Corticotropin-releasing hormone receptor antagonists: Framework design and synthesis guided by ligand conformational studies

Journal of Medicinal Chemistry

Volumn 42, Issue 5, 1999, Pages 819-832

  Hodge, C Nicholas ^a,b   Aldrich, Paul E ^a   Wasserman, Zelda R ^a   Fernandez, Christina H ^a   Nemeth, Gregory A ^a   Arvanitis, Argyrios ^a   Cheeseman, Robert S ^a   Chorvat, Robert J ^a   Ciganek, Engelbert ^a   Christos, Thomas E ^a   Gilligan, Paul J ^a   Krenitsky, Paul ^a,c   Scholfield, Everett ^a   Strucely, Philip ^a  

^a DUPONT COMPANY   (United States)

^b Caliper Life Sciences   (United States)

^c ARQULE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; MESYLIC ACID; METHYL GROUP; PYRIMIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG CONFORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIDINES; PYRIMIDINES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033545667     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980223o     Document Type: Article

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