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Volumn 24, Issue 10, 1999, Pages 1089-1098

Corticotropin-releasing factor1 receptor as a target for therapeutic intervention

Author keywords

[No Author keywords available]

Indexed keywords

2 [N (2 BROMO 4 ISOPROPYLPHENYL) N ETHYLAMINO] 4 [4 (3 FLUOROPHENYL) 1,2,3,6 TETRAHYDRO 1 PYRIDINYL] 6 METHYLPYRIMIDINE; 4 [4 (3 FLUOROPHENYL) 1,2,3,6 TETRAHYDRO 1 PYRIDINYL] 2 [N ETHYL N (4 ISOPROPYL 2 METHYLTHIOPHENYL)AMINO] 6 METHYLPYRIMIDINE; 5 CHLORO 4 [N (CYCLOPROPYLMETHYL) N PROPYLAMINO] 2 METHYL 6 (2,4,6 TRICHLOROANILINO)PYRIMIDINE; 8 (2,4 DICHLOROPHENYL) 4 [2 METHOXY 1 (METHOXYMETHYL)ETHYLAMINO] 2,7 DIMETHYLPYRAZOLO[1,5 A][1,3,5]TRIAZINE; ANTALARMIN; BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR; MESSENGER RNA; NBI 30545; NBI 31200; PD 171729; RECEPTOR SUBTYPE; SA 241; SA 627; SC 241; SJ 948; SP 904; UNCLASSIFIED DRUG; XQ 771;

EID: 0032750541     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.10.665576     Document Type: Review
Times cited : (11)

References (82)
  • 1
    • 0019782980 scopus 로고
    • Characterization of a 41 residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta endorphin
    • Vale, W., Spiess, J., Rivier, C. et al. Characterization of a 41 residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta endorphin. Science 1981, 213: 1394-7.
    • (1981) Science , vol.213 , pp. 1394-1397
    • Vale, W.1    Spiess, J.2    Rivier, C.3
  • 2
    • 0025241288 scopus 로고
    • Physiological and behavioral responses to corticotropin-releasing factor administration: Is CRF a mediator of anxiety of stress responses?
    • Dunn, A.J., Berridge, C.W. Physiological and behavioral responses to corticotropin-releasing factor administration: Is CRF a mediator of anxiety of stress responses? Brain Res Rev 1990, 15: 71-100.
    • (1990) Brain Res Rev , vol.15 , pp. 71-100
    • Dunn, A.J.1    Berridge, C.W.2
  • 3
    • 0026332080 scopus 로고
    • Physiology and pharmacology of corticotropin-releasing factor
    • Owens, M.J., Nemeroff, C.B. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 1991, 43: 425-73.
    • (1991) Pharmacol Rev , vol.43 , pp. 425-473
    • Owens, M.J.1    Nemeroff, C.B.2
  • 4
    • 0022454950 scopus 로고
    • Activating and anxiogenic effects of corticotropin-releasing factor are not inhibited by blockage of the pituitary-adrenal system with dexamethasone
    • Britton, K.T., Lee, G., Dana, R. et al. Activating and anxiogenic effects of corticotropin-releasing factor are not inhibited by blockage of the pituitary-adrenal system with dexamethasone. Life Sci 1986, 39: 1281-6.
    • (1986) Life Sci , vol.39 , pp. 1281-1286
    • Britton, K.T.1    Lee, G.2    Dana, R.3
  • 5
    • 0022553672 scopus 로고
    • Corticotropin-releasing factor (CRF) receptor antagonist blocks activating and anxiogenic actions of CRF in the rat
    • Britton, K.T., Lee, G., Vale, W. et al. Corticotropin-releasing factor (CRF) receptor antagonist blocks activating and anxiogenic actions of CRF in the rat. Brain Res 1986, 369: 303-6.
    • (1986) Brain Res , vol.369 , pp. 303-306
    • Britton, K.T.1    Lee, G.2    Vale, W.3
  • 6
    • 0030764217 scopus 로고
    • Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat
    • Buwalda, S., De Boer, S.F., Van Kalkeren, A.A. et al. Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat. Psychoneuroendocrinology 1977, 22: 297-309.
    • (1977) Psychoneuroendocrinology , vol.22 , pp. 297-309
    • Buwalda, S.1    De Boer, S.F.2    Van Kalkeren, A.A.3
  • 7
    • 0028907281 scopus 로고
    • Brain corticotropin-releasing factor mediates anxiety-like behaviour induced by cocaine withdrawal in rats
    • Sarnyai, Z., Biro, E., Gardi, J. et al. Brain corticotropin-releasing factor mediates anxiety-like behaviour induced by cocaine withdrawal in rats. Brain Res 1995, 675: 89-95.
