Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery

Journal of Cell Biology

Volumn 140, Issue 1, 1998, Pages 49-60

  Huhse, Bettina ^b   Rehling, Peter ^a   Albertini, Markus ^a   Blank, Lars ^a   Meller, Karl ^a   Kunau, Wolf H ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX PROTEIN; MEMBRANE PROTEIN;

ARTICLE; NONHUMAN; PEROXISOME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; CARRIER PROTEINS; CLONING, MOLECULAR; DNA PRIMERS; FUNGAL PROTEINS; GENOTYPE; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROBODIES; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0031953256     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.140.1.49     Document Type: Article

References (58)

1. Albertini, M., P. Rehling, R. Erdmann, W. Girzalsky, J.A.K.W Kiel, M. Veenhuis, and W.-H Kunau. 1997. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell. 89: 83-92.
2. Ausubel, F.J., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1992. Current Protocols in Molecular Biology. Greene Publishing Associates, New York.
3. Blobel, F., and R. Erdmann. 1996. Identification of a peroxisomal member of the AMP-binding protein family. Eur. J. Biochem. 240:468-476.
4. Chevray, P.M., and D. Nathans. 1992. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci. USA. 89:5789-5793.
5. Coster, F., L. Van Dyck, J.L. Jonniaux, B. Prunelle, and A. Goffeau. 1995. The sequence of a 13.5 kb DNA segment from the left arm of chromosome XIV reveals MER1; RAP1; a new putative member of the DNA replication complex and a new putative serine/threonine phosphatase gene. Yeast. 11:95-91.
6. Crane, D.I., J.E. Kalish, and S.J. Gould. 1994. The Pichia pastoris PAS4 gene encodes a ubiquitin-conjugation enzyme required for peroxisome assembly. J. Biol. Chem. 269:21835-21844.
7. De Hoop, M.J., and G. Ab. 1992. Import of proteins into peroxisomes and other microbodies. Biochem. J. 286:657-669.
8. Distel, B., R. Erdmann, S.J. Gould, G. Blobel, D.I. Crane, J.M. Cregg, G. Dodt, Y. Fujiki, J.M. Goodman, W.W. Just, et al. 1996. A unified nomenclature for peroxisome biogenesis. J. Cell Biol. 135:1-3.
9. Dodt, G., and S.J. Gould. 1996. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor. J. Cell Biol. 135: 1763-1774.
10. Einerhand, A.W.C., T.M. Voorn-Brouwer, R. Erdmann, W.-H. Kunau, and H.F. Tabak. 1991. Regulation of transcription of the gene coding for peroxisomal 3-oxoacyl CoA thiolase of Saccharomyces cerevisiae. Eur. J. Biochem. 200:113-122.
11. Eisenberg, E., E. Schwarz, M. Komaromy, and R. Wall. 1984. Analysis of membrane and surface protein sequences with the hydrophobic moment plot. J. Mol. Biol. 179:125-142.
12. Elgersma, Y., and H.F. Tabak. 1996. Proteins involved in peroxisome biogenesis and functioning. Biochim. Biophys. Acta. 1286(3):269-283.
13. Elgersma, Y., L. Kwast, A. Klein, T. Voorn-Brouwer, M. van den Berg, B. Metzig, T. America, H.F. Tabak, and B. Distel. 1996. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import of PTS1 containing proteins. J. Cell Biol. 135:97-109.
14. Erdmann, R. 1994. The peroxisomal targeting signal of 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae. Yeast. 10:935-944.
15. Erdmann, R., and G. Blobel. 1995. Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. J. Cell Biol. 128:509-523.
16. Erdmann, R., and G. Blobel. 1996. Identification of a peroxisomal membrane receptor for the COOH-terminal tripeptide signal recognition factor. J. Cell Biol. 135:111-121.
17. Erdmann, R., and W.-H. Kunau. 1994. Purification and immunolocalization of the peroxisomal 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae. Yeast. 10:1173-1182.
18. Erdmann, R., M. Veenhuis, D. Mertens, and W.-H. Kunau. 1989. Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 86:5419-5423.
19. Erdmann, R., M. Veenhuis, and W.-H. Kunau. 1997. Peroxisomes: organelles at the cross-road. Trends Cell Biol. 7:400-407.
20. Fields, S., and O.K. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature. 340:245-246.
21. Fujiki, Y., A.L. Hubbard, S. Fowler, and P.B. Lazarow. 1982. Isolation of intracellular membranes by means of sodium carbonate treatment: applications to the endoplasmic reticulum. J. Cell Biol. 93:97-102
22. Gietz, R.D., and A. Sugino. 1988. New yeast-E coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene. 74:527-534.
23. Gould, S.J., G.A. Keller, N. Hosken, J. Wilkinson, and S. Subramani. 1989. A conserved tripeptide sorts proteins to peroxisomes. J. Cell Biol. 108:1657-1664.
24. Gould, S.J., J.E. Kalish, J.C. Morrell, J.B. Jorkman, A.J. Urquhart, and D.I. Crane. 1996. An SH3 protein in the peroxisome membrane is a docking factor for the PTS1 receptor. J. Cell Biol. 135:85-95.
25. Harlow, E., and D. Lane. 1988. Antibodies - A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
26. Höhfeld, J., M. Veenhuis, and W.H. Kunau. 1991. PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis. J. Cell Biol. 114:1167-1178.
