Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor1 receptor antagonists: Aryl-1,2,3,6-tetrahydropyridino-purine, -3H-1,2,3-triazolo[4,5-d]pyrimidine, -purin-8-one, and -7H-pyrrolo[2,3-d]pyrimidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 5, 2001, Pages 1357-1363

  Kumagai, Toshihito ^a   Okubo, Taketoshi ^a   Kataoka Okubo, Hiromi ^a   Chaki, Shigeyuki ^a   Okuyama, Shigeru ^a   Nakazato, Atsuro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDROPYRIDINOPURINE; 1,2,3,6 TETRAHYDROPYRIDINOPYRIMIDINE DERIVATIVE; 2 METHYL 6 (4 PHENYL 1,2,3,6 TETRAHYDROPYRIDINO) 9 (2 BROMO 4 ISOPROPYLPHENYL)PURINE; 2 METHYL 6 [5 (2 METHYLPHENYL) 1,2,3,6 TETRAHYDROPYRIDINO] 9 (2 METHYLTHIO 4 ISOPROPYLPHENYL)PURINE; 2 METHYL 6 [5 (6 FLUOROPHENYL) 1,2,3,6 TETRAHYDROPYRIDINO] 9 (2 METHYLTHIO 4 ISOPROPYLPHENYL)PURINE; 2,7 DIMETHYL 6 [5 (2 METHYLPHENYL) 1,2,3,6 TETRAHYDROPYRIDINO] 9 (2 METHYLTHIO 4 ISOPROPYLPHENYL)PURINE 8 ONE; 3H 1,2,3 TRIAZOLO[4,5 D]PYRIMIDINE DERIVATIVE; 7H PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; LIGAND; PURIN 8 ONE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; PROTON TRANSPORT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AFFINITY LABELS; ANIMALS; DRUG DESIGN; FRONTAL LOBE; INHIBITORY CONCENTRATION 50; MYOCARDIUM; PROTEIN BINDING; PURINES; PYRIMIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034996649     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00005-0     Document Type: Article

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