    • (1995) Brain Res , vol.675 , pp. 89-95
    • Sarnyai, Z.1    Biro, E.2    Gardi, J.3
  • 8
    • 0028625387 scopus 로고
    • Corticotropin-releasing hormone (CRF) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats
    • Skutella, T., Montkowski, A., Stohr, T. et al. Corticotropin-releasing hormone (CRF) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats. Cell Mol Neurobiol 1994, 14: 579-88.
    • (1994) Cell Mol Neurobiol , vol.14 , pp. 579-588
    • Skutella, T.1    Montkowski, A.2    Stohr, T.3
  • 9
    • 0020665502 scopus 로고
    • Effect of centrally administered corticotropin-releasing factor (CRF) on multiple feeding paradigms
    • Levine, A.S., Rogers, B., Kneip, J. et al. Effect of centrally administered corticotropin-releasing factor (CRF) on multiple feeding paradigms. Neuropharmacology 1983, 22: 337-9.
    • (1983) Neuropharmacology , vol.22 , pp. 337-339
    • Levine, A.S.1    Rogers, B.2    Kneip, J.3
  • 10
    • 0020571142 scopus 로고
    • Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat
    • Sirinathsinghji, D.J.S., Rees, L.H., Rivier, J.H. et al. Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat. Nature 1983, 305: 232-5.
    • (1983) Nature , vol.305 , pp. 232-235
    • Sirinathsinghji, D.J.S.1    Rees, L.H.2    Rivier, J.H.3
  • 11
    • 0021080334 scopus 로고
    • Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats
    • Ehlers, C., Henriksen, S., Wang, M. et al. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res 1983, 278: 332-6.
    • (1983) Brain Res , vol.278 , pp. 332-336
    • Ehlers, C.1    Henriksen, S.2    Wang, M.3
  • 12
    • 0021714606 scopus 로고
    • Elevated concentrations of CSF corticotropin-releasing factor-like immunore-activity in depressed patients
    • Nemeroff, C.B., Widerlov, E., Bissette, G. et al. Elevated concentrations of CSF corticotropin-releasing factor-like immunore-activity in depressed patients. Science 1984, 226: 1342-4.
    • (1984) Science , vol.226 , pp. 1342-1344
    • Nemeroff, C.B.1    Widerlov, E.2    Bissette, G.3
  • 13
    • 0003037309 scopus 로고
    • CSF levels of corticotropin-releasing factor in chronic post-traumatic stress disorder
    • Darnell, A., Bremner, J.D., Licinio, J. et al. CSF levels of corticotropin-releasing factor in chronic post-traumatic stress disorder. Soc Neurosci Abst 1994, 20: 17.
    • (1994) Soc Neurosci Abst , vol.20 , pp. 17
    • Darnell, A.1    Bremner, J.D.2    Licinio, J.3
  • 14
    • 1842606918 scopus 로고
    • Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression
    • Holsboer, F., Von Bardeleben, U., Gerken, A. et al. Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. New Engl J Med 1984, 311:1127.
    • (1984) New Engl J Med , vol.311 , pp. 1127
    • Holsboer, F.1    Von Bardeleben, U.2    Gerken, A.3
  • 15
    • 0023726586 scopus 로고
    • Corticotropin-releasing hormone
    • Taylor, A.L., Fishman, L.M. Corticotropin-releasing hormone. New Engl J Med 1988, 319: 213-22.
    • (1988) New Engl J Med , vol.319 , pp. 213-222
    • Taylor, A.L.1    Fishman, L.M.2
  • 16
    • 0021241705 scopus 로고
    • Synthetic competitive antagonists of corticotropin-releasing factor: Effects on ACTH secretion in the rat
    • Rivier, J., Rivier, C., Vale, W. Synthetic competitive antagonists of corticotropin-releasing factor: Effects on ACTH secretion in the rat. Science 1984, 224: 889-91.
    • (1984) Science , vol.224 , pp. 889-891
    • Rivier, J.1    Rivier, C.2    Vale, W.3
  • 18
    • 0028800601 scopus 로고
    • Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain
    • Lovenberg, T.W, Liaw, C.W, Grigoriadis, D.E. et al. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci USA 1995, 92: 836-40.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 836-840
    • Lovenberg, T.W.1    Liaw, C.W.2    Grigoriadis, D.E.3
  • 19
    • 0029833116 scopus 로고    scopus 로고
    • Regulation of corticotropin-releasing factor type 1 (CRF) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF
    • Mansi, J.A., Rivest, S., Drolet, G. Regulation of corticotropin-releasing factor type 1 (CRF) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF. Endocrinology 1996, 137: 4619-26.
