Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3- d]pyrimidine: A centrally active corticotropin-releasing factor1 receptor antagonist

Journal of Medicinal Chemistry

Volumn 40, Issue 11, 1997, Pages 1749-1754

  Chen, Yuhpyng L ^a   Mansbach, Robert S ^a   Winter, Steven M ^a   Brooks, Elizabeth ^a   Collins, Judith ^a   Corman, Michael L ^a   Dunaiskis, Audrey R ^a   Faraci, W Stephen ^a   Gallaschun, Randall J ^a   Schmidt, Anne ^a   Schulz, David W ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; FEAR; MALE; MOLECULAR STRUCTURE; PYRIMIDINES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STARTLE REACTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030983280     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960861b     Document Type: Article

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