Functional analysis of drug resistance in Plasmodium falciparum in the post-genomic era

International Journal for Parasitology

Volumn 31, Issue 9, 2001, Pages 871-878

  Cowman, Alan F ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Bioinformatics; Chloroquine; Drug resistance; Genetics; Malaria; Mefloquine; Microarray; Plasmodium falciparum; Quinine; Transfection

Indexed keywords

CHLOROQUINE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; PROGUANIL; PYRIMETHAMINE; SULFADOXINE; SULFONAMIDE; SULFONE; VERAPAMIL;

ADJUVANT CHEMOTHERAPY; ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; CONFERENCE PAPER; GENE MAPPING; GENE SEQUENCE; GENETIC LINKAGE; GENETIC TRANSFECTION; GENOME; MALARIA; MARKER GENE; NONHUMAN; PLASMODIUM FALCIPARUM; TECHNOLOGY;

ANIMALS; ANTIMALARIALS; DRUG RESISTANCE; GENETIC MARKERS; GENOME, PROTOZOAN; HUMANS; MALARIA, FALCIPARUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASMODIUM FALCIPARUM; TRANSFECTION;

CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034983065     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(01)00201-6     Document Type: Conference Paper

References (72)

1. Rates and risk factors for mortality during the first two years of life in rural Malawi
2. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum
3. Access to hematin: The basis of chloroquine resistance
4. Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum
5. + antiporter, chloroquine uptake and drug resistance: Inconsistencies in a newly proposed model
6. Sequence variation in the hydroxymethyldihydropterin pyrophosphokinase: Dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine
7. Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion
8. Kinetic and molecular properties of the dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant clones of the human malaria parasite Plasmodium falciparum
9. Synergistic antimalarial activity of pyrimethamine and sulfadoxine against Plasmodium falciparum in vitro
10. Chromosomes of Plasmodium falciparum
11. Chromosome size polymorphisms in Plasmodium falciparum can involve deletions and are frequent in natural parasite populations
12. Homologous recombination within subtelomeric repeat sequences generates chromosome size polymorphisms in P. falciparum
13. The P-glycoprotein homologues of Plasmodium falciparum: Are they involved in chloroquine resistance?
14. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
15. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole
16. Stable transgene expression in Plasmodium falciparum
17. Exploring the metabolic and gentic control of gene expression on a genomic scale
18. The mechanism of pyrimethamine resistance in Plasmodium falciparum
19. Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein
20. Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine
21. The biochemistry of P-glycoprotein-mediated multidrug resistance
22. Microsatellite markers and genetic mapping in Plasmodium falciparum
23. Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum
24. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
25. P. falciparum in Owl monkeys: Drug resistance and chloroquine binding capacity
26. Amplification of the multidrug resistance gene in some chloroquine- resistant isolates of P. falciparum
27. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
28. Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum
29. Sensitivity status of Plasmodium falciparum to chloroquine, amodiaquine, quinine, mefloquine and sulfadoxine/pyrimethamine in a tribal population of District Sundargarh, Orissa
30. Size variation in chromosomes from independent cultured isolates of Plasmodium falciparum
31. Repetitive proteins and genes of malaria
32. Antimalarial agents: Mechanism of chloroquine resistance
33. Chloroquine and acid vesicle function
34. Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum
35. Mechanism of pyrimethamine resistance in recent isolates of Plasmodium falciparum
36. Folic acid and biotin synthesis by sulfonamide-sensitive and sulfonamide-resistant strains of Escherichia coli
37. Characterisation of a repetitive DNA sequence from the malaria parasite, Plasmodium falciparum
38. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
39. Large deletions result from breakage and healing of Plasmodium falciparum chromosomes
40. The karyotype of Plasmodium falciparum determined by ultrastructural serial sectioning and 3D reconstruction
41. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand
42. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
43. Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance
44. Linking the genome and proteome by mass spectrometry: Large scale identification of yeast proteins from two dimensional gels
45. Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum
46. Malaria pigment
47. Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites
48. Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine
49. Plasmodium falciparum: Assignment of microsatellite markers to chromosomes by PFG-PCR
50. Complex polymorphisms in an ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
51. A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum
52. Haemozoin: Identification and quantification
53. Human malaria parasites in continuous culture
54. Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum
55. Mutations of dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum
56. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria
57. The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine
58. Structure and polymorphism of human telomere-associated DNA
59. Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine
60. Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr1 gene
61. Characterization of the yeast transcriptome
62. Chloroquine uptake by Plasmodium falciparum-infected human erythrocytes during in vitro culture and its relationship to chloroquine resistance
63. Altered dihydrofolate reductase in pyrimethamine-resistant Plasmodium falciparum
64. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization
65. Utilization of exogenous folate in the human malaria parasite Plasmodium falciparum and its critical role in antifolate drug synergy
66. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
67. The relation of p-aminobenzoic acid to the mechanism of the action of sulphanilamide
68. Transfection of Plasmodium falciparum within human red blood cells
69. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine
70. Susceptibility of human malaria parasites to chloroquine is pH dependent
71. Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum