Prevention of autoimmune destruction of syngeneic islet grafts in spontaneously diabetic nonobese diabetic mice by a combination of a vitamin D3 analog and cyclosporine

Transplantation

Volumn 65, Issue 9, 1998, Pages 1225-1232

  Casteels, Kristina ^a   Waer, Mark ^a   Laureys, Jos ^a   Valckx, Dirk ^a   Depovere, Jos ^a   Bouillon, Roger ^a   Mathieu, Chantal ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b LEGENDO   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

COLECALCIFEROL DERIVATIVE; CYCLOSPORIN; LEXACALCITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HELPER CELL; HISTOPATHOLOGY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL;

ANIMALS; AUTOIMMUNITY; CALCITRIOL; CALCIUM; CHOLECALCIFEROL; CYCLOSPORINE; DIABETES MELLITUS; DRUG COMBINATIONS; IMMUNOSUPPRESSIVE AGENTS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED NOD; RECURRENCE; TRANSPLANTATION, ISOGENEIC;

EID: 0032525285     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199805150-00014     Document Type: Article

References (35)

1. Carnaud C, Bach JF. Cellular basis of T-cell autoreactivity in autoimmune diseases. Immunol Res 1993; 12: 131.
2. Lacy P. Status of islet cell transplantation. Diabetes Rev 1993; 1: 76.
3. Robertson RP. Pancreatic and islet transplantation for diabetes: cures or curiosities. N Engl J Med 1992; 327: 1861.
4. Sutherland D, Goetz F, Najarian J. Pancreas transplants from related donors. Transplantation 1984; 38: 625.
5. Tyden G, Reinholt F, Sundkvist G, Bolinder J. Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. N Engl J Med 1996; 335: 860.
6. Matsuo S, Mulen Y, Wickler L, et al. Prolongation of islet isograft survival in diabetic NOD mice by anti-L3T4 and anti-Lyt2 monoclonal antibodies. Transplant Proc 1990; 22: 880.
7. Wang Y, Pontesilli O, Gill R, La Rosa F, Lafferty K. The role of CD4 and CD8 T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc Natl Acad Sci USA 1991; 88: 527.
8. Ricordi C, Tzakis A, Carroll P, et al. Human islet isolation and allotransplanatation in 22 consecutive cases. Transplantation 1992; 53: 407.9.
9. Sharp D, Lacy P, Santiago J, et al. Results of our first nine intraportal islet allografts in type I, insulin-dependent diabetic patients. Transplantation 1991; 51: 76.
10. Tzakis A, Ricordi C, Alejandro R, et al. Pancreatic islet transplantation after upper abdominal exenteration and liver replacement. Lancet 1990; 336: 402.
11. 3. Diabetologia 1994; 37: 552.
12. Mathieu C, Laureys J, Sobis H, Vandeputte M, Waer M, Bouillon R. 1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice. Diabetes 1992; 41: 1491.
13. 3, KH1060. Endocrinology 1995; 136: 866.
14. Branisteanu DD, Mathieu C, Casteels K, Bouillon R. Combination of vitamin D analogues and immunosuppressants: potential clinical use. Clin Immunother 1996; 6: 465.
15. Gepner P, Amor B, Fournier C. 1,25-dihydroxyvitamin D3 potentiates the in vitro inhibitory effect of cyclosporine A on T cells from rheumatoid arthritis patients. Arthritis Rheum 1989; 32: 31.
16. Mathieu C, Bouillon R, Rutgeerts O, Vandeputte M, Waer M. A potential role of 1,25(OH)2D3 as a dose reducing agent for cyclosporin and FK506. Transplant Proc 1994; 26: 3130.
17. Fournier C, Gepner P, Sadouk M, Charriere J. In vivo beneficial effects of cyclosporine A and 1,25-dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990; 54: 53.
18. Lillevang S, Rosenkvist J, Andersen J, Larsen S, Kemp E, Kristensen T. Single and combined effects of the vitamin D analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat. Clin Exp Immunol 1990; 88: 301.
19. Mathieu C, Laureys J, Waer M. Prevention of autoimmune destruction of transplanted islets in spontaneously diabetic NOD mice by KH1060, a 20-epi analog of vitamin D: synergy with cyclosporin A. Transplant Proc 1994; 26: 3128.
20. Casteels K, Waer M, Bouillon R, Allewaert K, Laureys J, Mathieu C. Prevention of type I diabetes by late intervention with nonhypercalcemic analogues of vitamin D in combination with cyclosporin A. Transplant Proc 1996; 28: 3095.
21. 3. J Neuroimmunol 1995; 61: 151.
22. Mandrup-Poulsen T, Helqvist S, Wogensen L, et al. Cytokines and free radicals as effector molecules in the destruction of pancreatic β cells. Curr Top Microbiol Immunol 1990; 164: 169.
23. Rabinovitch A. Roles of cytokines in IDDM pathogenesis and islet β cell destruction. Diabetes Rev 1993; 1: 215.
24. 3 in combination with a short induction course of cyclosporin A. Endocrinology 1998; 139: 95.
25. Pozzilli P, Signore A, Williams AJ, Beales P. NOD mouse colonies around the world: recent facts and figures. Immunol Today 1993; 14: 193.
26. Mathieu C, Kuttler B, Waer M, Bouillon R, Hahn H. Spontaneous reestablishment of self-tolerance in BB/PFD rats. Transplantation 1994; 58: 349.
27. Yalow R, Berson S. Immunoassay of endogeneous plasma insulin in man. J Clin Invest 1960; 39: 1157.
28. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156.
29. Heid C, Stevens J, Livak K, Williams P. Real time quantitative PCR. Genome Res 1996; 6: 986.
30. Gibson U, Heid C, Williams P. A novel method for real time quantitative RT-PCR. Genome Res 1996; 6: 995.
31. Fox C, Danska J. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice. J Immunol 1997; 158: 2414.
32. Verhaege J, Bouillon R, Lissens W, Visser W, Van Assche FA. Diabetes and low Ca-P diet have opposite effects on adult and fetal bone mineral metabolism. Am J Physiol 1988; 254: E496.
33. Katz I, Epstein S. Posttransplantation bone disease. J Bone Miner Res 1992; 7: 123.
34. Rabinovitch A, Sorensen O, Suarez-Pinzon W, Power R, Rajotte R, Bleackley R. Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival. Diabetologia 1994; 37: 833.
35. Shehadeh N, La Rosa F, Lafferty K. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J Autoimmun 1993; 6: 291.