    • (1996) Endocrinology , vol.137 , pp. 4619-4626
    • Mansi, J.A.1    Rivest, S.2    Drolet, G.3
  • 21
    • 0028980154 scopus 로고
    • 2β receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues
    • 2β receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology 1995, 136: 4139-42.
    • (1995) Endocrinology , vol.136 , pp. 4139-4142
    • Lovenberg, T.W.1    Chalmers, D.T.2    Liu, C.3
  • 22
    • 0028567196 scopus 로고
    • Stress-specific regulation of corticotropin-releasing hormone receptor expression in the paraventricular and supraoptic nuclei of the hypothalamus in the rat
    • Luo, Y., Kiss, A., Makara, G. et al. Stress-specific regulation of corticotropin-releasing hormone receptor expression in the paraventricular and supraoptic nuclei of the hypothalamus in the rat. J Neuroendocrinol 1994, 6: 689-96.
    • (1994) J Neuroendocrinol , vol.6 , pp. 689-696
    • Luo, Y.1    Kiss, A.2    Makara, G.3
  • 23
    • 0028953834 scopus 로고
    • Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus
    • Rivest, S., Laflamme, N., Nappi, R.E. Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus. J Neurosci 1995, 15: 2680-95.
    • (1995) J Neurosci , vol.15 , pp. 2680-2695
    • Rivest, S.1    Laflamme, N.2    Nappi, R.E.3
  • 24
    • 0029086132 scopus 로고
    • Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress
    • Makino, S., Schulkin, J., Smith, M.A. et al. Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress. Endocrinology 1995, 136: 4517-25.
    • (1995) Endocrinology , vol.136 , pp. 4517-4525
    • Makino, S.1    Schulkin, J.2    Smith, M.A.3
  • 25
    • 0030745647 scopus 로고    scopus 로고
    • Differential regulation of type-1 and type-2α corticotropin-releasing hormone receptor mRNA in the hypothalamic paraventricular nucleus of the rat
    • Makino, S., Takemura, T., Asaba, K. et al. Differential regulation of type-1 and type-2α corticotropin-releasing hormone receptor mRNA in the hypothalamic paraventricular nucleus of the rat. Mol Brain Res 1997, 47: 170-6.
    • (1997) Mol Brain Res , vol.47 , pp. 170-176
    • Makino, S.1    Takemura, T.2    Asaba, K.3
  • 27
    • 0026688974 scopus 로고
    • Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action
    • Heinrichs, S.C., Merlo-Pich, E., Miczek, K.A. et al. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Res 1992, 581: 190-7.
    • (1992) Brain Res , vol.581 , pp. 190-197
    • Heinrichs, S.C.1    Merlo-Pich, E.2    Miczek, K.A.3
  • 28
    • 0027536067 scopus 로고
    • The central role of corticotropin-releasing factor (CRF1-41) in psychological stress in rats
    • Morimoto, A., Nakamori, T., Moromoto, K. et al. The central role of corticotropin-releasing factor (CRF1-41) in psychological stress in rats. J Physiol 1993, 460: 221-9.
    • (1993) J Physiol , vol.460 , pp. 221-229
    • Morimoto, A.1    Nakamori, T.2    Moromoto, K.3
  • 29
    • 0028364434 scopus 로고
    • Characterization of a novel and potent corticotropin-releasing factor antagonist in rats
    • Menzaghi, F., Howard, R.L., Heinrichs, S.C. et al. Characterization of a novel and potent corticotropin-releasing factor antagonist in rats. J Pharmacol Exp Ther 1994, 269: 564-72.
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 564-572
    • Menzaghi, F.1    Howard, R.L.2    Heinrichs, S.C.3
  • 30
    • 0026680287 scopus 로고
    • Alanine series of ovine corticotropin-releasing factor (oCRF): A structure-activity relationship study
    • Kornreich, W.D., Galyean, R., Hernández, J-F. et al. Alanine series of ovine corticotropin-releasing factor (oCRF): A structure-activity relationship study. J Med Chem 1992, 35: 1870-6.
    • (1992) J Med Chem , vol.35 , pp. 1870-1876
    • Kornreich, W.D.1    Galyean, R.2    Hernández, J.-F.3
  • 31
    • 0027484160 scopus 로고
    • Single point D-substituted corticotropin-releasing factor analogues: Effects on potency and physicochemical characteristics
    • Rivier, J., Rivier, C., Galyean, R. et al. Single point D-substituted corticotropin-releasing factor analogues: Effects on potency and physicochemical characteristics. J Med Chem 1993, 36: 2851-9.
