Design, synthesis and structure-affinity relationships of 4- methylidenepiperidine and 4-aryl-1,2,3,6-tetrahydropyridine derivatives as corticotropin-releasing factor1 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 5, 2000, Pages 1183-1193

  Nakazato, Atsuro ^a   Kumagai, Toshihito ^a   Okubo, Taketoshi ^a   Tanaka, Hideo ^a   Chaki, Shigeyuki ^a   Okuyama, Shigeru ^a   Tomisawa, Kazuyuki ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 PIPERIDEINE DERIVATIVE; 4 METHYLIDENEPIPERIDINE; BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DEPRESSION; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; PIPERIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0034044942     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00045-6     Document Type: Article

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