Non-peptide corticotropin-releasing hormone antagonists: Syntheses and structure activity relationships of 2-anilinopyrimidines and -triazines

Journal of Medicinal Chemistry

Volumn 42, Issue 5, 1999, Pages 805-818

  Arvanitis, Argyrios G ^a   Gilligan, Paul J ^a   Chorvat, Robert J ^a   Cheeseman, Robert S ^a   Christos, Thomas E ^a   Bakthavatchalam, Rajagopal ^a   Beck, James P ^a   Cocuzza, Anthony J ^a   Hobbs, Frank W ^a   Wilde, Richard G ^a   Arnold, Charles ^a   Chidester, Dennis ^a   Curry, Matthew ^a   He, Liqi ^a   Hollis, Andrea ^a   Klaczkiewicz, John ^a   Krenitsky, Paul J ^a,b   Rescinito, Joseph P ^a   Scholfield, Everett ^a   Culp, Steven ^a,c   De Souza, Errol B ^a,d   Fitzgerald, Lawrence ^a   Grigoriadis, Dimitri ^a,d   Tam, S William ^a,e   Wong, Y Nancy ^a,f   Huang, Shiew Mei ^a,g   Shen, Helen L ^a   more..

^a DUPONT COMPANY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Neurocrine Biosciences ^*  (United States)

^d NEUROCRINE BIOSCIENCES INC   (United States)

^e NitroMed Inc   (United States)

^f CEPHALON INC   (United States)

^g CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 N [2 BROMO 4 (1 METHYLETHYL)PHENYL] N ETHYL 4,6 DIMETHYL 2 PYRIMIDINAMINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOPHORE; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; FRONTAL LOBE; HUMANS; PYRIMIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 0033545675     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980222w     Document Type: Article

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