    • (1993) J Med Chem , vol.36 , pp. 2851-2859
    • Rivier, J.1    Rivier, C.2    Galyean, R.3
  • 32
    • 0027367392 scopus 로고
    • Synthesis and relative potencies of new constrained CRF antagonists
    • Hernández, J-F., Korneich, W., Rivier, C. et al. Synthesis and relative potencies of new constrained CRF antagonists. J Med Chem 1993, 36: 2860-7.
    • (1993) J Med Chem , vol.36 , pp. 2860-2867
    • Hernández, J.-F.1    Korneich, W.2    Rivier, C.3
  • 33
    • 0028238388 scopus 로고
    • Conformationally restricted competitive antagonists of human/rat corticotropin-releasing factor
    • Miranda, A., Koerber, S.C., Gulyas, J. et al. Conformationally restricted competitive antagonists of human/rat corticotropin-releasing factor. J Med Chem 1994, 37: 1450-9.
    • (1994) J Med Chem , vol.37 , pp. 1450-1459
    • Miranda, A.1    Koerber, S.C.2    Gulyas, J.3
  • 34
    • 0028800423 scopus 로고
    • Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor (CRF)
    • Gulyas, J., Rivier, C., Perrin, M. et al. Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor (CRF). Proc Natl Acad Sci USA 1995, 92: 10575-9.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10575-10579
    • Gulyas, J.1    Rivier, C.2    Perrin, M.3
  • 35
    • 0029786101 scopus 로고    scopus 로고
    • A single-point slight alteration set as a tool for structure-activity relationship studies of ovine corticotropin-releasing factor
    • Beyermann, M., Fechner, K., Furkert, J. et al. A single-point slight alteration set as a tool for structure-activity relationship studies of ovine corticotropin-releasing factor. J Med Chem 1996, 39: 3324-30.
    • (1996) J Med Chem , vol.39 , pp. 3324-3330
    • Beyermann, M.1    Fechner, K.2    Furkert, J.3
  • 36
    • 0030725748 scopus 로고    scopus 로고
    • Constrained corticotropin-releasing factor antagonists with i-(i + 3) Glu-Lys bridges
    • Miranda, A., Lahrichi, S.L., Gulyas, J. et al. Constrained corticotropin-releasing factor antagonists with i-(i + 3) Glu-Lys bridges. J Med Chem 1997, 40: 3651-8.
    • (1997) J Med Chem , vol.40 , pp. 3651-3658
    • Miranda, A.1    Lahrichi, S.L.2    Gulyas, J.3
  • 37
    • 0032474856 scopus 로고    scopus 로고
    • Minimal-size, constrained corticotropin-releasing factor agonists with i-(i + 3) Glu-Lys and Lys-Glu bridges
    • River, J., Lahrichi, S.L., Gulyas, J. et al. Minimal-size, constrained corticotropin-releasing factor agonists with i-(i + 3) Glu-Lys and Lys-Glu bridges. J Med Chem 1998, 41: 2614-20.
    • (1998) J Med Chem , vol.41 , pp. 2614-2620
    • River, J.1    Lahrichi, S.L.2    Gulyas, J.3
  • 38
    • 0032480914 scopus 로고    scopus 로고
    • Constrained corticotropin-releasing factor (CRF) agonists and antagonists with i-(i + 3) Glu-Xaa-DXbb-Lys bridges
    • Koerber, S.C., Gulyas J., Lahrichi, S.L. et al. Constrained corticotropin-releasing factor (CRF) agonists and antagonists with i-(i + 3) Glu-Xaa-DXbb-Lys bridges. J Med Chem 1998, 41: 5002-11.
    • (1998) J Med Chem , vol.41 , pp. 5002-5011
    • Koerber, S.C.1    Gulyas, J.2    Lahrichi, S.L.3
  • 41
    • 0029862077 scopus 로고    scopus 로고
    • Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: Application to the synthesis and optimization of corticotropin-releasing factor 1 receptor antagonists
    • Whitten, J.P., Xie, Y.F., Erickson, P.E. et al. Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: Application to the synthesis and optimization of corticotropin-releasing factor 1 receptor antagonists. J Med Chem 1996, 39: 4354-7.
    • (1996) J Med Chem , vol.39 , pp. 4354-4357
    • Whitten, J.P.1    Xie, Y.F.2    Erickson, P.E.3
  • 42
    • 0029915494 scopus 로고    scopus 로고
    • Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor 1 receptor antagonists
    • Chen, C., Dagnino, R., De Souza, E.B. et al. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor 1 receptor antagonists. J Med Chem 1996, 39: 4358-60.
