Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease

Nature Genetics

Volumn 13, Issue 4, 1996, Pages 429-434

  Rubattu, Speranza ^a,b,c   Volpe, Massimo ^b,c,d   Kreutz, Reinhold ^a   Ganten, Ursula ^e   Ganten, Detlev ^e   Lindpaintner, Klaus ^a,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c IRCCS NEUROMED   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 1; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME MAP; GENOTYPE; MEAN ARTERIAL PRESSURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RAT; SEGREGATION ANALYSIS; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE;

ANIMALS; BLOOD PRESSURE; CEREBROVASCULAR DISORDERS; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; HUMANS; LINKAGE (GENETICS); PHENOTYPE; RATS; RATS, INBRED SHR;

ANIMALIA;

EID: 0030056248     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0896-429     Document Type: Article

References (39)

1. Kannel, W.B., Wolf, P.A., Verter, J. & McNamara, M.J. Epidemiological assessment of the role of blood pressure on stroke: the Framingham study. JAMA 214, 301-310 (1970).
2. Veterans Administration Cooperative Study Group on Antihypertensive Agents, Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA 213, 1143-1152 (1970).
3. Ostfeld, A.M., Shekelle, R.B., Klawans, H. & Tufo, H.M. Epidemiology of stroke in an elderly welfare population. Am. J. Public Health 64, 450-458 (1974).
4. Iso, H., Jacobs, D.R., Jr., Wentworth, D., Neaton, J.D. & Cohen, J.D. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial [see comments]. N. Engl. J. Med. 320, 904-910 (1989).
5. Kagan, A., Popper, J.S. & Rhoads, G.G. Factors related to stroke incidence in Hawaii Japanese men. The Honolulu Heart Study. Stroke 11, 14-21 (1980).
6. Gifford, A.J. An epidemiological study of cerebrovascular disease. Am. J. Public Health 56, 452-461 (1966).
7. Welin, L., Svardsudd, K., Wilhelmsen, L., Larsson, B. & Tibblin, G. Analysis of risk factors for stroke in a cohort of men born in 1913. N. Engl. J. Med. 317, 521-526 (1987).
8. Diaz, J.F., Hachinski, V.C., Pederson, L.L. & Donald, A. Aggregation of multiple risk factors for stroke in siblings of patients with brain infarction and transient ischemic attacks. Stroke 17, 1239-1242 (1986).
9. Marshall, J. Familial incidence of cerebrovascular disease. J. Med. Genet. 8, 84-89 (1971).
10. de Faire, U., Friberg, L. & Lundman, T. Concordance for mortality with special reference to ischemic heart disease and cerebrovascular disease: A study on the Swedish Twin Registry. Prev. Med. 4, 509-517 (1975).
11. Brass, L.M., Isaacson, J.L., Merikangas, K.R. & Robinette, C.D. A study of twins and stroke. Stroke 23, 221-223 (1992).
12. Palsdottir, A. et al. Mutation in cystatin C gene causes hereditary brain haemorrhage. Lancet 2, 603-604 (1988).
13. Boers, G.H. et al. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N. Engl. J. Med. 313, 709-715 (1985).
14. Levy, E. et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemormage, Dutch type. Science 248, 1124-1126 (1990).
15. Tournier-Lasserve, E. et al. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukencephalopathy maps to chromosome 19q12. Nature Genet. 3, 256-259 (1993).
16. Kannel, W.B. and Sorlie, P. Hypertension in Framingham. In Epidemiology and control of hypertension. (ed. Paul, O.) 553-592 (Stratton, New York, 1975).
17. Okamoto, K., Yamori, Y. & Nagaoka, A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ. Res. 33/34, I-143-I-153 (1974).
18. Slivka, A. Effect of antihypertensive therapy on focal stroke in spontaneously hypertensive rats. Stroke 22, 884-888 (1991).
19. Yamori, Y., Horie, R., Tanase, H., Fujiwara, K., Nara, Y. & Lovenberg, W. Possible role of nutritional factors in the incidence of cerebral lesions in stroke-prone spontaneously hypertensive rats. Hypertension 6, 49-53 (1984).
20. Nagaoka A., Iwatsuka, H., Suzuoki, Z. & Okamoto, K. Genetic predisposition to stroke in spontaneously hypertensive rats. Am. J. Physiol. 230, 1354-1359 (1976).
21. Volpe, M. et al. Relation of plasma renin to end organ damage and to protection of K+ feeding in stroke-prone hypertensive rats. Hypertension 15, 318-326 (1990).
22. Yamori, Y., Horie, R., Akiguchi, I., Kihara, M., Nara, Y. & Lovenberg, W. Symptomatological classification in the development of stroke in stroke-prone spontaneously hypertensive rats. Jap. Circ. J. 46, 274-283 (1982).
23. Sadoshima, S., Busija, D.W. & Heistad, D.D. Mechanisms of protection against stroke in stroke-prone spontaneously hypertensive rats. Am. J. Physiol. 244, H406-H412 (1983).
24. Tagami, M. et al. Permeability of intracranial extracerebral vessels in stroke-prone SHR. Stroke 12, 862-857 (1981).
25. Tagami, M. et al. Ultrastructural characteristics of occluded perforating arteries in stroke-prone spontaneously hypertensive rats. Stroke 18, 733-740 (1987).
26. Kreutz, R. et al. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc. Natl. Acad. Sci. USA 92, 8778-8782 (1995).
27. Hilbert, P. et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353, 521-529 (1991).
28. Jacob, H.E. et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67, 213-224 (1991).
29. Hubner, N., Kreutz, R., Takahashi, S., Ganten, D. & Lindpaintner, K. Unlike human hypertension, blood pressure in a heredetary hypertensive rat strain shows no linkage to the angiotensinogen locus. Hypertension 23, 797-801 (1994).
30. Lander, E.S. & Kruglyak, L. Genetic dissection of complex traits: Guidelines for interpreting linkage results. Nature Genet. 11, 241-247 (1995).
31. Witte, J.S., Elston, R.C.; Curtis D. Genetic dissection of complex traits (correspondence). Nature Genet. 12, 355-357 (1996).
32. Lathrop, G.M. & Lalouel, J.M. Easy calculations of lod scores and genetic risks on small computers. Am. J. Hum. Genet. 36, 460-465 (1984).
33. Jacob, H. et al. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nature Genet. 9, 63-69 (1995).
34. Needleman, P. et al. The biochemical pharmacology of atrial peptides. Annu. Rev. Pharmacol. Toxicol. 29, 23-54 (1989).
35. Yamori, Y. et al. Pathogenetic similarity of strokes in stroke-prone, spontaneously hypertensive rats and humans. Stroke 7, 46-53 (1976).
36. Yamori, Y. et al. Dietary risk factors of stroke and hypertension in Japan - Part 1: Methodological assessment of urinalysis for dietary salt and protein intakes. Jap. Circ. J. 46, 933-938 (1982).
37. Volpe, A. et al. Association and cosegregatio nof stroke with impaired endothelium-dependent vasorelaxation in stroke-prone, spontaneously hypertensive rats. J. Clin. Invest. (in the press).
38. Ducros, A. et al. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, genetic homogeneity, and mapping of the locus within a 2-cM interval. Am. J. Hum. Genet. 58, 171-181 (1996).
39. Lander, E.S. & Green, P. Construction of multilocus genetic maps in humans. Proc. Natl. Acad. Sci. USA 84, 2363-2367 (1987).