27. Höhfeld, J., D. Mertens, F.F. Wiebel, and W.-H. Kunau. 1992. Defining components required for peroxisome assembly in Saccharomyces cerevisiae. In New Comprehensive Biochemistry Series: Membrane Biogenesis and Protein Targeting. W. Neupert and R. Lill, editors. Elsevier Science Publishing Co., New York. 185-207.
28. Jones, J.S., and L. Prakash. 1990. Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast. 6:363-366.
29. Klein, P., M. Kanehisa, and C. DeLisi. 1985. The detection and classification of membrane-spanning proteins. Biochim. Biophys. Acta. 815:468-476.
30. Komori, M., S.W. Rasmussen, J.A.K.W. Kiel, R.J.S. Baerends, J.M. Cregg, I.J. van der Klei, and M. Veenhuis. 1996. The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein involved in matrix protein import. EMBO (Eur. Mol. Biol. Organ.) J. 16:44-53.
31. Kragler, F., A. Langeder, J. Raupachova, M. Binder, and A. Hartig. 1993. Two independent peroxisomal targeting signals in catalase A of Saccharomyces cerevisiae. J. Cell Biol. 120:665-673.
32. Kunau, W.-H., A. Beyer, T. Franken, K. Götte, M. Marzioch, J. Saidowsky, A. Skaletz-Rorowski, and F.F. Wiebel. 1993. Two complementary approaches to study peroxisome biogenesis in Saccharomyces cerevisiae: forward and reversed genetics. Biochimie (Paris). 75:209-224.
33. Kyte, J., and R.F. Doolittle. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.
34. Lazarow, P.B., and Y. Fujiki. 1985. Biogenesis of peroxisomes. Annu. Rev. Cell Biol. 1:489-530.
35. Lupas, A. 1996. Prediction and analysis of coiled-coil structures. Methods Enzymol. 266:513-525.
36. Marshall, P.A., Y.I. Krimkevich, R.H. Lark, J.M. Deyer, M. Veenhuis, and J.M. Goodman. 1995. PMP27 promotes peroxisome proliferation. J. Cell Biol. 129:345-355.
37. Marzioch, M., R. Erdmann, M. Veenhuis, and W.-H. Kunau. 1994. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes. EMBO (Eur. Mol. Biol. Organ.) J. 13:4908-4918.
38. McNew, J.A., and J.M. Goodman. 1996. The targeting and assembly of peroxisomal proteins: some old rules do not apply. Trends Biochem. Sci. 21:54-58.
39. Moreno de la Garza, M., U. Schulz-Borchard, J.W. Crabb, and W.H. Kunau. 1985. Peroxisomal β-oxidation system of Candida tropicalis. Eur. J. Biochem. 148:285-291.
40. Motley, A., E. Hettema, B. Distel, and H. Tabak. 1994. Differential protein import deficiencies in human peroxisome assembly disorders. J. Cell Biol. 125: 755-767.
41. Purdue, P.E., and P.B. Lazarow. 1995. Identification of peroxisomal membrane ghosts with an epitope-tagged integral membrane protein in yeast mutants lacking peroxisomes. Yeast. 11:1045-1060.
42. Rachubinski, R.A., and S. Subramani. 1995. How to penetrate peroxisomes. Cell. 83:525-528.
43. Rehling, P., M. Albertini, and W.-H. Kunau. 1996a. Protein import into peroxisomes: new developments. In Peroxisomes: Biology and Role in Toxicology and Disease. Ann. NY Acad. Sci. 804:34-16.
44. Rehling, P., M. Marzioch, F. Niesen, E. Wittke, M. Veenhuis, and W.-H. Kunau. 1996b. The import receptor for the peroxisomal targeting signal 2 PTS2 in Saccharomyces cerevisiae is encoded by the PAS7 gene. EMBO (Eur. Mol. Biol. Organ.) J. 15:2901-2913.
45. Remaut, E., P. Stanssens, and W. Fiers. 1981. Plasmid vectors for high-efficiency expression controlled by the pL promotor of coliphage Lambda. Gene. 15:81-93.
46. Roa, M.J.K., and P. Argos. 1986. A conformational preference parameter to predict helices in integral membrane proteins. Biochim. Biophys. Acta. 869: 197-214.
47. Rose, M.D., P. Novick, J.H. Thomas, D. Botstein, and G.R. Fink. 1987. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene. 60:237-243.
48. Rout, M.P., and J.V. Kilmartin. 1990. Components of the yeast spindle pole body. J. Cell. Biol. 111:1913-1927.
49. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
50. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:5463-5467.
51. Sherman, F., G.R. Fink, and C.W. Lawrence. 1979. Methods in Yeast Genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
52. Slawecki, M.L., G. Dodt, S. Steinberg, A.B. Moser, H. Moser, and S.J. Gould. 1995. Identification of three distinct peroxisomal protein import defects in patients with peroxisome biogenesis disorders. J. Cell Sci. 108:1817-1829.
53. Subramani, S. 1993. Protein import into peroxisomes and biogenesis of the organelle. Annu. Rev. Cell Biol. 9:445-478.
54. Subramani, S. 1996. Protein translocation into peroxisomes. J. Biol. Chem. 271: 32483-32486.
55. Subramani, S. 1997. PEX genes on the rise. Nat. Genet. 15:331-332.
56. Veenhuis, M., M. Mateblowski, W.-H. Kunau, and W. Harder. 1987. Proliferation of microbodies in Saccharomyces cerevisiae. Yeast. 3:77-84.
57. Wach, A., A. Brachat, R. Poehlmann, and P. Philippsen. 1994. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast. 10:1793-1808.
58. Wiebel, F.F., and W.-H. Kunau. 1992. The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature. 359:73-76.