    • (1996) J Med Chem , vol.39 , pp. 4358-4360
    • Chen, C.1    Dagnino, R.2    De Souza, E.B.3
  • 43
    • 0344409248 scopus 로고    scopus 로고
    • 1 receptors in restraint-, CRF-, and urocortin-induced anxiety-like behaviors
    • Nov 7-12, Los Angeles Abst 470.15
    • 1 receptors in restraint-, CRF-, and urocortin-induced anxiety-like behaviors. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 470.15.
    • (1998) 28th Annu Meet Soc Neurosci
    • Smagin, G.N.1    Ryan, D.H.2    De Souza, E.B.3
  • 44
    • 0030609107 scopus 로고    scopus 로고
    • 1 receptor mediates the excitatory action of corticotropin releasing factor (CRF) in the developing rat brain: In vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
    • 1 receptor mediates the excitatory action of corticotropin releasing factor (CRF) in the developing rat brain: In vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res 1997, 770: 89-95.
    • (1997) Brain Res , vol.770 , pp. 89-95
    • Baram, T.Z.1    Chalmers, D.T.2    Chen, C.3
  • 48
    • 0032903413 scopus 로고    scopus 로고
    • Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001
    • Okuyama, S., Chaki, S., Kawashima, N. et al. Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001. J Pharmacol Exp Ther 1999, 289: 926-35.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 926-935
    • Okuyama, S.1    Chaki, S.2    Kawashima, N.3
  • 49
    • 0032475482 scopus 로고    scopus 로고
    • Non-peptidic corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: Evidence that an increase in arousal induced by stress is mediated through CRH receptor type 1
    • Aral, K., Ohata, H., Shibasaki, T. Non-peptidic corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: Evidence that an increase in arousal induced by stress is mediated through CRH receptor type 1. Neurosci Lett 1998, 255: 103-6.
    • (1998) Neurosci Lett , vol.255 , pp. 103-106
    • Aral, K.1    Ohata, H.2    Shibasaki, T.3
  • 50
    • 0033608746 scopus 로고    scopus 로고
    • Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats
    • Hotta, M., Shibasaki, T., Arai, K. et al. Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats. Brain Res 1999, 823: 221-5.
    • (1999) Brain Res , vol.823 , pp. 221-225
    • Hotta, M.1    Shibasaki, T.2    Arai, K.3
  • 51
    • 0033545675 scopus 로고    scopus 로고
    • Non-peptide corticotropin-releasing hormone antagonists: Syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines
    • Arvanitis, A.G., Gilligan, P.J., Chorvat, R.J. et al. Non-peptide corticotropin-releasing hormone antagonists: Syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines. J Med Chem 1999, 42: 805-18.
    • (1999) J Med Chem , vol.42 , pp. 805-818
    • Arvanitis, A.G.1    Gilligan, P.J.2    Chorvat, R.J.3
  • 52
    • 0030983280 scopus 로고    scopus 로고
    • Synthesis and oral efficacy of 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: A centrally active corticotropin-releasing factor 1 receptor antagonist
    • Chen, Y.L., Mansbach, R.S., Winter, S.M. et al. Synthesis and oral efficacy of 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: A centrally active corticotropin-releasing factor 1 receptor antagonist. J Med Chem 1997, 40: 1749-54.
    • (1997) J Med Chem , vol.40 , pp. 1749-1754
    • Mansbach, R.S.1    Winter, S.M.2
  • 53
    • 0345272237 scopus 로고    scopus 로고
    • 1 receptor antagonist in the separation-induced vocalization model of anxiety in rat pups
    • Nov 7-12, Los Angeles Abst 82.5
    • 1 receptor antagonist in the separation-induced vocalization model of anxiety in rat pups. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 82.5.
    • (1998) 28th Annu Meet Soc Neurosci
    • Coverdale, S.1    McCloskey, T.C.2    Cassella, J.V.3
  • 54
    • 0344409245 scopus 로고    scopus 로고
    • 1 receptor antagonist on shock-elicited startle, a novel model for assessing antistress activity of compounds
    • Nov 7-12, Los Angeles Abst 82.3
    • 1 receptor antagonist on shock-elicited startle, a novel model for assessing antistress activity of compounds. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 82.3.
    • (1998) 28th Annu Meet Soc Neurosci
    • Cain, C.K.1    Hoffman, D.C.2    Cassella, J.V.3
  • 55
    • 0345272235 scopus 로고    scopus 로고
    • 1 receptor antagonist in the Porsolt forced swim task, a model of depression
    • Nov 7-12, Los Angeles Abst 82.4
    • 1 receptor antagonist in the Porsolt forced swim task, a model of depression. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 82.4.
