Left ventricular electromechanical mapping to assess efficacy of phVEGF165 gene transfer for therapeutic angiogenesis in chronic myocardial ischemia

Circulation

Volumn 102, Issue 9, 2000, Pages 965-974

  Vale, Peter R ^a   Losordo, Douglas W ^a,b   Milliken, Charles E ^a   Maysky, Michael ^a   Esakof, Darryl D ^a   Symes, James F ^a   Isner, Jeffrey M ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST ELIZABETH'S MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Ischemia; Mapping; Oronary disease

Indexed keywords

VASCULOTROPIN;

ADULT; ANGIOGENESIS; APPARATUS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; GENE EXPRESSION; GENE THERAPY; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HUMAN; IMAGE ANALYSIS; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0034730094     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.9.965     Document Type: Article

References (27)

1. Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation following vascular injury
2. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo
3. VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts
4. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart
5. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial anglogenesis
6. 165
7. 165 following intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia
8. Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results
9. Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease
10. 165 as sole therapy for myocardial ischemia
11. Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expression VEGF121 cDNA to individuals with clinically significant severe coronary artery disease
12. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: Results of a phase 1 randomized, double-blind, placebo-controlled trial
13. Electromechanical characterization of chronic myocardial infarction in the canine coronary occlusion model
14. Comparison between left ventricular electromechanical mapping and radionuclide perfusion imaging for detection of myocardial viability
15. Catheter-based myocardial gene transfer utilizing nonfluoroscopic electmmechanical left ventricular mapping
16. Preliminary animal and clinical experiences using an electromechanical endocardial mapping procedure to distinguish infarcted from healthy myocardium
17. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99 m sestamibi myocardial perfusion single-photon emission computed tomography
18. Vascular endothelial growth factor is a secreted anglogenic mitogen
19. Intraoperative multiplane transesophageal echocardiography for guiding direct myocardial gene transfer of vascular endothelial growth factor in patients with refractory angina pectoris
20. A novel method for nonfluoroscopic catheter-based electroanatomical mapping of the heart: In vitro and in vivo accuracy results
21. Left ventricular electromechanical mapping: Current understanding and diagnostic potential
22. Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs: Hibernation versus stunning?
23. Hibernating myocardium
24. Current diagnostic techniques of assessing myocardial viability in patients with hibernating and stunned myocardium
25. Catheter-based gene transfer of VEGF utilizing electromechanical LV mapping accomplishes therapeutic angiogenesis: Pre-clinical studies in swine
26. Percutaneous myocardial gene transfer of phVEGF-2
27. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion