Synthesis and structure-affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor1 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 5, 2001, Pages 1349-1355

  Kumagai, Toshihito ^a   Okubo, Taketoshi ^a   Kataoka Okubo, Hiromi ^a   Chaki, Shigeyuki ^a   Okuyama, Shigeru ^a   Nakazato, Atsuro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,2,3,6 TETRAHYDROPYRIDINO)PYRIMIDINE DERIVATIVE; 4 (5 PHENYL 1,2,3,6 TETRAHYDROPYRIDINO) 2 (N ETHYL 2 BROMO 2 ISOPROPYLANILINO) 6 METHYLPYRIMIDINE; 4 [5 (2 METHYLPHENYL) 1,2,3,6 TETRAHYDROPYRIDINO] 2 (N ETHYL 2 METHYLTHIO 4 ISOPROPYLANILINO) 6 METHLPYRIMIDINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; NONHUMAN; PROTON TRANSPORT; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; FRONTAL LOBE; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MYOCARDIUM; PROTEIN BINDING; PYRIDINES; PYRIMIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034999415     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00004-9     Document Type: Article

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