    • (1998) 28th Annu Meet Soc Neurosci
    • Ward, S.J.1    Cassella, J.V.2    Kehne, J.H.3
  • 56
    • 0344409244 scopus 로고    scopus 로고
    • Regulation of corticotropin releasing factor receptor-1 (CRF-R1) and BDNF by morphine withdrawal
    • Nov 7-12, Los Angeles Abst 582.13
    • Lee, Y., Terwilliger, R.Z., Duman, R.S. Regulation of corticotropin releasing factor receptor-1 (CRF-R1) and BDNF by morphine withdrawal. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 582.13.
    • (1998) 28th Annu Meet Soc Neurosci
    • Lee, Y.1    Terwilliger, R.Z.2    Duman, R.S.3
  • 57
    • 0344840869 scopus 로고    scopus 로고
    • Chronic treatment with the CRF receptor antagonist CP-154,526 decreases defensive withdrawal but does not alter neuroendocrine responses to an acute stressor
    • Nov 7-12, Los Angeles Abst 583.3
    • Arborelius, L., Thrivikraman, K.V., Plotsky, P.M. Chronic treatment with the CRF receptor antagonist CP-154,526 decreases defensive withdrawal but does not alter neuroendocrine responses to an acute stressor. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 583.3.
    • (1998) 28th Annu Meet Soc Neurosci
    • Arborelius, L.1    Thrivikraman, K.V.2    Plotsky, P.M.3
  • 58
    • 0344409237 scopus 로고    scopus 로고
    • 1 antagonist, CP-154,526, in the Vogel and ultrasonic vocalization (USV) tests
    • Nov 7-12, Los Angeles Abst 583.5
    • 1 antagonist, CP-154,526, in the Vogel and ultrasonic vocalization (USV) tests. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 583.5.
    • (1998) 28th Annu Meet Soc Neurosci
    • Brocco, M.1    Dekeyne, A.2    Dorey, G.3
  • 59
    • 0013522651 scopus 로고    scopus 로고
    • CP-154,526: A potent and selective nonpeptide antagonist of corticotropin-releasing factor receptors
    • Schulz, W.D., Mansbach, R.S., Sprouse, J. et al. CP-154,526: A potent and selective nonpeptide antagonist of corticotropin-releasing factor receptors. Proc Natl Acad Sci USA 1996, 93: 10477-82.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10477-10482
    • Schulz, W.D.1    Mansbach, R.S.2    Sprouse, J.3
  • 60
    • 0030575520 scopus 로고    scopus 로고
    • A nonpeptide corticotropin-releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity
    • Lundkvist, J., Chai, Z., Teheranian, R. et al. A nonpeptide corticotropin-releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur J Pharmacol 1996, 309: 195-200.
    • (1996) Eur J Pharmacol , vol.309 , pp. 195-200
    • Lundkvist, J.1    Chai, Z.2    Teheranian, R.3
  • 62
    • 0031960095 scopus 로고    scopus 로고
    • 1 receptor attenuates stress-induced relapse to drug seeking in cocaine-and heroin-trained rats
    • 1 receptor attenuates stress-induced relapse to drug seeking in cocaine-and heroin-trained rats. Psychopharmacology 1998, 137: 184-90.
    • (1998) Psychopharmacology , vol.137 , pp. 184-190
    • Shaham, Y.1    Erb, S.2    Leung, S.3
  • 63
    • 0030445812 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of antalarmine, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammation
    • Webster, E.L., Lewis, D.B., Torpy, D.J. et al. In vivo and in vitro characterization of antalarmine, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 1996, 137: 5747-50.
    • (1996) Endocrinology , vol.137 , pp. 5747-5750
    • Webster, E.L.1    Lewis, D.B.2    Torpy, D.J.3
  • 64
    • 0033545667 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone receptor antagonists: Framework design and synthesis guided by ligand conformational studies
    • Hodge, C.N., Aldrich, P.E., Wasserman Z.R. et al. Corticotropin-releasing hormone receptor antagonists: Framework design and synthesis guided by ligand conformational studies. J Med Chem 1999, 42: 819-32.
    • (1999) J Med Chem , vol.42 , pp. 819-832
    • Hodge, C.N.1    Aldrich, P.E.2    Wasserman, Z.R.3
  • 66
    • 0033545628 scopus 로고    scopus 로고
    • Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines
    • Chorvat, R.J., Bakthavatchalam, R., Beck, J.P. et al. Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem 1999, 42: 833-48.
