1999, Pages 4273-4278

  Aronov, Alex M ^a,d   Suresh, Stephen ^a   Buckner, Frederick S ^a   Van Voorhis, Wesley C ^a   Verlinde, Christophe L M J ^a   Opperdoes, Fred R ^c   Hol, Wim G J ^a   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c International Institute of Cellular and Molecular Pathology   (Belgium)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DERIVATIVE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOLYTIC ENZYME; PYRUVIC ACID;

ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; ENZYME ASSAY; ENZYME INHIBITION; GLYCOLYSIS; LEISHMANIA; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SOLUBILITY; STRUCTURE ANALYSIS; TRYPANOSOMA BRUCEI;

3T3 CELLS; ADENOSINE; ANIMALS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GLYCOLYSIS; HUMANS; LEISHMANIA MEXICANA; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0033551233     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.8.4273     Document Type: Article

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