4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 7, 1999, Pages 1057-1062

  Cocuzza, Anthony J ^b   Hobbs, Frank W ^b   Arnold, Charles R ^b   Chidester, Dennis R ^b   Yarem, Jerry A ^b   Culp, Steven ^a   Fitzgerald, Lawrence ^a   Gilligan, Paul J ^b  

^a DUPONT COMPANY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 ANILINOPYRIMIDINE DERIVATIVE; AROMATIC COMPOUND; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; HORMONAL REGULATION; HORMONE BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CELL LINE; HUMANS; PROTEIN BINDING; PYRIMIDINES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0000797165     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00132-8     Document Type: Article

References (18)

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18. i < 50 nm, otherwise they are single determinations. Selected compounds were shown to be silent antagonists in that they completely inhibited CRH-stimulated adenylyl cyclase activity in membranes from rat cortex without any effect by themselves (data not shown).