    • (1999) J Med Chem , vol.42 , pp. 833-848
    • Chorvat, R.J.1    Bakthavatchalam, R.2    Beck, J.P.3
  • 67
    • 0033526094 scopus 로고    scopus 로고
    • Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists
    • Beck, J.P., Arvanitis, A.G., Curry, M.A. et al. Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett 1999, 9: 967-72.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 967-972
    • Beck, J.P.1    Arvanitis, A.G.2    Curry, M.A.3
  • 68
    • 0344409238 scopus 로고    scopus 로고
    • Thiazolo[4,5-d]pyrimidine thiones and -ones as potent corticotropin-releasing hormone (CRH-R1) receptor antagonists
    • Aug 23-27, Boston Abst MEDI 136
    • Curry, M.A., Beck, J.P., Folmer, B.K. et al. Thiazolo[4,5-d]pyrimidine thiones and -ones as potent corticotropin-releasing hormone (CRH-R1) receptor antagonists. 216th ACS Natl Meet (Aug 23-27, Boston) 1998, Abst MEDI 136.
    • (1998) 216th ACS Natl Meet
    • Curry, M.A.1    Beck, J.P.2    Folmer, B.K.3
  • 69
    • 0032544170 scopus 로고    scopus 로고
    • Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists
    • Wustrow, D.J., Capiris, T., Rubin, R. et al. Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists. Bioorg Med Chem Lett 1998, 8: 2067-70.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 2067-2070
    • Wustrow, D.J.1    Capiris, T.2    Rubin, R.3
  • 70
    • 0344409239 scopus 로고    scopus 로고
    • The non-peptide CRF-R1 antagonist, PD171729, inhibits corticotropin-releasing factor (CRF)-induced norepinephrine release in the cortex of rats
    • Nov 7-12, Los Angeles Abst 583.2
    • Davis, M.D., Cooke, L.W. The non-peptide CRF-R1 antagonist, PD171729, inhibits corticotropin-releasing factor (CRF)-induced norepinephrine release in the cortex of rats. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 583.2.
    • (1998) 28th Annu Meet Soc Neurosci
    • Davis, M.D.1    Cooke, L.W.2
  • 71
    • 0345703786 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of PD171729, a nonpeptide corticotropin-releasing factor (CRF) receptor antagonist
    • Nov 7-12, Los Angeles Abst 234.10
    • Pugsley, T., Akunne, H., Zoski, K. et al. In vitro and in vivo characterization of PD171729, a nonpeptide corticotropin-releasing factor (CRF) receptor antagonist. 28th Annu Meet Soc Neurosci (Nov 7-12, Los Angeles) 1998, Abst 234.10.
    • (1998) 28th Annu Meet Soc Neurosci
    • Pugsley, T.1    Akunne, H.2    Zoski, K.3
  • 72
    • 0038405783 scopus 로고    scopus 로고
    • Design and synthesis of NBI-30545 and analogues as potent CPF receptor antagonists
    • March 21-25, Anaheim Abst MEDI 002
    • Wilcoxen, K., Chen, C., Huang, C. et al. Design and synthesis of NBI-30545 and analogues as potent CPF receptor antagonists. 217th ACS Natl Meet (March 21-25, Anaheim) 1999, Abst MEDI 002.
    • (1999) 217th ACS Natl Meet
    • Wilcoxen, K.1    Chen, C.2    Huang, C.3
  • 73
    • 0342723213 scopus 로고    scopus 로고
    • Pyrazolo-[1,5-a]-pyrimidine CRF antagonists: Synthesis and structure activity relationships
    • Aug 23-27, Boston Abst MEDI 135
    • Gilligan, P.J., Baldauf, C., Cocuzza, A. et al. Pyrazolo-[1,5-a]-pyrimidine CRF antagonists: Synthesis and structure activity relationships. 216th ACS Natl Meet (Aug 23-27, Boston) 1998, Abst MEDI 135.
    • (1998) 216th ACS Natl Meet
    • Gilligan, P.J.1    Baldauf, C.2    Cocuzza, A.3
  • 74
    • 0342266933 scopus 로고    scopus 로고
    • 1 receptor antagonists: Design, synthesis and structure activity relationships
    • March 21-25, Anaheim Abst MEDI 107
    • 1 receptor antagonists: Design, synthesis and structure activity relationships. 217th ACS Natl Meet (March 21-25, Anaheim) 1999, Abst MEDI 107.
    • (1999) 217th ACS Natl Meet
    • He, L.1    Gilligan, P.J.2    Fitzgerald, L.3
  • 75
    • 0344409234 scopus 로고    scopus 로고
    • DMP696: A potent, orally bioavailable pyrazolo-[1,5-a]-s-triazine corticotropin-releasing factor (CRF) antagonist
    • March 21-25, Anaheim Abst MEDI 004
    • Gilligan, P.J., He, L., Zaczek, R. et al. DMP696: A potent, orally bioavailable pyrazolo-[1,5-a]-s-triazine corticotropin-releasing factor (CRF) antagonist. 217th ACS Natl Meet (March 21-25, Anaheim) 1999, Abst MEDI 004.
