The peroxisome biogenesis factors Pex4p, Pex22p, Pex1p, and Pex6p act in the terminal steps of peroxisomal matrix protein import

Molecular and Cellular Biology

Volumn 20, Issue 20, 2000, Pages 7516-7526

  Collins, C S ^a   Kalish, J E ^a   Morrell, J C ^a   McCaffery, J M ^a   Gould, S J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX PROTEIN; PEROXISOME BIOGENESIS FACTOR; PEROXISOME BIOGENESIS FACTOR PEX1P; PEROXISOME BIOGENESIS FACTOR PEX22P; PEROXISOME BIOGENESIS FACTOR PEX4P; PEROXISOME BIOGENESIS FACTOR PEX6P; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; FUNGUS MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PHENOTYPE; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; TRANSMISSION ELECTRON MICROSCOPY;

ADENOSINETRIPHOSPHATASE; BLOTTING, WESTERN; CARRIER PROTEINS; CENTRIFUGATION, DENSITY GRADIENT; EPISTASIS, GENETIC; FUNGAL PROTEINS; GLYCOPROTEINS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; MUTATION; PEROXISOMES; PHENOTYPE; PICHIA; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; UBIQUITINS;

EID: 0033800536     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.20.7516-7526.2000     Document Type: Article

References (50)

1. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways
2. Metabolic control of peroxisome abundance
3. PEX12 binds PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import
4. The Pichia pastoris HIS4 gene: Nucleotide sequence, creation of a non-reverting his4 deletion mutant, and development of HIS4-based replicating and integrating plasmids
5. The Pichia pastoris PAS4 gene encodes a ubiquitin-conjugating enzyme required for peroxisome assembly
6. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders
7. Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: Evidence that PTS1 protein import is mediated by a cycling receptor
8. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import of PTS1 containing proteins
9. Identification of Pex13p, a peroxisomal membrane receptor for the PTS1 recognition factor
10. Two AAA family proteins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes
11. Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import
12. Disruption of a PEX1-PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease
13. 2-enoyl-CoA isomerase
14. Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
15. PEX13p is an SH3 protein in the peroxisome membrane and a docking factor for the PTS1 receptor
16. A conserved tripeptide sorts proteins to peroxisomes
17. Development of the yeast Pichia pastoris as a model organism for a genetic and molecular analysis of peroxisome assembly
18. Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants
19. Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins
20. Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis
21. PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis
22. Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery
23. Formation of the peroxisome lumen is abolished by loss of Pichia pastoris Pas7p, a zinc-binding integral membrane protein of the peroxisome
24. Characterization of a novel component of the peroxisomal protein import apparatus using fluorescent peroxisomal proteins
25. Hansenula polymorpha Pex1p and Pex6p are peroxisome-associated AAA proteins that functionally and physically interact
26. Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme. Pex4p, on the peroxisomal membrane
27. Biogenesis of peroxisomes
28. PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes
29. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly
30. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells. The PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal and is a member of the TPR protein family
31. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes
32. The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene
33. Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes, binds the PTS1 receptor pex5p
34. Mutations in PEX1 are the most common cause of the peroxisome biogenesis disorders
35. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis
36. Identification of three distinct peroxisomal protein import defects in patients with peroxisomal biogenesis disorders
37. Pex17p is required for import of both peroxisome membrane and lumenal proteins and interacts with Pex19p and the peroxisome targeting signal-receptor docking complex in Pichia pastoris
38. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis
39. Cloning and characterization of PAS5: A gene required for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris
40. Protein import into peroxisomes and biogenesis of the organelle
41. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase
42. Peroxisomes: Simple function but complex in maintenance
43. Fusion of small peroxisomal vesicles in vitro reconstructs an early step in the in vivo multi-step peroxisome assembly pathway of Yarrowia lipolytica
44. The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery
45. The Hansenula polymorpha PER3 gene is essential for the import of PTS1 proteins into the peroxisome matrix
46. Peroxisomes in the methyltrophic yeast Hansenula polymorpha do not necessarily derive from pre-existing organelles
47. The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes
48. Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris
49. The peroxisome biogenesis disorder group 4 gene, PXAAA1, encodes a cytoplasmic ATPase required for stability of the PTS1 receptor