Structure-activity studies on 4-substituted-2-anilinopyrimidine corticotropin releasing factor (CRF) antagonists

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 11, 1999, Pages 2321-2328

  Gilligan, Paul J ^a   He, Liqi ^a   Culp, Steven ^a   Fitzgerald, Lawrence ^a   Tam, S William ^a   Wong, Y Nancy ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Antagonists; Corticotropin releasing factor; Receptor; Substituent effects

Indexed keywords

ANILINE DERIVATIVE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; PYRIMIDINE DERIVATIVE;

ANXIETY; ARTICLE; BINDING AFFINITY; DEPRESSION; DRUG ACTIVITY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG STRUCTURE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ADENYLATE CYCLASE; ANILINE COMPOUNDS; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; PYRIMIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033492136     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00182-0     Document Type: Article

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