    • (1999) 217th ACS Natl Meet
    • Gilligan, P.J.1    He, L.2    Zaczek, R.3
  • 77
    • 0345272227 scopus 로고    scopus 로고
    • Imidazo[4,5-c]pyrazoles: A novel heterocyclic series of corticotropin-releasing hormone (CRF-R1) antagonists
    • March 21-25, Anaheim Abst MEDI 001
    • Beck, J.R., Tivitmahaisoon, R., Folmer, B.K. et al. Imidazo[4,5-c]pyrazoles: A novel heterocyclic series of corticotropin-releasing hormone (CRF-R1) antagonists. 217th ACS Natl Meet (March 21-25, Anaheim) 1999, Abst MEDI 001.
    • (1999) 217th ACS Natl Meet
    • Beck, J.R.1    Tivitmahaisoon, R.2    Folmer, B.K.3
  • 78
    • 0343434045 scopus 로고    scopus 로고
    • Imidazo[4,5-c]pyrazoles as corticotropin-releasing hormone (CRF-R1) receptor antagonists: Detailed pyrazole SAR and synthesis
    • March 21-25, Anaheim Abst MEDI 106
    • Beck, J.P., Folmer, B.K. Curry, M.A. et al. Imidazo[4,5-c]pyrazoles as corticotropin-releasing hormone (CRF-R1) receptor antagonists: Detailed pyrazole SAR and synthesis. 217th ACS Natl Meet (March 21-25, Anaheim) 1999, Abst MEDI 106.
    • (1999) 217th ACS Natl Meet
    • Beck, J.P.1    Folmer, B.K.2    Curry, M.A.3
  • 79
    • 0344409230 scopus 로고    scopus 로고
    • N-Aryl aminotriazolopyrimidines as corticotropin-releasing hormone (CRH-R1) antagonists
    • March 29-April 2, Dallas Abst MEDI 140
    • Beck, J.R., Bakthavatchalam, R., Curry, M.A. et al. N-Aryl aminotriazolopyrimidines as corticotropin-releasing hormone (CRH-R1) antagonists. 215th ACS Natl Meet (March 29-April 2, Dallas) 1998, Abst MEDI 140.
    • (1998) 215th ACS Natl Meet
    • Beck, J.R.1    Bakthavatchalam, R.2    Curry, M.A.3
  • 80
    • 0344409231 scopus 로고    scopus 로고
    • Aryloxytriazolopyridines and -pyrimidines: Potent corticotropin-releasing hormone receptor (CRH1) antagonists. Synthesis and SAR
    • March 29-April 2, Dallas Abst MEDI 142
    • Rajagopalan, R., Junnier, M.L., Chorvat, R.J. et al. Aryloxytriazolopyridines and -pyrimidines: Potent corticotropin-releasing hormone receptor (CRH1) antagonists. Synthesis and SAR. 215th ACS Natl Meet (March 29-April 2, Dallas) 1998, Abst MEDI 142.
    • (1998) 215th ACS Natl Meet
    • Rajagopalan, R.1    Junnier, M.L.2    Chorvat, R.J.3
  • 81
    • 0344409228 scopus 로고    scopus 로고
    • N-Aryl aminotriazolopyrimidines and -pyridines: Synthesis and evaluation as selective corticotropin-releasing hormone (CRH1) receptor antagonists
    • March 29-April 2, Dallas Abst MEDI 143
    • Bakthavatchalam, R., Arnold, C.R., Arvanitis, A.G. N-Aryl aminotriazolopyrimidines and -pyridines: Synthesis and evaluation as selective corticotropin-releasing hormone (CRH1) receptor antagonists. 215th ACS Natl Meet (March 29-April 2, Dallas) 1998, Abst MEDI 143.
    • (1998) 215th ACS Natl Meet
    • Bakthavatchalam, R.1    Arnold, C.R.2    Arvanitis, A.G.3
  • 82
    • 0342998494 scopus 로고    scopus 로고
    • Aryland anilino-triazolopyridines as corticotropin-releasing factor (CRF) receptor antagonists
    • March 29-April 2, Dallas Abst MEDI 144
    • Arvanitis, A.G., Bakthavatchalam, R., Beck, J.P. et al. Aryland anilino-triazolopyridines as corticotropin-releasing factor (CRF) receptor antagonists. 215th ACS Natl Meet (March 29-April 2, Dallas) 1998, Abst MEDI 144.
    • (1998) 215th ACS Natl Meet
    • Arvanitis, A.G.1    Bakthavatchalam, R.2    Beck, J.P.3


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